Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation

scientific article

Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.24587
P698PubMed publication ID21800344
P5875ResearchGate publication ID51531736

P50authorJesús PrietoQ28324697
Paulette Bioulac-SageQ43376282
Carmen BerasainQ39790214
P2093author name stringMaria I Demartis
Charles Balabaud
Francesco Feo
Rosa M Pascale
Jordi Muntané
Raquel Urtasun
Maria U Latasa
Maria Azcona
Maria Elizalde
Matias A Avila
Oihane Garcia-Irigoyen
Saioa Goñi
Stella Balzani
P2860cites workProapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and AktQ24296477
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
TEAD mediates YAP-dependent gene induction and growth controlQ24336045
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachQ24633776
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humansQ28251733
Hepatocellular carcinoma: epidemiology and molecular carcinogenesisQ28306363
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.Q39899643
Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell originQ39909012
Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma.Q39939616
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis.Q39960326
Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-ABCC2 antisense constructsQ40092607
Connexin 43 expression promotes malignancy of HuH7 hepatocellular carcinoma cells via the inhibition of cell-cell communicationQ40175099
Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.Q40246865
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.Q40267021
Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cellsQ40556250
Association of Vimentin overexpression and hepatocellular carcinoma metastasisQ40612642
Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblastsQ42805569
The Significance of Fibroblast Growth Factor Receptor 2 Expression in Differentiation of Hepatocellular CarcinomaQ43451322
Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway.Q45983849
Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes--but without modulating bone morphogenetic protein 7 signaling.Q51753112
Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion.Q54559632
Evidence for the Decreased Expression of the Latent TGF-β Binding Protein and its Splice Form in Human Liver TumoursQ59480296
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2Q73386407
Significance of serum connective tissue growth factor in patients with hepatocellular carcinoma and relationship with angiogenesisQ84329978
Molecular classification of hepatocellular carcinomaQ84403214
YAP1 increases organ size and expands undifferentiated progenitor cellsQ28592519
Yes-associated protein is an independent prognostic marker in hepatocellular carcinomaQ33611696
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathwayQ33644875
MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties.Q34103666
The CCN family: a new class of inflammation modulators?Q34153304
Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significanceQ36076333
Deregulation of FoxM1b leads to tumour metastasisQ36108360
Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapyQ36914691
Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop.Q37077594
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosisQ37115997
To kill a tumor cell: the potential of proapoptotic receptor agonistsQ37181734
Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytesQ37331302
The epidermal growth factor receptor: a link between inflammation and liver cancer.Q37476452
Targeting YAP and Hippo signaling pathway in liver cancerQ37764854
The role of signaling pathways in the development and treatment of hepatocellular carcinomaQ37773788
A new regulator of the cell cycle: the PR-Set7 histone methyltransferaseQ37825723
Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailabilityQ38297165
Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factorQ39620314
Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors.Q39815229
Expression, Cellular Distribution, and Prognostic Relevance of TRAIL Receptors in Hepatocellular CarcinomaQ39831266
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
connective tissueQ25615
P304page(s)2149-2158
P577publication date2011-12-01
P1433published inHepatologyQ15724398
P1476titleConnective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation
P478volume54

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cites work (P2860)
Q53826807A Randomized Phase II Open-Label Multi-Institution Study of the Combination of Bevacizumab and Erlotinib Compared to Sorafenib in the First-Line Treatment of Patients with Advanced Hepatocellular Carcinoma.
Q39172217A potential autocrine role for interferon tau in ovine trophectoderm
Q36743804Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells
Q38823799CIZ1 is upregulated in hepatocellular carcinoma and promotes the growth and migration of the cancer cells
Q37622617Cluster of differentiation 166 (CD166) regulated by phosphatidylinositide 3-Kinase (PI3K)/AKT signaling to exert its anti-apoptotic role via yes-associated protein (YAP) in liver cancer.
Q38514410Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway
Q54356882Cytoplasmic YAP expression is associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment.
Q37162642Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.
Q90323427Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor
Q43651454Dual roles of yes-associated protein (YAP) in colorectal cancer
Q26771265EGFR Signaling in Liver Diseases
Q49958316EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy.
Q37672884Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation.
Q39252001Epidermal growth factor receptor signaling in hepatocellular carcinoma: inflammatory activation and a new intracellular regulatory mechanism.
Q41260004Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells
Q42564794Hedgehog regulates yes-associated protein 1 in regenerating mouse liver
Q42784235Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis
Q89710826Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration
Q64275574High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
Q58576706Huaier Augmented the Chemotherapeutic Sensitivity of Oxaliplatin via Downregulation of YAP in Hepatocellular Carcinoma
Q38944998Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development
Q37141152Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells
Q47834790Low angiomotin-p130 with concomitant high Yes-associated protein 1 expression is associated with adverse prognosis of advanced gastric cancer
Q55516291Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis.
Q24339513MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer
Q36953540Melanoma cell adhesion molecule stimulates yes-associated protein transcription by enhancing CREB activity via c-Jun/c-Fos in hepatocellular carcinoma cells
Q34138366MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.
Q38901007MicroRNA-26b inhibits metastasis of osteosarcoma via targeting CTGF and Smad1.
Q39175087Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer
Q36273267NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
Q52674242Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks.
Q38371893Overexpression of Yes-associated protein and its association with clinicopathological features of hepatocellular carcinoma: A meta-analysis
Q37580201Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.
Q49918430Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia/reperfusion injury
Q28484499Regulation of amphiregulin gene expression by β-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system
Q38531851Regulation of hepatocyte identity and quiescence.
Q52345488Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight.
Q39173436SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
Q39016331Serine protease inhibitor Kazal type 1 promotes epithelial-mesenchymal transition through EGFR signaling pathway in prostate cancer
Q38799990Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression
Q33591632TGF-β-independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCC
Q38259755Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease.
Q38169563The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis
Q41225471The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level.
Q38903548The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer
Q91830517The YAP signaling pathway promotes the progression of lymphatic malformations through the activation of lymphatic endothelial cells
Q37108727The hippo-yes association protein pathway in liver cancer
Q38904795The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma.
Q42164554The pan-deacetylase inhibitor panobinostat modulates the expression of epithelial-mesenchymal transition markers in hepatocellular carcinoma models
Q55022572The role of Hippo signal pathway in breast cancer metastasis.
Q38151262The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma.
Q27025661The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
Q55500782Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma.
Q36237330YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14.
Q35911150YAP oncogene overexpression supercharges colon cancer proliferation
Q54977387YAP/TAZ Activation as a Target for Treating Metastatic Cancer.
Q36881080Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma
Q48171440miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis

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