Modification of the host ubiquitome by bacterial enzymes

scientific article published on 11 February 2020

Modification of the host ubiquitome by bacterial enzymes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.MICRES.2020.126429
P932PMC publication ID7369425
P698PubMed publication ID32109687

P2093author name stringMariola J Edelmann
Julie A Maupin-Furlow
Jennifer Berglund
Ellen Verney
Rafaela Gjondrekaj
P2860cites workNleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligasesQ21131552
Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoaQ21131567
The F-box protein family.Q21194893
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory responseQ22001534
The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3Q24304497
The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunityQ24317043
Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxinQ24336442
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligasesQ24642649
Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligasesQ24647624
Ubiquitin modificationsQ26751380
Bacteria-host relationship: ubiquitin ligases as weapons of invasionQ26766507
Prokaryotic ubiquitin-like protein modificationQ26998484
Pupylation as a signal for proteasomal degradation in bacteriaQ27001018
Live cell imaging reveals novel functions of Salmonella enterica SPI2-T3SS effector proteins in remodeling of the host cell endosomal systemQ27319876
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligaseQ27649240
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligasesQ27652850
Structure of a Shigella effector reveals a new class of ubiquitin ligasesQ27652851
Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7Q27665390
Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactionsQ27677106
Assembly, analysis and architecture of atypical ubiquitin chainsQ27677234
Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin LigaseQ27680640
Legionella pneumophilaSubversion of Host Vesicular Transport by SidC Effector ProteinsQ27681557
The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling.Q27684624
Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?Q28069021
Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligaseQ28118367
The ubiquitin codeQ28265104
ChlaDub1 of Chlamydia trachomatis suppresses NF-kappaB activation and inhibits IkappaBalpha ubiquitination and degradationQ28484738
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infectionQ28484743
Ubiquitination independent of E1 and E2 enzymes by bacterial effectorsQ28485635
Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitinationQ28485638
Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functionsQ28485639
Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosisQ28486486
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosisQ28487196
Prokaryotic ubiquitin-like protein pup is intrinsically disorderedQ28487221
The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligaseQ28490017
AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plantsQ28492426
Plant pattern-recognition receptor FLS2 is directed for degradation by the bacterial ubiquitin ligase AvrPtoBQ28492434
Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial PhagosomeQ28548314
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionQ28593668
The ubiquitin system for protein degradationQ29614385
Physiological functions of thioredoxin and thioredoxin reductaseQ29615600
Reactive oxygen species, antioxidants, and the mammalian thioredoxin systemQ29619367
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector.Q33769572
Deubiquitinating enzymes as promising drug targets for infectious diseasesQ33836097
The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formationQ33889316
ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagyQ33998133
Proteomic analysis of the Burkholderia pseudomallei type II secretome reveals hydrolytic enzymes, novel proteins, and the deubiquitinase TssMQ34059012
E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substratesQ34119372
The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregatesQ34311564
Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.Q34407723
Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1.Q34452782
A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligaseQ34479090
Pseudogenization of sopA and sopE2 is functionally linked and contributes to virulence of Salmonella enterica serovar TyphiQ40158655
Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and TransmissionQ40355774
Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.Q40373215
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.Q40520196
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.Q40705607
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.Q40840610
The Salmonella effector SteA binds phosphatidylinositol 4-phosphate for subcellular targeting within host cells.Q40868296
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicidaQ41429405
The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulationQ41432802
Gene expression patterns of epithelial cells modulated by pathogenicity factors of Yersinia enterocoliticaQ41464326
GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8.Q42379443
The DUB-ious lack of ALIS in Salmonella infection: a Salmonella deubiquitinase regulates the autophagy of protein aggregatesQ42613208
A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunityQ43072304
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB.Q43300270
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway BlockadeQ44884016
Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based MotilityQ46242682
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defenceQ47396547
Host inhibition of a bacterial virulence effector triggers immunity to infectionQ47857912
