Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels

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Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels is …
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scholarly articleQ13442814

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P356DOI10.1007/S00125-011-2414-Z
P698PubMed publication ID22222503
P5875ResearchGate publication ID221726894

P50authorLuke NortonQ51373612
Ralph A. DeFronzoQ58689309
P2093author name stringW Hu
B Doiron
P2860cites workPhosphorylation of grb10 regulates its interaction with 14-3-3Q24295241
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domainsQ24315001
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14Q27656836
Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 poolQ28139493
Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose toleranceQ46126827
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?Q46736684
Capacity to secrete islet hormones after subtotal pancreatectomy for pancreatic cancer.Q51601381
Reduced insulin secretion by subtotal pancreatectomy: preservation of insulin sensitivity and glucose tolerance in postoperative patients.Q51615321
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in KoreaQ57214866
Glucoregulation during insulin and glucagon deficiency: role of catecholaminesQ72533926
Evidence against GRB10 as the gene responsible for Silver-Russell syndromeQ74438203
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose toleranceQ77652485
Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell massQ83207600
Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signalingQ28289183
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesQ28506930
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4Q28507095
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopyQ30853783
Grb10 interacts with Bim L and inhibits apoptosisQ33533399
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.Q34059976
Major DNA fragmentation is a late event in apoptosisQ34431596
Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Q34512913
Hyperglucagonemia and insulin-mediated glucose metabolismQ34560371
The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetesQ34655580
Metabolic and molecular basis of insulin resistanceQ35148800
The BCL-2 family reunionQ35568029
Studies of pancreatic alpha cell function in normal and diabetic subjectsQ35576866
Grb10 exceeding the boundaries of a common signaling adapter.Q35650904
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysisQ35995063
Grb10 and Grb14: enigmatic regulators of insulin action--and more?Q36131371
The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implicationsQ36780425
The replication of beta cells in normal physiology, in disease and for therapyQ36978813
Preservation of beta-cell function by targeting beta-cell massQ37116279
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vectorQ37251114
Current strategies for the inhibition of hepatic glucose production in type 2 diabetesQ37410100
Adaptation of the exocrine pancreas to dietQ37946535
The biochemistry of cell death by apoptosisQ38008685
Grb10 and active Raf-1 kinase promote Bad-dependent cell survivalQ40126556
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetesQ40156533
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferationQ40742143
Lentiviral vectors--the promise of gene therapy within reach?Q40934408
Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology StudyQ43959543
Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.Q44117925
Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabeticsQ44183858
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) studyQ44686996
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysisQ45105931
Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivoQ45877035
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectorsQ45884182
Impaired glucose-induced glucagon suppression after partial pancreatectomy.Q45985373
P433issue3
P921main subjectpancreasQ9618
GlucoseQ37525
glycobiologyQ899224
glucagonQ28163629
P304page(s)719-728
P577publication date2012-01-07
P1433published inDiabetologiaQ5270140
P1476titleLentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels
P478volume55