Impaired Na⁺-dependent regulation of acetylcholine-activated inward-rectifier K⁺ current modulates action potential rate dependence in patients with chronic atrial fibrillation.

scientific article published on 24 March 2013

Impaired Na⁺-dependent regulation of acetylcholine-activated inward-rectifier K⁺ current modulates action potential rate dependence in patients with chronic atrial fibrillation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2013.03.011
P698PubMed publication ID23531443
P5875ResearchGate publication ID236083055

P50authorLutz PottQ58944398
Dobromir DobrevQ110902296
Jordi HeijmanQ43278527
P2093author name stringNiels Voigt
Ursula Ravens
Anne Trausch
Elisa Mintert-Jancke
P2860cites workDifferential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling.Q54562016
Na+Promotes the Dissociation between GαGDPand Gβγ, Activating G Protein-gated K+ChannelsQ58539164
Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heartQ59068860
Failure in the rate adaptation of the atrial refractory period: its relationship to vulnerabilityQ72686900
Ionic mechanisms of electrical remodeling in human atrial fibrillationQ73311823
Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillationQ73381111
G-Protein beta(3)-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currentsQ74131870
Inwardly rectifying potassium channels: their structure, function, and physiological rolesQ24296441
Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytesQ28141616
Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillationQ30476498
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillationQ34473254
Lifetime risk for development of atrial fibrillation: the Framingham Heart StudyQ34550202
Recent advances in the molecular pathophysiology of atrial fibrillation.Q35142870
Remodeling of cardiomyocyte ion channels in human atrial fibrillationQ35186203
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillationQ35528532
Intracellular Ca(2+) concentration and rate adaptation of the cardiac action potentialQ35756784
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillationQ36331025
K+ current changes account for the rate dependence of the action potential in the human atrial myocyteQ37406359
Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase.Q37416395
New antiarrhythmic drugs for treatment of atrial fibrillation.Q37718340
Novel molecular targets for atrial fibrillation therapyQ37998312
A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).Q42042690
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillationQ42459986
Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillationQ42474874
Kinetic modeling of Na(+)-induced, Gbetagamma-dependent activation of G protein-gated K(+) channelsQ42475884
Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.Q42497605
Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillationQ42509641
Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillationQ42514701
Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4.Q42519144
Effects of internal and external Na+ ions on inwardly rectifying K+ channels in guinea-pig ventricular cellsQ42622186
Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heartQ42841709
The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillationQ43782709
Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potenQ43803581
Human inward rectifier potassium channels in chronic and postoperative atrial fibrillationQ44025889
Remodeling of Ca(2+)-handling by atrial tachycardia: evidence for a role in loss of rate-adaptationQ44025893
Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate.Q46153878
Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytesQ46897896
Molecular mechanism for sodium-dependent activation of G protein-gated K+ channelsQ48564702
Potassium inhibition of sodium-activated potassium (K(Na)) channels in guinea-pig ventricular myocytes.Q52076795
Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heartQ53914000
P407language of work or nameEnglishQ1860
P921main subjectatrial fibrillationQ815819
P304page(s)142-152
P577publication date2013-03-24
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleImpaired Na⁺-dependent regulation of acetylcholine-activated inward-rectifier K⁺ current modulates action potential rate dependence in patients with chronic atrial fibrillation
P478volume61

Reverse relations

cites work (P2860)
Q38822819Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.
Q35126445Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.
Q57161239Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges
Q38638006Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.
Q39638066Effect of ethanol at clinically relevant concentrations on atrial inward rectifier potassium current sensitive to acetylcholine
Q38834737Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation
Q33166761G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.
Q26799483Methods for isolating atrial cells from large mammals and humans
Q47228722Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation
Q38648539New antiarrhythmic targets in atrial fibrillation
Q38979816Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine
Q92067940PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL -insights from human atrial modelling
Q47665926Slow [Na+]i dynamics impacts arrhythmogenesis and spiral wave reentry in cardiac myocyte ionic model
Q38585790The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results
Q91637728Understanding the Beat-to-Beat Variations of P-Waves Morphologies in AF Patients During Sinus Rhythm: A Scoping Review of the Atrial Simulation Studies

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