Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

scientific article published on 13 November 2012

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1261/RNA.034769.112
P932PMC publication ID3527724
P698PubMed publication ID23150874
P5875ResearchGate publication ID233412439

P2093author name stringKumiko Ui-Tei
Kenji Nishi
Tatsuya Nagasawa
Ai Nishi
P2860cites workTranslation repression in human cells by microRNA-induced gene silencing requires RCK/p54Q21146051
Identification of novel argonaute-associated proteinsQ24295156
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAsQ24299641
Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding proteinQ24300961
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsQ24302072
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingQ24306517
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencingQ24310166
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationQ24310618
Ribonuclease activity and RNA binding of recombinant human DicerQ24315047
The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasmQ24315066
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteinsQ24318187
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAsQ24321397
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free systemQ24328771
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic specklesQ24515264
Real-time quantification of microRNAs by stem-loop RT-PCRQ24535510
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodiesQ24540223
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAsQ24540256
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesQ24554481
Argonaute HITS-CLIP decodes microRNA-mRNA interaction mapsQ24645826
A role for the P-body component GW182 in microRNA functionQ24669847
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionQ24685870
The nuclear pore complexQ71778522
Immunohistochemical analysis of RNA-induced silencing complex-related proteins AGO2 and TNRC6A in prostate and esophageal cancersQ84076487
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylationQ27659139
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Nuclear export of microRNA precursorsQ27860686
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domainQ28250307
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cellsQ28260424
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnoverQ28281490
Disruption of GW bodies impairs mammalian RNA interferenceQ28281500
siRNAs can function as miRNAsQ29615070
siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effectQ30931909
Leucine-rich nuclear-export signals: born to be weakQ31151910
Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailersQ33586217
Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation stepsQ34064080
Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles.Q34256108
Classical nuclear localization signals: definition, function, and interaction with importin alphaQ34591163
Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cellsQ34653770
Nuclear and cytoplasmic localization of neural stem cell microRNAsQ34706687
Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promotersQ35120827
Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencingQ35137801
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMDQ35740527
Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.Q36344405
GW182 family proteins are crucial for microRNA-mediated gene silencingQ36927175
MicroRNA-directed transcriptional gene silencing in mammalian cellsQ36945167
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAsQ36990752
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interferenceQ37071304
MicroRNAs with a nucleolar locationQ37344528
Cellular microRNA and P bodies modulate host-HIV-1 interactionsQ37391014
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencingQ37522850
A multifunctional human Argonaute2-specific monoclonal antibodyQ38569214
Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans.Q39681612
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target releaseQ39792632
Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.Q39869766
Multiple independent domains of dGW182 function in miRNA-mediated repression in DrosophilaQ39869773
A hexanucleotide element directs microRNA nuclear import.Q41412805
Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.Q41887103
A C-terminal silencing domain in GW182 is essential for miRNA functionQ41908974
Cellular internalization of green fluorescent protein fused with herpes simplex virus protein VP22 via a lipid raft-mediated endocytic pathway independent of caveolae and Rho family GTPases but dependent on dynamin and Arf6.Q41942565
Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repressionQ42205780
Specific and potent RNAi in the nucleus of human cellsQ45345569
The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegansQ47068671
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
gene silencingQ1431332
P304page(s)17-35
P577publication date2012-11-13
P1433published inRNAQ7277164
P1476titleHuman TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus
P478volume19

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