eplerenone

steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure

Wikidata entity: Q423804

C₂₄H₃₀O₆ (P274)


Wikimedia Commons category is Eplerenone

Quantities

P4250defined daily dose50
P2067mass414.204239

P3780 active ingredient in ... Q47521716 (Inspra) Inspra
P233 canonical SMILES String CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC ???
P373 Commons category String Eplerenone ???
P366 has use ... Q12140 (medication) medication
P31 instance of ... Q113145171 (type of chemical entity) type of chemical entity
P2017 isomeric SMILES String C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC ???
P2017 isomeric SMILES String COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]34O[C@@H]3C[C@@]5(C)[C@@H](CC[C@@]56CCC(=O)O6)[C@H]14 ???
P3493 legal status (medicine) ... Q879952 (boxed warning) boxed warning
P8026 LiverTox likelihood score ... Q83284878 (Լյարդի ախտահարման հավանականության E կատեգորիա) Լյարդի ախտահարման հավանականության E կատեգորիա
P2175 medical condition treated ... Q41861 (arterial hypertension) arterial hypertension
P1748 NCI Thesaurus ID String C47513 ???
P3489 pregnancy category ... Q3679234 (Australian pregnancy category B3) Australian pregnancy category B3
P3489 pregnancy category ... Q28123616 (US pregnancy category B) US pregnancy category B
P769 significant drug interaction ... Q45050 (tenoxicam) tenoxicam
P769 significant drug interaction ... Q155472 (valsartan) valsartan
P769 significant drug interaction ... Q186969 (ibuprofen) ibuprofen
P769 significant drug interaction ... Q221520 (triamterene) triamterene
P769 significant drug interaction ... Q244408 (Diclofenac) Diclofenac
P769 significant drug interaction ... Q408801 (celecoxib) celecoxib
P769 significant drug interaction ... Q409192 ((RS)-ketoprofen) (RS)-ketoprofen
P769 significant drug interaction ... Q277785 (perindopril) perindopril
P769 significant drug interaction ... Q347941 (parecoxib) parecoxib
P769 significant drug interaction ... Q408676 (piroxicam) piroxicam
P769 significant drug interaction ... Q409231 (indomethacin) indomethacin
P769 significant drug interaction ... Q410074 (losartan) losartan
P769 significant drug interaction ... Q411229 (itraconazole) itraconazole
P769 significant drug interaction ... Q412666 (ramipril) ramipril
P769 significant drug interaction ... Q414028 (meloxicam) meloxicam
P769 significant drug interaction ... Q415970 (candesartan) candesartan
P769 significant drug interaction ... Q419890 ((±)-flurbiprofen) (±)-flurbiprofen
P769 significant drug interaction ... Q419995 (amiloride) amiloride
P769 significant drug interaction ... Q421119 (captopril) captopril
P769 significant drug interaction ... Q422185 (enalapril) enalapril
P769 significant drug interaction ... Q422188 (spironolactone) spironolactone
P769 significant drug interaction ... Q422665 (trimethoprim) trimethoprim
P769 significant drug interaction ... Q425207 (nabumetone) nabumetone
P769 significant drug interaction ... Q425293 (fosinopril) fosinopril
P769 significant drug interaction ... Q481757 (aceclofenac) aceclofenac
P769 significant drug interaction ... Q2465218 ((RS)-etodolac) (RS)-etodolac
P769 significant drug interaction ... Q2555245 ((RS)-fenoprofen) (RS)-fenoprofen
P769 significant drug interaction ... Q596022 (quinapril) quinapril
P769 significant drug interaction ... Q733186 (telmisartan) telmisartan
P769 significant drug interaction ... Q929420 (trandolapril) trandolapril
P769 significant drug interaction ... Q47495698 (lisinopril dihydrate) lisinopril dihydrate
P769 significant drug interaction ... Q947266 (irbesartan) irbesartan
P769 significant drug interaction ... Q963093 (sulindac) sulindac
P769 significant drug interaction ... Q1215575 (naproxen) naproxen
P279 subclass of ... Q27163505 (LSM-1524) LSM-1524
P2868 subject has role ... Q3290587 (antimineralocorticoid) antimineralocorticoid
External Ids
P267ATC codeC03DA04
P231CAS Registry Number107724-20-9
P683ChEBI ID31547
P592ChEMBL IDCHEMBL1095097
P661ChemSpider ID132492
P715DrugBank IDDB00700
P11198DrugCentral ID1032
P8494DSSTOX compound identifierDTXCID0026094
P3117DSSTox substance IDDTXSID2046094
P232EC number600-850-8
P2566ECHA Substance Infocard ID100.106.615
P646Freebase ID/m/0bd3st
P595Guide to Pharmacology Ligand ID2876
P2062HSDB ID7522
P2057Human Metabolome Database IDHMDB0014838
P234InChIInChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
P235InChIKeyJUKPWJGBANNWMW-VWBFHTRKSA-N
P665KEGG IDD01115
P7830LiverTox IDEplerenone
P10245MedlinePlus drug identifiera603004
P486MeSH descriptor IDD000077545
P672MeSH tree codeD02.540.383
P672MeSH tree codeD04.210.500.745.745.329
P6366Microsoft Academic ID (discontinued)2780072264
P2115NDF-RT IDN0000148782
P10283OpenAlex IDC2780072264
P4235PatientsLikeMe treatment IDeplerenone
P3636PDB ligand IDYNU
P11199Probes And Drugs IDPD009838
P662PubChem CID443872
P3345RxNorm CUI298869
P2877SureChEMBL ID21515
P2892UMLS CUIC0961485
P11089UniChem compound ID543755
P652UNII6995V82D0B
P11143WikiProjectMed IDEplerenone

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