Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain

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Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain is …
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scholarly articleQ13442814

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P356DOI10.1007/S00429-014-0946-Y
P8608Fatcat IDrelease_p3jgnzam6baipjpqd5pmjlsp6e
P698PubMed publication ID25431268
P5875ResearchGate publication ID268876887

P50authorThomas KilduffQ16730839
Thomas C NeylanQ96306595
Deepti R WarrierQ125318896
P2093author name stringMichael D Schwartz
Alexander T Nguyen
Jacqueline Vazquez-DeRose
Thomas K Mathew
Srishti Gulati
P2860cites workOrexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorQ24315738
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityQ24317782
Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor aloneQ27300998
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 geneQ28142783
The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomniaQ28272266
The energy hypothesis of sleep revisitedQ28383752
Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro studyQ28484972
Stimulation of cortical acetylcholine release by orexin AQ28567181
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulationQ29615680
Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2.Q30311232
Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycleQ30492253
Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleusQ30984327
Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats.Q33220272
Dynamic changes in GABAA receptors on basal forebrain cholinergic neurons following sleep deprivation and recoveryQ33275036
Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neuronsQ33619265
Adenosine in sleep and wakefulnessQ33645408
Reduced number of hypocretin neurons in human narcolepsyQ33923479
Discharge patterns of neurons in cholinergic regions of the basal forebrain during waking and sleepQ34041833
Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state.Q34041843
Reassessment of the structural basis of the ascending arousal system.Q34161566
Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wakeQ34287174
Adenosine and sleep-wake regulationQ34550187
The time course of adenosine, nitric oxide (NO) and inducible NO synthase changes in the brain with sleep loss and their role in the non-rapid eye movement sleep homeostatic cascadeQ34588449
Promotion of sleep by targeting the orexin system in rats, dogs and humansQ34607196
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonistQ34628298
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy thresholdQ34975026
Integrated brain circuits: astrocytic networks modulate neuronal activity and behaviorQ35052007
Sleep-wake mechanisms and basal forebrain circuitryQ35212793
Adenosine inhibits glutamatergic input to basal forebrain cholinergic neuronsQ35994886
GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleepQ36238080
Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulnessQ36690694
Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousalQ36729270
The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesionsQ36917393
Adenosine inhibits the excitatory synaptic inputs to Basal forebrain cholinergic, GABAergic, and parvalbumin neurons in miceQ36941942
Microdialysis of GABA and glutamate: analysis, interpretation and comparison with microsensors.Q36972743
Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving ratsQ37200112
The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in ratsQ37535058
Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in ratsQ37566598
Activation of the basal forebrain by the orexin/hypocretin neurones.Q37590372
Role of zolpidem in the management of insomniaQ37765629
Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousalQ37874775
Astrocyte-neuron communication: functional consequencesQ38016361
Enhancement of acetylcholine release during REM sleep in the caudomedial medulla as measured by in vivo microdialysisQ41108760
Brain microdialysis of GABA and glutamate: what does it signify?Q41610607
Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysisQ41709009
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep lossQ41776277
Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrainQ41947724
Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviourQ42434891
Cortical projections arising from the basal forebrain: a study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferaseQ42458998
Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptorQ42464077
Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structuresQ42470987
Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitroQ42492222
Adenosine and sleep homeostasis in the Basal forebrain.Q42499140
Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of actionQ42512060
Orexins/hypocretins excite basal forebrain cholinergic neuronesQ42513781
Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleepQ42514206
Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in ratsQ42523450
Effects of lateral preoptic area application of orexin-A on sleep-wakefulnessQ43830853
Muscarinic and GABAA receptors modulate acetylcholine release in feline basal forebrainQ44287819
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.Q46052798
Involvement of adenosine A2A receptor in sleep promotionQ47755458
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognitionQ48020552
Acetylcholine and glutamate release during sleep-wakefulness in the pedunculopontine tegmental nucleus and norepinephrine changes regulated by nitric oxideQ48129453
Orexin-A facilitates emergence from propofol anesthesia in the rat.Q48146396
Effects of hypocretin-1 in 192-IgG-saporin-lesioned ratsQ48386927
Differential expression of orexin receptors 1 and 2 in the rat brainQ48693654
GABA release in the locus coeruleus as a function of sleep/wake stateQ48702520
Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving catsQ48824675
Acetylcholine liberation from cerebral cortex during paradoxical (REM) sleepQ48824810
P433issue2
P304page(s)923-940
P577publication date2014-11-28
P1433published inBrain Structure and FunctionQ13444883
P1476titleHypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain
P478volume221

Reverse relations

cites work (P2860)
Q47735977Benzodiazepines alter nucleotide and nucleoside hydrolysis in zebrafish (Danio rerio) brain
Q49989804Bmal1 knockdown suppresses wake and increases immobility without altering orexin A, corticotrophin-releasing hormone, or glutamate decarboxylase.
Q37107841Effect of two GABA-ergic drugs on the cognitive functions of rapid eye movement in sleep-deprived and recovered rats
Q93004738Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury
Q39052246Hypocretins and Arousal
Q38687612Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders
Q93353809Intracerebral Adenosine During Sleep Deprivation: A Meta-Analysis and New Experimental Data
Q58697746Intracerebral microdialysis of adenosine and adenosine monophosphate - a systematic review and meta-regression analysis of baseline concentrations
Q39299450Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep
Q30362407The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.
Q34502802The Neurobiology of Sleep and Wakefulness
Q58786316The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

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