Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

scientific article published on 12 August 2008

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKN503
P932PMC publication ID2532731
P698PubMed publication ID18697815
P5875ResearchGate publication ID23165640

P50authorCarsten Müller-TidowQ23564829
P2093author name stringLisa Wiesmüller
Karl Heinz Scheidtmann
Cindy Baumann
Michael Böhringer
Anja Restle
Martin Färber
P2860cites workThe cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repairQ24338781
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteinsQ24554521
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1Q24564859
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestQ24677047
The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53Q24679341
Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53Q25256778
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Surfing the p53 networkQ28032484
RETRACTED: Small molecule-based reversible reprogramming of cellular lifespanQ28245362
The interaction of p53 with replication protein A mediates suppression of homologous recombinationQ28288360
Pathways of DNA double-strand break repair during the mammalian cell cycleQ28608969
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaksQ29614215
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsQ29614216
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisQ29614217
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DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?Q33734562
Mutant p53: gain-of-function oncoproteins and wild-type p53 inactivatorsQ33737277
Cyclin A1 expression in leukemia and normal hematopoietic cellsQ33854451
Mutant p53 and genomic instability in a transgenic mouse model of breast cancerQ33860831
Physical and functional interaction between p53 and the Werner's syndrome proteinQ33875710
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.Q33884556
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.Q33908542
Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinasesQ34298718
Human topoisomerase I cleavage complexes are repaired by a p53-stimulated recombination-like reaction in vitro.Q34397019
p53 accumulates but is functionally impaired when DNA synthesis is blockedQ34641149
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombinationQ34775325
Sensing of intermediates in V(D)J recombination by ATM.Q35005088
Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNAQ35050115
Phosphorylation of serine 18 regulates distinct p53 functions in miceQ35545143
p53's double life: transactivation-independent repression of homologous recombination.Q35774503
The p53 response to DNA damageQ35848498
p53: traffic cop at the crossroads of DNA repair and recombinationQ36028209
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.Q36239424
p53 in recombination and repairQ36423948
Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutationsQ37286062
The cyclin A1-CDK2 complex regulates DNA double-strand break repair.Q37527220
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responsesQ38351593
DNA substrate dependence of p53-mediated regulation of double-strand break repairQ39675323
Werner syndrome protein limits MYC-induced cellular senescenceQ39895677
Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms.Q39922858
p53 modulates homologous recombination by transcriptional regulation of the RAD51 geneQ40344795
Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombinationQ40439624
Modulation of p53 binding to Holliday junctions and 3-cytosine bulges by phosphorylation events.Q40458703
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosisQ40506599
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencingQ40519902
Limited role of N-terminal phosphoserine residues in the activation of transcription by p53.Q40570035
Recombination at chromosomal sequences involved in leukaemogenic rearrangements is differentially regulated by p53.Q40595959
p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombinationQ40647425
Association of p53 and MSH2 with recombinative repair complexes during S phaseQ40720210
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemiaQ40840724
Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.Q40946375
Rescue of K562 cells from MDM2-modulated p53-dependent apoptosis by growth factor-induced differentiationQ40965972
Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.Q41842385
p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repairQ42443549
Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteinsQ44010460
Phosphorylation site interdependence of human p53 post-translational modifications in response to stressQ44513266
Werner protein stimulates topoisomerase I DNA relaxation activityQ44652166
Cell cycle arrest induced in human breast cancer cells by cyclin-dependent kinase inhibitors: a comparison of the effects exerted by roscovitine and olomoucineQ45183171
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.Q46200576
The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppressionQ46843477
Wild-type and mutant forms of p53 activate human topoisomerase I: a possible mechanism for gain of function in mutants.Q48030084
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.Q52536369
Modulation of DNA Topoisomerase I Activity byp53Q57259136
p53 phosphorylation mutants retain transcription activityQ72560886
c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expressionQ73254128
Resolution of undistorted symmetric immobile DNA junctions by vaccinia topoisomerase IQ75444235
Cyclin A1 is highly expressed in aggressive testicular germ cell tumorsQ78819158
Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeatQ81554284
P433issue16
P921main subjectphosphorylationQ242736
P304page(s)5362-5375
P577publication date2008-08-12
P1433published inNucleic Acids ResearchQ135122
P1476titleDissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants
P478volume36

Reverse relations

cites work (P2860)
Q31029673ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells
Q38760793Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma
Q34158315Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs
Q35820674Cancer-testis antigen cyclin A1 is broadly expressed in ovarian cancer and is associated with prolonged time to tumor progression after platinum-based therapy
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Q44176860Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy
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Q91291958Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer
Q92153461How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor
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Q37126273p53 suppresses hyper-recombination by modulating BRCA1 function

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