Novel pharmacological approaches for antiarrhythmic therapy

scientific article published on 15 January 2010

Novel pharmacological approaches for antiarrhythmic therapy is …
instance of (P31):
editorialQ871232
scholarly articleQ13442814

External links are
P356DOI10.1007/S00210-009-0487-8
P698PubMed publication ID20082192

P2093author name stringUrsula Ravens
P2860cites workRegulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genisteinQ24642787
Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillationQ28118782
Potassium leak channels and the KCNK family of two-P-domain subunitsQ28205333
Cardiac excitation-contraction couplingQ28216347
Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillationQ28245803
Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current densityQ28284487
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression TrialQ28300531
Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillationQ30476498
Cardiac adrenergic control and atrial fibrillationQ33792556
Ventricular fibrillation: mechanisms of initiation and maintenanceQ33938669
Biological pacemaker created by gene transferQ34149202
A comparison of rate control and rhythm control in patients with atrial fibrillationQ34162727
Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse heartsQ34247000
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillationQ34473254
New ideas about atrial fibrillation 50 years on.Q34503407
hERG potassium channels and cardiac arrhythmiaQ34504394
DronedaroneQ34610881
Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium currentQ34693729
Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goatsQ34721297
Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppressionQ34997952
Remodeling of cardiomyocyte ion channels in human atrial fibrillationQ35186203
Electrophysiological changes in heart failure and their relationship to arrhythmogenesisQ35635094
Nonchannel drug targets in atrial fibrillationQ35729433
Activators of cation channels: potential in treatment of channelopathiesQ35988564
Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sitesQ36082827
Epidemiological profile of atrial fibrillation: a contemporary perspectiveQ36272311
Calcium-activated potassium channels and the regulation of vascular toneQ36380601
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.Q36427756
Calcium-activated nonselective cation channels in mammalian cardiomyocytesQ36596071
Cardiac fibrillation: from ion channels to rotors in the human heartQ36793599
Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillationQ36842497
Anti-arrhythmic drug therapy for atrial fibrillation: current anti-arrhythmic drugs, investigational agents, and innovative approachesQ37178627
Roles of TRP channels in the development of cardiac hypertrophyQ37207026
Role of potassium currents in cardiac arrhythmiasQ37226299
New drugs targeting the cardiac ultra-rapid delayed-rectifier current (I Kur): rationale, pharmacology and evidence for potential therapeutic valueQ37231704
Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics.Q37268790
The pathological role of transient receptor potential channels in heart diseaseQ37388339
Transient receptor potential: a large family of new channels of which several are involved in cardiac arrhythmiaQ37398665
Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillationQ37584282
Atrial remodeling and atrial fibrillation: mechanisms and implications.Q37609710
Primary and secondary prevention of atrial fibrillation with statins and polyunsaturated fatty acids: review of evidence and clinical relevanceQ37638445
Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptidesQ37639916
The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43.Q38756624
Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivoQ39792452
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillationQ42459986
Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillationQ42509641
Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazineQ43196284
Vernakalant hydrochloride for the treatment of atrial fibrillationQ43235607
Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug targetQ43270475
The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone.Q43272225
Late sodium current is a novel target for amiodarone: studies in failing human myocardiumQ43601320
Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membraneQ44201844
Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytesQ44879643
Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.Q45284438
The anti-arrhythmic peptide AAP10 remodels Cx43 and Cx40 expression and functionQ46072269
Defective cardiac ryanodine receptor regulation during atrial fibrillationQ46455370
Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channelsQ46477997
Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findingsQ46522726
Is there any hope for angiotensin-converting enzyme inhibitors in atrial fibrillation?Q47572890
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.Q48797106
Signal-averaged P wave: predictor of atrial fibrillationQ49088971
Do we need new antiarrhythmic compounds in the era of implantable cardiac devices and percutaneous ablation?Q51328980
Calcium-activated potassium current: a novel ion channel candidate in atrial fibrillation.Q51742032
Sudden cardiac death in heart failure. The role of abnormal repolarizationQ72791800
Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsQ73298210
Differing sympathetic and vagal effects on atrial fibrillation in dogs: role of refractoriness heterogeneityQ73645093
Tarantula peptide inhibits atrial fibrillationQ73851329
Structural changes of atrial myocardium due to sustained atrial fibrillation in the goatQ73914865
Autonomic tone variations before the onset of paroxysmal atrial fibrillationQ74268938
Characterization of a [Ca2+]i-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+Q77746025
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sortQ77960625
Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogsQ79562278
Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmiasQ83058608
[Autonomously promoted extension effect in Purkinje fibers, papillary muscles and trabeculae carneae of rhesus monkeys]Q93766447
P433issue3
P304page(s)187-193
P577publication date2010-01-15
P1433published inNaunyn-Schmiedeberg's Archives of PharmacologyQ1468251
P1476titleNovel pharmacological approaches for antiarrhythmic therapy
P478volume381

Reverse relations

cites work (P2860)
Q35089887Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels
Q37847174Emerging antiarrhythmic agents: a personal view from the Far East
Q42160738In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics
Q34953291Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation
Q48644420Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels.
Q45872055Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study
Q34772923The pathology and treatment of cardiac arrhythmias: focus on atrial fibrillation

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