Mammalian epigenetic mechanisms

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Mammalian epigenetic mechanisms is …
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P356DOI10.1002/IUB.1264
P8608Fatcat IDrelease_gcnq7mz5hbf2bkygdkcccnz3si
P3181OpenCitations bibliographic resource ID2049140
P698PubMed publication ID24706538
P5875ResearchGate publication ID261409269

P2093author name stringSriharsa Pradhan
Guoqiang Zhang
P2860cites workBiochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2Q36666196
CpG island density and its correlations with genomic features in mammalian genomesQ36739399
DNA methylation and transcriptional noiseQ36811567
Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity.Q36917479
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.Q36967574
Arginine methylation at a glanceQ37023403
DNA methylation presents distinct binding sites for human transcription factorsQ37145633
Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29aQ37157046
Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identityQ37157267
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturationQ37252738
Charting a dynamic DNA methylation landscape of the human genomeQ37292011
Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseasesQ37350872
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compactionQ37358012
DNMT1-interacting RNAs block gene-specific DNA methylationQ37408576
CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.Q37454774
Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexesQ37469434
Signals and combinatorial functions of histone modificationsQ37870190
Active DNA demethylation by Gadd45 and DNA repairQ37984958
DNA methylation dynamics during the mammalian life cycleQ38061120
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identityQ38323091
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissueQ21563356
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Translating the Histone CodeQ22065840
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2Q22337290
JMJD6 is a histone arginine demethylaseQ24298169
Reduced histone biotinylation in multiple carboxylase deficiency patients: a nuclear role for holocarboxylase synthetaseQ24299635
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brainQ24299862
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repressionQ24300386
Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNAQ24306661
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activityQ24309061
Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteinsQ24309409
YY1 tethers Xist RNA to the inactive X nucleation centerQ24311256
Repression of p53 activity by Smyd2-mediated methylationQ24315991
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Q24316558
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAsQ24321397
UHRF1 plays a role in maintaining DNA methylation in mammalian cellsQ24336152
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instabilityQ24336910
Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferasesQ24534264
The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1Q24606880
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repairQ24608279
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing lossQ24630545
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylationQ36381487
Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinomaQ36402751
MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexesQ36435178
Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylationQ36512977
Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4.Q36561147
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal developmentQ36614856
Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoterQ38346589
MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells.Q39064248
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replicationQ39098794
Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genesQ39643251
Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modificationsQ39673131
A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation.Q39707641
DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compactionQ39753654
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cellsQ40166601
A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancerQ40236523
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cellsQ40405040
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cellsQ40559173
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.Q40680118
Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.Q40753457
The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA.Q41848393
Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18Q41849919
Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleusQ42424730
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrestQ42738049
Isoform-specific phosphorylation of human linker histone H1.4 in mitosis by the kinase Aurora B.Q42811550
Appearance and heterochromatin localization of HP1α in early mouse embryos depends on cytoplasmic clock and H3S10 phosphorylation.Q42834540
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylationQ43147112
Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36.Q43158410
Learning how to read ADP-ribosylationQ43266938
Control of the hippo pathway by Set7-dependent methylation of Yap.Q46240754
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.Q48114368
Histone H1 poly[ADP]-ribosylation regulates the chromatin alterations required for learning consolidation.Q48179492
Methylation-sensitive binding of transcription factor YY1 to an insulator sequence within the paternally expressed imprinted gene, Peg3.Q48262719
Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells.Q50642550
Birth of the snoRNPs: the evolution of the modification-guide snoRNAs.Q51093637
Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.Q51983259
Epigenetic reprogramming in mouse primordial germ cellsQ57086629
Human DNA methylomes at base resolution show widespread epigenomic differencesQ24633677
MeCP2, a key contributor to neurological disease, activates and represses transcriptionQ24647533
DNA methylation and microRNA dysregulation in cancerQ26998741
Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA MethylationQ27666325
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stabilityQ27666366
Structural Basis of the Versatile DNA Recognition Ability of the Methyl-CpG Binding Domain of Methyl-CpG Binding Domain Protein 4Q27675890
High-resolution profiling of histone methylations in the human genomeQ27860906
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcriptionQ27932406
Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.Q27934188
Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityQ28131773
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulationQ28141828
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatinQ28187783
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatinQ28236172
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and developmentQ28241669
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genesQ28255974
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survivalQ28264400
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosineQ28281009
Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteinsQ28305786
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprintingQ28508038
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineQ28585429
HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 bindingQ28587228
Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylationQ28592823
Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylationQ28609169
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencingQ28854369
Single-cell Hi-C reveals cell-to-cell variability in chromosome structureQ29397049
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nucleiQ29616800
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menQ29619117
On how mammalian transcription factors recognize methylated DNA.Q30426003
DNA methylation-dependent chromatin fiber compaction in vivo and in vitro: requirement for linker histoneQ32041055
Maintenance of paternal methylation and repression of the imprinted H19 gene requires MBD3Q33294657
Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cellsQ33526045
Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphaseQ33589953
Rethinking how DNA methylation patterns are maintainedQ33763852
Histone H1 phosphorylation is associated with transcription by RNA polymerases I and IIQ33839979
CpG methylation is maintained in human cancer cells lacking DNMT1.Q33901029
Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in malesQ34021143
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4.Q34093543
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.Q34103901
Dynamic reprogramming of DNA methylation in the early mouse embryo.Q34108785
MicroRNA‐205–directed transcriptional activation of tumor suppressor genes in prostate cancerQ34133056
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosineQ34154619
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cellsQ34166536
Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1.Q34207667
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.Q34249450
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethalityQ34276391
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferasesQ34325535
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sitesQ34344734
von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity.Q34361522
MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndromeQ34420937
H3K36 methylation antagonizes PRC2-mediated H3K27 methylationQ34624209
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Q34762752
Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequencesQ34804710
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosisQ34835189
De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent stateQ34976653
Hotspots of transcription factor colocalization in the genome of Drosophila melanogasterQ35033165
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survivalQ35080450
The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.Q35098579
Active DNA demethylation mediated by DNA glycosylasesQ35108672
Male germ cells express abundant endogenous siRNAsQ35164762
Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage responseQ35182983
H3K4 tri-methylation provides an epigenetic signature of active enhancersQ35422275
DiseaseMeth: a human disease methylation databaseQ35631191
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domainsQ35788928
Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy systemQ35796875
On the presence and role of human gene-body DNA methylation.Q36050706
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesisQ36199783
CTCF-mediated functional chromatin interactome in pluripotent cellsQ36218315
Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stationsQ36285384
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsyQ36301666
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)240-56
P577publication date2014-04-01
P1433published inIUBMB LifeQ15764029
P1476titleMammalian epigenetic mechanisms
P478volume66

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