The insulin gene contains multiple transcriptional elements that respond to glucose

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The insulin gene contains multiple transcriptional elements that respond to glucose is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.14.6.4067
P932PMC publication ID358772
P698PubMed publication ID8196645

P2093author name stringJ Wang
M S German
P2860cites workA new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteinsQ24299387
Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary historyQ24338152
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory systemQ24594825
The simian virus 40 small-t intron, present in many common expression vectors, leads to aberrant splicingQ24634564
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cellsQ27860607
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivoQ28306976
Cell-type-specific contacts to immunoglobulin enhancers in nucleiQ28307043
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domainQ28564170
Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cellsQ31009822
Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I geneQ31171099
Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin EnhancerQ33263393
A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancerQ33580583
A cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin geneQ33981133
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complexQ34244863
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancerQ34375782
Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediatesQ36130834
Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promotersQ36268104
Nucleotide sequences of integrated Moloney sarcoma provirus long terminal repeats and their host and viral junctionsQ36396830
Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequenceQ36755529
Cooperativity of sequence elements mediates tissue specificity of the rat insulin II geneQ36756394
Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elementsQ36758591
Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cellsQ36764691
Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcriptionQ36766829
Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivatorsQ36790901
c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elementsQ36817615
Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteinsQ36961228
Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family.Q38318299
Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genesQ38327650
Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytesQ40505363
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexesQ40678585
Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II geneQ41665716
Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cellsQ41676218
Positive and negative regulation of the human insulin gene by multiple trans-acting factorsQ41734176
Functional characterization of a cAMP-responsive element of the rat insulin I geneQ41747359
Effects of D-glucose, L-leucine, and 2-ketoisocaproate on insulin mRNA levels in mouse pancreatic isletsQ42521292
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenesQ43470250
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elementsQ43524876
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifsQ46718044
Regulation of insulin gene expression by glucose and calcium in transfected primary islet culturesQ46757812
Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genesQ59057041
Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary cultureQ69352145
Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasoneQ69809705
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stabilityQ69913598
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNAQ70105970
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectglycobiologyQ899224
preproinsulinQ7240673
P304page(s)4067-4075
P577publication date1994-06-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe insulin gene contains multiple transcriptional elements that respond to glucose
P478volume14