RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer

scientific article published on 14 September 2015

RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1005462977
P356DOI10.1038/ONC.2015.338
P698PubMed publication ID26364597

P2093author name stringT Wang
Y Ito
Y Chen
S J Lin
M Sudol
S C Lee
P Tan
F Zhu
Y Qiao
K G Yeoh
L S H Chuang
D C-C Voon
P2860cites workRole of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 proteinQ24294652
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt responseQ24299975
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesisQ24310469
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant actionQ24317422
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoproteinQ24323326
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modulesQ24323939
TEAD mediates YAP-dependent gene induction and growth controlQ24336045
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancerQ24337135
Runx3 inactivation is a crucial early event in the development of lung adenocarcinomaQ24339585
A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activatorQ24534123
Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancerQ39044714
YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.Q39096242
Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicityQ39296192
YAP regulates neuronal differentiation through Sonic hedgehog signaling pathwayQ39338017
Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.Q39543664
Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradationQ39672903
Fold change rank ordering statistics: a new method for detecting differentially expressed genes.Q41887389
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.Q52605847
Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.Q52652395
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.Q53318971
G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.Q54358159
Gastric cancerQ80681392
Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGFQ83473383
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genesQ83831946
Gastric cancer--an enigmatic and heterogeneous diseaseQ84156232
The evolution of antibodies into versatile tumor-targeting agentsQ95805864
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAPQ24594281
Hippo pathway-independent restriction of TAZ and YAP by angiomotinQ24614424
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasmQ24632716
Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAPQ28241192
Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene productQ28245300
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPQ28266862
Whole-genome analysis informs breast cancer response to aromatase inhibitionQ28269291
Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domainQ28272433
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated versionQ28281214
The WW domain: a signalling site in dystrophin?Q28306741
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Role of YAP/TAZ in mechanotransductionQ29615411
Elucidation of a universal size-control mechanism in Drosophila and mammalsQ29618935
RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.Q33883483
KRAS and YAP1 converge to regulate EMT and tumor survivalQ33946244
Association between RUNX3 promoter methylation and gastric cancer: a meta-analysisQ34002911
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.Q34042783
Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathwayQ34444831
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosisQ34718167
Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal disseminationQ35339610
YAP oncogene overexpression supercharges colon cancer proliferationQ35911150
Proteomic signatures of the desmoplastic invasion front reveal collagen type XII as a marker of myofibroblastic differentiation during colorectal cancer metastasisQ35987073
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domainQ36236290
RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cellsQ36413997
SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinomaQ36691348
Identification of RUNX3 as a component of the MST/Hpo signaling pathwayQ36784391
RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor αQ36971996
Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcriptionQ37259684
Oncogenic pathway combinations predict clinical prognosis in gastric cancer.Q37357165
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complexQ37623587
RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genesQ38118553
The RUNX family: developmental regulators in cancerQ38319972
VGLL4 inhibits EMT in part through suppressing Wnt/β-catenin signaling pathway in gastric cancerQ38907612
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)2664-2674
P577publication date2015-09-14
P1433published inOncogeneQ1568657
P1476titleRUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer
P478volume35

Reverse relations

cites work (P2860)
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Q90233046Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer
Q90707399Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma
Q49797899DNA binding partners of YAP/TAZ.
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Q45044138Generation of RUNX3 knockout pigs using CRISPR/Cas9-mediated gene targeting
Q91808467Hippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck
Q90142330Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity
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Q64082785New Therapeutic Approach for Targeting Hippo Signalling Pathway
Q52369044PIWIL1/piRNA-DQ593109 Regulates the Permeability of the Blood-Tumor Barrier via the MEG3/miR-330-5p/RUNX3 Axis.
Q36079567RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3.
Q55262723RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer.
Q50290763RUNX3 binds TEADs and YAP1
Q45316834RUNX3 regulates YAP1-mediated transcription
Q49853226Reciprocal regulation of YAP/TAZ by the Hippo pathway and the Small GTPase pathway.
Q28066930Repair Injured Heart by Regulating Cardiac Regenerative Signals
Q47944350Roles of RUNX in Hippo Pathway Signaling.
Q50796410Roles of RUNX in Solid Tumors.
Q47126606TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.
Q50290764TEADs:YAP1 binds CTGF gene
Q42378384The prognostic impacts of TEA domain (TEAD) transcription factor polymorphisms in Chinese hepatocellular carcinoma patients
Q37190507Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer
Q45316828Transcriptional regulation by RUNX3
Q41389363YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression

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