Mice overexpressing the gene for heparin-binding epidermal growth factor-like growth factor (HB-EGF) have increased resistance to hemorrhagic shock and resuscitation

scientific article published on October 20, 2010

Mice overexpressing the gene for heparin-binding epidermal growth factor-like growth factor (HB-EGF) have increased resistance to hemorrhagic shock and resuscitation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SURG.2010.08.003
P953full work available at URLhttps://europepmc.org/articles/pmc3022082?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20965535/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20965535/pdf/?tool=EBI
https://europepmc.org/articles/PMC3022082
https://europepmc.org/articles/PMC3022082?pdf=render
https://api.elsevier.com/content/article/PII:S0039606010004472?httpAccept=text/xml
https://doi.org/10.1016/j.surg.2010.08.003
https://api.elsevier.com/content/article/PII:S0039606010004472?httpAccept=text/plain
P932PMC publication ID3022082
P698PubMed publication ID20965535
P5875ResearchGate publication ID47519325

P50authorChun-Liang ChenQ92465302
P2093author name stringAndrei Radulescu
Hong-yi Zhang
Gail E. Besner
Jacob K. Olson
Amanda K. Darbyshire
P2860cites workA Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGFQ24319855
N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migrationQ24535534
Diphtheria ToxinQ28268924
p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascadesQ28362225
Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivityQ28631171
Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cellsQ33887579
Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.Q34317276
Ischemia-reperfusion injury of the intestine and protective strategies against injuryQ35916693
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways.Q35994805
Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in miceQ36808906
Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cellsQ37151646
Intestinal phenotype in mice overexpressing a heparin-binding EGF-like growth factor transgene in enterocytesQ37289601
Heparin-binding epidermal growth factor-like growth factor is essential for preservation of gut barrier function after hemorrhagic shock and resuscitation in miceQ37367909
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymeraseQ37429030
Epithelial tight junctions in intestinal inflammationQ37524296
Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.Q38358504
Deletion of the heparin-binding epidermal growth factor-like growth factor gene increases susceptibility to necrotizing enterocolitisQ40033966
Inhibition of NF-kappa B activation and its target genes by heparin-binding epidermal growth factor-like growth factorQ40614096
Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivoQ40633877
Isolation and characterization of a macrophage-derived heparin-binding growth factor.Q40647293
Upregulation of endogenous heparin-binding EGF-like growth factor (HB-EGF) expression after intestinal ischemia/reperfusion injuryQ40648030
Gut ischaemiaQ40723965
Heparin-binding epidermal growth factor-like growth factor protects rat intestine from ischemia/reperfusion injuryQ40786052
Heparin-binding epidermal growth factor–like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitisQ42093441
Heparin-binding EGF-like growth factor decreases inflammatory cytokine expression after intestinal ischemia/reperfusion injuryQ42726930
Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfateQ42769676
Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomyQ44337885
Heparin-binding epidermal growth factor-like growth factor decreases the incidence of necrotizing enterocolitis in neonatal ratsQ46892677
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.Q52118607
Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis.Q53630464
HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation.Q54650079
HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis.Q54795142
Heparin-Binding EGF-Like Growth Factor Down Regulates Proinflammatory Cytokine-Induced Nitric Oxide and Inducible Nitric Oxide Synthase Production in Intestinal Epithelial CellsQ57450777
Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisalQ71537631
Upregulation of endogenous heparin-binding EGF-like growth factor and its role as a survival factor in skeletal myotubesQ73047425
Heparin-binding EGF-like growth factor downregulates expression of adhesion molecules and infiltration of inflammatory cells after intestinal ischemia/reperfusion injuryQ73114692
Heparin-binding EGF-like growth factor preserves mesenteric microcirculatory blood flow and protects against intestinal injury in rats subjected to hemorrhagic shock and resuscitationQ80774830
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecthemorrhagic shockQ2964243
resuscitationQ5491454
overexpressionQ61643320
P304page(s)276-283
P577publication date2010-10-20
P1433published inSurgeryQ15731526
P1476titleMice overexpressing the gene for heparin-binding epidermal growth factor-like growth factor (HB-EGF) have increased resistance to hemorrhagic shock and resuscitation
P478volume149

Reverse relations

cites work (P2860)
Q39513204Creating a flexible multiple microRNA expression vector by linking precursor microRNAs
Q54458115HB-EGF promotes intestinal restitution by affecting integrin-extracellular matrix interactions and intercellular adhesions.
Q35141090HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity
Q37009351Heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from radiation therapy-induced intestinal injury
Q38380575Heparin-binding EGF-like growth factor (HB-EGF) therapy for intestinal injury: Application and future prospects
Q42325850Heparin-binding epidermal growth factor-like growth factor and mesenchymal stem cells act synergistically to prevent experimental necrotizing enterocolitis
Q36614045Heparin-binding epidermal growth factor-like growth factor improves intestinal barrier function and reduces mortality in a murine model of peritonitis

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