Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.

scientific article

Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003409
P932PMC publication ID3675035
P698PubMed publication ID23754945
P5875ResearchGate publication ID237098356

P50authorHiroyasu NakanoQ55277402
P2093author name stringChihiro Sasakawa
Hiroshi Ashida
P2860cites workThe pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction.Q52583128
Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectorsQ79532962
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A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory responseQ22001534
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The inflammasomesQ24304087
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Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxinQ24336442
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligasesQ24642649
Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligasesQ24647624
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activationQ24652200
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitinationQ24652618
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligasesQ27652850
Structure of a Shigella effector reveals a new class of ubiquitin ligasesQ27652851
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory responseQ27677993
Pattern recognition receptors and inflammationQ27861115
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell deathQ28209948
The versatility of Shigella effectorsQ28259971
Modulation of NF-κB signalling by microbial pathogensQ28709497
Shared principles in NF-kappaB signalingQ29547234
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryQ29615618
The inflammasome NLRs in immunity, inflammation, and associated diseasesQ29616025
Crosstalk in NF-κB signaling pathwaysQ29617418
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
Sterile inflammation: sensing and reacting to damageQ29620014
A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial AutophagyQ30540202
Subcellular targeting of Salmonella virulence proteins by host-mediated S-palmitoylationQ30620322
Sequence and molecular characterization of a multicopy invasion plasmid antigen gene, ipaH, of Shigella flexneriQ33253819
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signalingQ33267561
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.Q33582255
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymesQ34048081
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell deathQ34470973
A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression.Q35106240
NF-κB signaling pathways regulated by CARMA family of scaffold proteinsQ35347919
Molecular cloning of invasion plasmid antigen (ipa) genes from Shigella flexneri: analysis of ipa gene products and genetic mappingQ36238161
Multifunctional roles for MALT1 in T-cell activation.Q37198925
Common themes in the design and function of bacterial effectorsQ37312444
Shigella type III secretion effectors: how, where, when, for what purposes?Q37373930
Ubiquitylation in innate and adaptive immunity.Q37424798
PKC and the control of localized signal dynamics.Q37679691
Shigella deploy multiple countermeasures against host innate immune responses.Q37799075
Shigella are versatile mucosal pathogens that circumvent the host innate immune system.Q37901683
Bacteria and host interactions in the gut epithelial barrierQ37968876
Tips and tricks about Shigella invasion of epithelial cellsQ38073983
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosisQ39921849
Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C.Q39988407
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysinQ40161818
Use of Shigella flexneri ipaC and ipaH gene sequences for the general identification of Shigella spp. and enteroinvasive Escherichia coliQ40197626
High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasinQ41452257
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activationQ42451661
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneriQ42638971
rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cellsQ42947720
Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responsesQ44053369
Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleusQ46202980
Sequence variation in two ipaH genes of Shigella flexneri 5 and homology to the LRG-like family of proteinsQ48207710
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense programQ50026118
Type III secretion effectors of the IpaH family are E3 ubiquitin ligasesQ50066742
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectNF-κBQ411114
P304page(s)e1003409
P577publication date2013-06-06
P1433published inPLOS PathogensQ283209
P1476titleShigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells
P478volume9

Reverse relations

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Q91614231Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection

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