Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions

scientific article published on December 2008

Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/187152208787169233
P932PMC publication ID2771939
P698PubMed publication ID19956793
P5875ResearchGate publication ID40443875

P2093author name stringWilliam Rodgers
Corey M Johnson
P2860cites workAutoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome proteinQ22253357
Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositidesQ24291063
Vinculin--a dynamic regulator of cell adhesionQ24308712
F-actin binding site masked by the intramolecular association of vinculin head and tail domainsQ24309102
A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinaseQ24321384
Signal-dependent membrane targeting by pleckstrin homology (PH) domainsQ24532099
Triton promotes domain formation in lipid raft mixturesQ24537567
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domainQ24598762
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesionQ27939824
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formationQ28139699
Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signalingQ28189437
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesionsQ28214350
Pleckstrin domain homologyQ28269367
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complexQ28293934
Focal adhesions, contractility, and signalingQ28299775
PIP3, PIP2, and cell movement--similar messages, different meanings?Q28366133
A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signalsQ28579260
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinasesQ29614248
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblastsQ29614253
Cell migration: Rho GTPases lead the wayQ29616711
Inositol trisphosphate, a novel second messenger in cellular signal transductionQ29618048
ERM proteins and merlin: integrators at the cell cortexQ29619893
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.Q30193575
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.Q30194078
Dissecting the gelsolin-polyphosphoinositide interaction and engineering of a polyphosphoinositide-sensitive gelsolin C-terminal half protein.Q30331772
Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteinsQ30447412
ARF1-mediated actin polymerization produces movement of artificial vesiclesQ30480259
Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cellsQ30504629
Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete proteinQ31914621
Phosphoinositides in membrane traffic at the synapseQ32066953
The Arp2/3 complex: a multifunctional actin organizerQ33536484
Signaling pathways in phagocytosisQ33665066
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activationQ33874977
ERM-Merlin and EBP50 protein families in plasma membrane organization and functionQ34059680
The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P(2) influences cytoskeletal protein activity at the plasma membraneQ34062572
Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnoverQ34067259
Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membraneQ34233461
Phosphatidylinositol Phosphate Kinases Put PI4,5P 2 in Its PlaceQ34264164
Cell migration in invertebrates: clues from border and distal tip cellsQ34305817
The role of phosphoinositides in membrane transportQ34309086
PI(4,5)P(2) regulation of surface membrane trafficQ34309091
Phospholipid signalingQ34317077
The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinasesQ34318366
Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding siteQ34408635
PIP(2) and proteins: interactions, organization, and information flowQ34623576
The MARCKS brothers: a family of protein kinase C substratesQ35476852
Signaling with phosphoinositides: better than binary.Q35679366
Reversible - through calmodulin - electrostatic interactions between basic residues on proteins and acidic lipids in the plasma membraneQ36008631
Merging complexes: properties of membrane raft assembly during lymphocyte signalingQ36018987
Probing phosphoinositide functions in signaling and membrane trafficking.Q36113257
Role of GAP-43 in sequestering phosphatidylinositol 4,5-bisphosphate to Raft bilayersQ36259531
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosisQ36293644
Genetic, biochemical and structural approaches to talin functionQ36295415
A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.Q36320696
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosisQ36321631
Lymphocyte calcium signaling from membrane to nucleusQ36343541
Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.Q36542078
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acidQ36565713
Target-specific PIP(2) signalling: how might it work?Q36782546
Molecular mechanisms of CD4+ T-cell anergyQ36870857
Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatasesQ39947692
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cellsQ40021756
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.Q40197369
Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domainsQ40242663
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.Q40499969
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.Q40704860
Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1.Q40744874
Phosphatidylinositol 4-phosphate synthesis in immunoisolated caveolae-like vesicles and low buoyant density non-caveolar membranesQ41030532
Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domainsQ41157478
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogeneQ41358116
The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphateQ41750994
The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cellQ41971189
PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motilityQ42145207
The Ca2(+)-dependent actin filament-severing activity of 74-kDa protein (adseverin) resides in its NH2-terminal halfQ42621674
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.Q42803796
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphateQ42812246
The sensitivity of lipid domains to small perturbations demonstrated by the effect of TritonQ44466078
Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomainsQ44664081
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cellsQ46524862
Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamicsQ46817796
Clustering of membrane raft proteins by the actin cytoskeletonQ46942391
Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.Q48077144
Phosphorylation and activation of mitogen-activated protein kinase by kainic acid-induced seizure in rat hippocampusQ48087340
PIPkins1, their substrates and their products: new functions for old enzymesQ48566438
Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphateQ59072772
ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugationQ63408325
A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of ThymocytesQ63408334
Functional comparison of villin and gelsolin. Effects of Ca2+, KCl, and polyphosphoinositidesQ69841081
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human plateletsQ72033892
Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivoQ73144349
Importance of protein kinase C targeting for the phosphorylation of its substrate, myristoylated alanine-rich C-kinase substrateQ73854898
MARCKS, membranes, and calmodulin: kinetics of their interactionQ77521416
Talin1 regulates TCR-mediated LFA-1 functionQ79370181
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokinesQ81657102
P433issue4
P304page(s)349-357
P577publication date2008-12-01
P1433published inImmunology, endocrine & metabolic agents in medicinal chemistryQ27722427
P1476titleSpatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions
P478volume8

Reverse relations

cites work (P2860)
Q57464729A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
Q36864524Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin
Q89682561High-Cholesterol Diet Decreases the Level of Phosphatidylinositol 4,5-Bisphosphate by Enhancing the Expression of Phospholipase C (PLCβ1) in Rat Brain
Q47774296Interplay between membrane elasticity and active cytoskeleton forces regulates the aggregation dynamics of the immunological synapse.
Q36413719Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.
Q36911466Localization of phosphatidylinositol 4,5-bisphosphate to lipid rafts and uroids in the human protozoan parasite Entamoeba histolytica
Q38111276Regulation of ion channels by membrane lipids

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