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferationQ48178189
Sequence variation in two ipaH genes of Shigella flexneri 5 and homology to the LRG-like family of proteinsQ48207710
Hijacking of the Host Ubiquitin Network by Legionella pneumophilaQ49295322
A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication.Q49628029
Type III secretion effectors of the IpaH family are E3 ubiquitin ligasesQ50066742
RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases.Q50133283
Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.Q51289549
LotA, a Legionella deubiquitinase, has dual catalytic activity and contributes to intracellular growth.Q52726386
Purification and characterization of legionella U-box-type E3 ubiquitin ligase.Q54323549
Functional diversification of the NleG effector family in enterohemorrhagicQ57050148
Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatisQ57175210
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentationQ57979944
The Bacterial Proteasome at the Core of Diverse Degradation PathwaysQ64063273
Prediction of bacterial E3 ubiquitin ligase effectors using reduced amino acid peptide fingerprinting.Q64940791
Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugationQ70098539
Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectorsQ79532962
The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuoleQ81730696
Structural Insights into Non-canonical Ubiquitination Catalyzed by SidEQ88582168
Cellular functions and molecular mechanisms of non-lysine ubiquitinationQ90145443
Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain-containing Legionella effectorsQ91129714
The SseL protein inhibits the intracellular NF-κB pathway to enhance the virulence of Salmonella Pullorum in a chicken modelQ91291620
Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupBQ91301969
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylationQ92079576
Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.Q92877180
YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase ActivityQ38991950
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagyQ38999747
Bacterial E3 ligase effectors exploit host ubiquitin systemsQ39026001
Complete and ubiquitinated proteome of the Legionella-containing vacuole within human macrophagesQ39103317
Ubiquitin Ligases: Structure, Function, and Regulation.Q39219103
Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-κB p65 proteinQ39256315
Mechanisms of Deubiquitinase Specificity and Regulation.Q39302629
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.Q39722305
Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM.Q39723299
Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK.Q40115511
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradationQ40142277
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylationQ34530978
Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector FamilyQ34540701
Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signalingQ34583187
Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.Q34765284
Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein.Q34990851
Spatiotemporal regulation of a Legionella pneumophila T4SS substrate by the metaeffector SidJQ35182635
Hell's BELs: bacterial E3 ligases that exploit the eukaryotic ubiquitin machineryQ35224575
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.Q35645616
The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid dropletsQ35671636
SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system.Q35689269
ElaD, a Deubiquitinating protease expressed by E. coliQ35741864
Pseudomonas syringae pv. tomato DC3000 Type III Secretion Effector Polymutants Reveal an Interplay between HopAD1 and AvrPtoB.Q35754410
Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitinationQ35963199
The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family MembersQ35983580
Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.Q35991133
Posttranslational modification of cellular proteins by a ubiquitin-like protein in bacteria.Q36006888
Identification of Salmonella Typhimurium Deubiquitinase SseL Substrates by Immunoaffinity Enrichment and Quantitative Proteomic Analysis.Q36030951
Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophilaQ36227070
Host Cell-catalyzed S-Palmitoylation Mediates Golgi Targeting of the Legionella Ubiquitin Ligase GobX.Q36283418
Exploiting the ubiquitin and phosphoinositide pathways by the Legionella pneumophila effector, SidCQ36495024
Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophagesQ37145057
Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligationQ37229647
--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.Q37415204
Advances and pitfalls of protein structural alignmentQ37501173
Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense.Q37725770
The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector ProteasesQ37835973
Diversity of bacterial manipulation of the host ubiquitin pathwaysQ37843222
The chlamydial OTU domain-containing protein ChlaOTU is an early type III secretion effector targeting ubiquitin and NDP52.Q37846201
Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infectionQ37847236
Linear ubiquitination: a newly discovered regulator of cell signallingQ38075345
Regulation of proteolysis by human deubiquitinating enzymesQ38120938
Ubiquitination as an efficient molecular strategy employed in salmonella infectionQ38287957
A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitinationQ38684709
Bacterial E3 Ubiquitin Ligase IpaH4.5 of Shigella flexneri Targets TBK1 To Dampen the Host Antibacterial ResponseQ38809321
P304page(s)126429
P577publication date2020-02-11
P1433published inMicrobiological ResearchQ19361570
P1476titleModification of the host ubiquitome by bacterial enzymes
P478volume235

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