Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation

scientific article published on 17 September 2009

Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00210-009-0452-6
P698PubMed publication ID19760273

P50authorDobromir DobrevQ110902296
P2093author name stringKlaus Matschke
Niels Voigt
Ursula Ravens
Erich Wettwer
Torsten Christ
Anne Trausch
Nadiia Rozmaritsa
Thomasz Zimniak
P2860cites workACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial FibrillationQ22306351
Effect of dronedarone on cardiovascular events in atrial fibrillationQ28235128
Distribution of the muscarinic K+ channel proteins Kir3.1 and Kir3.4 in the ventricle, atrium, and sinoatrial node of heartQ28570285
Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillationQ30476498
Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels.Q33206302
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillationQ34473254
New ideas about atrial fibrillation 50 years on.Q34503407
Remodeling of cardiomyocyte ion channels in human atrial fibrillationQ35186203
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytesQ35870948
Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pigQ35872647
JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurementsQ36750848
Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periodsQ36801449
Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillationQ36842497
New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillationQ37106294
Inward rectifier potassium currents as a target for atrial fibrillation therapyQ37231697
Atrial remodeling and atrial fibrillation: mechanisms and implications.Q37609710
Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalenceQ40310174
Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68,798), a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia. Dofetilide Arrhythmia Study GroupQ42274536
Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillationQ42509641
The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillationQ43782709
Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potenQ43803581
Human inward rectifier potassium channels in chronic and postoperative atrial fibrillationQ44025889
Atrial effects of the novel K(+)-channel-blocker AVE0118 in anesthetized pigs.Q44653099
Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atriumQ44799799
Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacologyQ45025687
Safety of the novel atrial-selective K+-channel blocker AVE0118 in experimental heart failureQ46274903
Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytesQ46897896
Plasma and tissue levels of flecainide in ratsQ48317019
Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytesQ68339880
Plasma propafenone concentration in the evaluation of anti-arrhythmic efficacyQ70221027
Potassium channel blocking properties of propafenone in rabbit atrial myocytesQ70602374
Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytesQ71665817
Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsQ73298210
Ionic mechanisms of electrical remodeling in human atrial fibrillationQ73311823
Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillationQ73381111
G-Protein beta(3)-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currentsQ74131870
Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goatQ80233954
Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmiasQ83058608
P433issue3
P921main subjectatrial fibrillationQ815819
P304page(s)251-259
P577publication date2009-09-17
P1433published inNaunyn-Schmiedeberg's Archives of PharmacologyQ1468251
P1476titleInhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation
P478volume381

Reverse relations

cites work (P2860)
Q38111636Atrial selectivity of antiarrhythmic drugs
Q37809985Atrial-selective drugs for treatment of atrial fibrillation
Q84032438Atrial-selective sodium channel block by dronedarone: sufficient to terminate atrial fibrillation?
Q27027326Calcium dysregulation in atrial fibrillation: the role of CaMKII
Q47254019Comparison of the effects of IK,ACh, IKr, and INa block in conscious dogs with atrial fibrillation and on action potentials in remodeled atrial trabeculae.
Q42436292Impaired Na⁺-dependent regulation of acetylcholine-activated inward-rectifier K⁺ current modulates action potential rate dependence in patients with chronic atrial fibrillation.
Q37063856Isolation of human atrial myocytes for simultaneous measurements of Ca2+ transients and membrane currents
Q26799483Methods for isolating atrial cells from large mammals and humans
Q47228722Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation
Q24292961NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy
Q38069201New directions in antiarrhythmic drug therapy for atrial fibrillation
Q48644420Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels.
Q37998312Novel molecular targets for atrial fibrillation therapy
Q43191375Novel pharmacological approaches for antiarrhythmic therapy
Q37106753Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation
Q38103541Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update
Q47433213Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule
Q36900723The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers
Q37821928The pharmaceutical pipeline for atrial fibrillation
Q37799958The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications
Q47748973Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance
Q50690847[New developments in the antiarrhythmic therapy of atrial fibrillation].

Search more.