Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation

scientific article published on 31 March 2009

Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-08-4867
P932PMC publication ID2669835
P698PubMed publication ID19336568
P5875ResearchGate publication ID24248427

P2093author name stringGregory S Thomas
Hasem Habelhah
Ken Blackwell
Laiqun Zhang
P2860cites workPKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathwaysQ36328818
Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cellsQ38308121
Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.Q39318861
NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell deathQ39804728
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosisQ39921849
Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinaseQ40266943
Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cellsQ40733134
Activation of IkappaB kinase beta by protein kinase C isoformsQ24554525
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulatorsQ28198125
Tumor necrosis factor receptor-associated factors (TRAFs)Q28199382
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathwayQ28202626
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell deathQ28209948
Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa BQ28578089
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerQ29614599
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
Ubiquitin signalling in the NF-kappaB pathwayQ29616322
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient miceQ29618716
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signalingQ33267561
Protein kinase C binding partnersQ33843447
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progressionQ33891330
Adaptor proteins in protein kinase C-mediated signal transductionQ34095764
NF-kappaB as a therapeutic target in cancerQ34750172
NF-kappaB activation by protein kinase C isoforms and B-cell functionQ35043854
Emerging and diverse roles of protein kinase C in immune cell signallingQ35564874
Nuclear factor-kappaB: the enemy withinQ35893620
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
cell deathQ2383867
P304page(s)3665-3672
P577publication date2009-03-31
P1433published inCancer ResearchQ326097
P1476titlePhosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation
P478volume69

Reverse relations

cites work (P2860)
Q35563028Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis
Q29617418Crosstalk in NF-κB signaling pathways
Q42283261DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion
Q41280310Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer
Q36397332IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation
Q38365120Molecular targets of luteolin in cancer
Q41335368PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury
Q35995213Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.
Q34765284Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.
Q36562365Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.
Q36479735TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.
Q37299479TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification
Q36972287TRAF molecules in cell signaling and in human diseases
Q89636329TRAF2 Ser-11 phosphorylation promotes cytosolic translocation of the CD40 complex to regulate downstream signaling pathways
Q33794121TRAF2 is an NF-κB-activating oncogene in epithelial cancers.
Q34470973TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death

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