Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate.

scientific article published on February 2009

Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BPJ.2008.10.029
P932PMC publication ID2717256
P698PubMed publication ID19217865
P5875ResearchGate publication ID24011114

P50authorMartin WeikQ28321250
Patrick MassonQ42732222
Frank GabelQ51016637
P2093author name stringG Zaccai
I Silman
A Saxena
B P Doctor
M-T Froment
P2860cites workEnzyme-catalyzed processes in organic solventsQ24567816
Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoningQ24683895
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic levelQ27618409
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and productsQ27641694
The alpha/beta hydrolase foldQ28156084
Evolution of the internal dynamics of two globular proteins from dry powder to solution.Q30322770
How soft is a protein? A protein dynamics force constant measured by neutron scattering.Q30326855
Neurobiology of butyrylcholinesterase.Q35058510
Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacologyQ36134380
Protein dynamics: comparison of simulations with inelastic neutron scattering experimentsQ36820082
Protein flexibility from the dynamical transition: a force constant analysisQ39263966
Conformational substates in proteinsQ39653528
The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study.Q40281590
Bioscavengers for the protection of humans against organophosphate toxicityQ40372121
Anticholinesterases: medical applications of neurochemical principles.Q40509398
Mouse acetylcholinesterase unliganded and in complex with huperzine A: a comparison of molecular dynamics simulationsQ41667437
Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study.Q42101924
Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressuresQ42994766
Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic ModelQ44644039
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasmaQ46742699
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmisQ48325738
Ligand stabilization of cholinesterasesQ69774838
Evidence that the conformational stability of 'aged' organophosphate-inhibited cholinesterase is alteredQ70012559
Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drugQ73402708
Protein dynamics in solution and powder measured by incoherent elastic neutron scattering: the influence of Q-range and energy resolutionQ80587302
Capillary electrophoresis versus differential scanning calorimetry for the analysis of free enzyme versus enzyme-ligand complexes: in the search of the ligand-free status of cholinesterasesQ81603173
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsomanQ408044
P304page(s)1489-1494
P577publication date2009-02-01
P1433published inBiophysical JournalQ2032955
P1476titleDirect correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate
P478volume96