A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy.

scientific article

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IJC.31561
P932PMC publication ID6540999
P698PubMed publication ID29696628

P50authorMohammad Obaidul HoqueQ58472169
P2093author name stringMasahiro Shibata
Kendall Ham
P2860cites workYAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt responseQ24299975
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signallingQ24301588
The Hippo pathway regulates Wnt/beta-catenin signalingQ24307606
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancerQ24339513
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAPQ24594281
The Hippo Signaling Pathway in Development and CancerQ24603986
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 ampliconQ24682018
Cellular composition of the tumor microenvironmentQ26824910
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentQ27025661
YAP1 is a potential biomarker for cetuximab resistance in head and neck cancerQ38978179
An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.Q38982503
Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapiesQ39003420
Regulatory T cells in cancer immunotherapyQ39044365
Prognostic significance of microRNA-141 expression and its tumor suppressor function in human pancreatic ductal adenocarcinomaQ39062242
Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathwayQ39081825
YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.Q39155971
Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanismsQ39158003
YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl.Q39214406
YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29Q39246531
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.Q39303842
Yes-associated protein promotes tumour development in luminal epithelial derived breast cancerQ39447667
Myeloid suppressor cells in cancer and autoimmunityQ39448441
miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.Q39487411
Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis.Q39586964
Yes-associated protein (YAP) functions as a tumor suppressor in breast.Q39962753
The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformationQ40144929
Drosophila warts--tumor suppressor and member of the myotonic dystrophy protein kinase family.Q40475118
RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancerQ40545042
YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 SignalingQ40989829
AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells.Q41201253
Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cellsQ41260004
Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.Q41858851
Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancersQ41871593
Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesQ41957741
Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cellsQ42321651
Aerobic glycolysis tunes YAP/TAZ transcriptional activityQ35819661
Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liverQ35832927
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activationQ35868895
Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cellsQ35874350
Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patientsQ35885488
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.Q36027005
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor RegressionQ36048228
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progressionQ36086980
COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cellsQ36110362
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.Q36134167
YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14.Q36237330
YAP activation protects urothelial cell carcinoma from treatment-induced DNA damageQ36414976
Targeting YAP-Dependent MDSC Infiltration Impairs Tumor ProgressionQ36447669
Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factorsQ36455404
Expression of tumoral FOXP3 in gastric adenocarcinoma is associated with favorable clinicopathological variables and related with Hippo pathwayQ36464531
Yes associated protein is a poor prognostic factor in well-differentiated lung adenocarcinomaQ36511765
Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunityQ36710977
YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cellsQ36726132
Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinomaQ36881080
Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cellsQ36916380
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapiesQ37058831
PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environmentQ37193568
Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cellQ37427970
MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1Q37457780
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.Q37486949
YAP promotes erlotinib resistance in human non-small cell lung cancer cellsQ37588390
YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteinsQ37623308
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complexQ37623587
YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cellsQ37706137
Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.Q37707464
The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysisQ37820803
Hippo signaling in Drosophila: recent advances and insightsQ37968995
History of myeloid-derived suppressor cellsQ38141522
Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinomaQ38401343
Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance.Q38415215
YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling AxisQ38437859
The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications.Q38542016
YAP and TAZ Take Center Stage in CancerQ38606718
Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapyQ38641116
Hippo pathway and breast cancer stem cellsQ38685431
Lung cancer stem cells: The root of resistanceQ38706873
SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer ProgressionQ38708096
The expanding role of immunotherapy.Q38754012
Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling.Q38784875
MiR-497 Suppresses YAP1 and Inhibits Tumor Growth in Non-Small Cell Lung CancerQ38840124
Hsa-miR-132 inhibits proliferation of hepatic carcinoma cells by targeting YAP.Q38861530
Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo PathwayQ38882539
MicroRNA-506 inhibits gastric cancer proliferation and invasion by directly targeting Yap1.Q38890422
The Hippo pathway transcriptional co-activator, YAP, confers resistance to cisplatin in human oral squamous cell carcinomaQ38890549
YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like CellsQ38901912
The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal CancerQ38903548
Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expressionQ38941672
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repressionQ38966843
YAP activation is an early event and a potential therapeutic target in liver cancer development.Q38976729
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.Q27310763
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi ResistanceQ27853210
Immunity, Inflammation, and CancerQ27861048
PD-1 and its ligands are important immune checkpoints in cancerQ28069485
Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor MicroenvironmentQ28071935
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
YAP/TEAD co-activator regulated pluripotency and chemoresistance in ovarian cancer initiated cellsQ28250934
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1Q28282333
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationQ28507317
Role of YAP/TAZ in mechanotransductionQ29615411
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancerQ29616360
The Hippo signaling pathway in stem cell biology and cancerQ30410176
Expression and clinical significance of YAP, TAZ, and AREG in hepatocellular carcinomaQ33594370
Yes-associated protein is an independent prognostic marker in hepatocellular carcinomaQ33611696
Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammationQ33676412
COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC functionQ33678308
YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.Q33757057
Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancerQ33898459
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancerQ33943271
KRAS and YAP1 converge to regulate EMT and tumor survivalQ33946244
MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties.Q34103666
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinomaQ34246014
M1 and M2 Macrophages: Oracles of Health and DiseaseQ34328890
Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.Q34358867
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapyQ34522172
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cellsQ34784887
Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladderQ34840601
The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activationQ34979150
Increased expression of Yes-associated protein 1 in hepatocellular carcinoma with stemness and combined hepatocellular-cholangiocarcinomaQ35005633
Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen responseQ35100037
Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma.Q35127831
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.Q35553327
R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical ActionabilityQ35657635
The Hippo-YAP pathway: new connections between regulation of organ size and cancerQ35811415
Metaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer.Q42467629
Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patientsQ42789703
miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1.Q42809008
Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE₂ catabolism in myeloid cells.Q43001771
Generation of myeloid-derived suppressor cells using prostaglandin E2.Q43110927
Differential expression of Yes-associated protein and phosphorylated Yes-associated protein is correlated with expression of Ki-67 and phospho-ERK in colorectal adenocarcinomaQ44253428
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferationQ46192247
PRKCI promotes immune suppression in ovarian cancerQ47154650
Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinomaQ47864262
Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancerQ48370038
YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like CellsQ48588772
YAP regulates PD-L1 expression in human NSCLC cellsQ49569691
YAP-1 Promotes Tregs Differentiation in Hepatocellular Carcinoma by Enhancing TGFBR2 Transcription.Q50672880
Nuclear accumulation of Yes-Associated Protein (YAP) maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression.Q50872491
Loss of MiR-424-3p, not miR-424-5p, confers chemoresistance through targeting YAP1 in non-small cell lung cancer.Q51474565
Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts.Q52353619
Metabolic control of YAP and TAZ by the mevalonate pathway.Q52768568
Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.Q53730688
The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway.Q54336219
Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancerQ83169055
Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factorsQ85465848
RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB PathwayQ87063270
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectimmunosuppressionQ1455316
P304page(s)2133-2144
P577publication date2018-04-26
P1433published inInternational Journal of CancerQ332492
P1476titleA time for YAP1: Tumorigenesis, immunosuppression and targeted therapy.
P478volume143

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cites work (P2860)
Q92812554Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer
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Q58796939miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression

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