YAP oncogene overexpression supercharges colon cancer proliferation

scientific article published on 15 March 2012

YAP oncogene overexpression supercharges colon cancer proliferation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CC.11.6.19453
P932PMC publication ID3335916
P698PubMed publication ID22356765
P5875ResearchGate publication ID221853448

P50authorNabeel BardeesyQ30004507
Dawang ZhouQ37382920
P2093author name stringJoseph Avruch
Nabeel Bardeesy
P2860cites workA coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)Q24293710
Yap1 acts downstream of α-catenin to control epidermal proliferationQ24294904
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cellsQ24296824
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and ExpandedQ24299457
Ajuba LIM proteins are negative regulators of the Hippo signaling pathwayQ24304074
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathwayQ24307937
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damageQ24314457
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoproteinQ24323326
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modulesQ24323939
TEAD mediates YAP-dependent gene induction and growth controlQ24336045
A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activatorQ24534123
α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1Q24613385
Hippo pathway-independent restriction of TAZ and YAP by angiomotinQ24614424
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasmQ24632716
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachQ24633776
Expression of Yes-associated protein in common solid tumorsQ24657592
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 ampliconQ24682018
WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleusQ28179264
Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAPQ28241192
Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene productQ28245300
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPQ28266862
SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in DrosophilaQ28271058
Stem cells, self-renewal, and differentiation in the intestinal epitheliumQ28294807
The WW domain: a signalling site in dystrophin?Q28306741
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart sizeQ28507019
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationQ28507317
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferationQ28507494
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestineQ28586202
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liverQ28587974
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppressionQ28591557
YAP1 increases organ size and expands undifferentiated progenitor cellsQ28592519
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.Q28972461
Elucidation of a universal size-control mechanism in Drosophila and mammalsQ29618935
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsQ29620457
Yes-associated protein is an independent prognostic marker in hepatocellular carcinomaQ33611696
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathwayQ33644875
Kibra is a regulator of the Salvador/Warts/Hippo signaling networkQ33754234
Zyxin links fat signaling to the hippo pathwayQ33930545
The WW domain protein Kibra acts upstream of Hippo in Drosophila.Q34099040
Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.Q34191953
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressorQ34207272
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programQ34244244
The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1Q34244270
The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.Q34418866
Hippo signaling: growth control and beyondQ34625638
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundanceQ35621419
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant gliomaQ35642059
In vivo regulation of Yorkie phosphorylation and localization.Q36663448
Hippo signaling in organ size controlQ36793377
Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcriptionQ37259684
Rassf family of tumor suppressor polypeptides.Q37353443
The RASSF proteins in cancer; from epigenetic silencing to functional characterizationQ37432498
Upstream regulation of the hippo size control pathwayQ37771533
Mst1/2 signalling to Yap: gatekeeper for liver size and tumour developmentQ37811893
Tissue-resident adult stem cell populations of rapidly self-renewing organsQ37812949
Molecular identification and targeting of colorectal cancer stem cellsQ37839545
Facultative stem cells in liver and pancreas: fact and fancy.Q37839897
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulationQ37880216
Deciphering tumor-suppressor signaling in flies: genetic link between Scribble/Dlg/Lgl and the Hippo pathwaysQ37950608
Hippo signaling: a hub of growth control, tumor suppression and pluripotency maintenanceQ37950609
Hippo signaling in Drosophila: recent advances and insightsQ37968995
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.Q38357857
Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.Q39514897
The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene.Q39592989
YAP is a candidate oncogene for esophageal squamous cell carcinomaQ39626574
Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.Q39637300
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator YorkieQ39872336
YAP regulates neural progenitor cell number via the TEA domain transcription factorQ39915491
Yes-associated protein (YAP) functions as a tumor suppressor in breast.Q39962753
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size controlQ40015415
The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformationQ40144929
The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signalingQ41888008
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogeneQ42064207
Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activationQ42492308
Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.Q42625092
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathwayQ47071830
Liver regenerationQ63664803
Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinomaQ82102323
Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancerQ83169055
P433issue6
P921main subjectcolon cancerQ18555025
overexpressionQ61643320
P1104number of pages7
P304page(s)1090-1096
P577publication date2012-03-15
P1433published inCell CycleQ1254166
P1476titleYAP oncogene overexpression supercharges colon cancer proliferation
P478volume11

Reverse relations

cites work (P2860)
Q36798037A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma
Q24337135A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer
Q54247052Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas.
Q38941672Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression
Q92696961Calotropin activates YAP through downregulation of LATS1 in colorectal cancer cells
Q86544507Clinical and prognostic significance of Yes-associated protein in colorectal cancer
Q51611915Clinicopathological and prognostic significance of Yes-associated protein expression in hepatocellular carcinoma and hepatic cholangiocarcinoma.
Q36304149Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade
Q34252516Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways
Q49171030Downregulation of YAP inhibits proliferation and induces apoptosis in Eca-109 cells
Q43651454Dual roles of yes-associated protein (YAP) in colorectal cancer
Q26774473Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
Q36901489Emerging roles of TEAD transcription factors and its coactivators in cancers
Q50747723Expression patterns of Oct4, Cdx2, Tead4, and Yap1 proteins during blastocyst formation in embryos of the marsupial, Monodelphis domestica Wagner.
Q37629024G-protein-coupled receptors mediate ω-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway
Q28088294Hippo/YAP pathway for targeted therapy
Q28487649Histone acetylation-mediated regulation of the Hippo pathway
Q90720640Human Colorectal Cancer from the Perspective of Mouse Models
Q38605108Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity
Q61809721Loss of Yes-associated Protein Represents an Aggressive Subtype of Colorectal Cancer
Q55516291Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis.
Q33720204Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment
Q50707850Molecular Alterations and Expression Dynamics of LATS1 and LATS2 Genes in Non-Small-Cell Lung Carcinoma.
Q35591698NDR functions as a physiological YAP1 kinase in the intestinal epithelium
Q34770004Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells
Q40545042RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer
Q36508081Restriction of intestinal stem cell expansion and the regenerative response by YAP.
Q61805753Role of inhibitor of yes-associated protein 1 in triple-negative breast cancer with taxol-based chemoresistance
Q92493288STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling
Q35885488Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients
Q47445431Significant expression of tafazzin (TAZ) protein in colon cancer cells and its downregulation by radiation.
Q34571020TAZ expression as a prognostic indicator in colorectal cancer
Q28078129Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy
Q36286883The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma.
Q36278724The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
Q37190816The clinical significance of forkhead box protein A1 and its role in colorectal cancer
Q92714964The expressions of YAP1, β-catenin and survivin in colon cancer tissues and their clinical significance
Q58768991The role of YAP/TAZ activity in cancer metabolic reprogramming
Q49923462The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines
Q27305276The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury
Q36757322Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
Q90567225Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type
Q37034046Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation
Q38814667Unraveling the expression of the oncogene YAP1, a Wnt/beta-catenin target, in adrenocortical tumors and its association with poor outcome in pediatric patients.
Q42376399Upregulation of Yes-associated protein and transcriptional co-activator with PDZ-binding motif influences the behavior of LOVO human colon adenocarcinoma cells
Q41094610VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
Q42357352WWC3: the bridge linking Hippo and Wnt pathways in lung cancer
Q36726132YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells
Q64233974YAP1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting PTEN
Q37269206Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53.
Q38733712Yes-associated protein/TEA domain family member and hepatocyte nuclear factor 4-alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice
Q34028517α-catenin. A tumor suppressor beyond adherens junctions

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