Interaction between external Na+ and mexiletine on Na+ channel in guinea-pig ventricular myocytes

scientific article published on November 1995

Interaction between external Na+ and mexiletine on Na+ channel in guinea-pig ventricular myocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF00374382
P698PubMed publication ID8584406

P2093author name stringM Hiraoka
M Ono
A Sunami
P2860cites workBlockage of the sodium current in isolated single cells from rat ventricle with mexiletine and disopyramide.Q51827999
Different temperature sensitivity of cardiac Na+ channels in cell-attached and cell-free conditions.Q52483568
Modulation of flecainide's cardiac sodium channel blocking actions by extracellular sodium: a possible cellular mechanism for the action of sodium salts in flecainide cardiotoxicityQ72956961
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugsQ30449316
A Classification of Antiarrhythmic Actions Reassessed After a Decade of New DrugsQ34248170
Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytesQ34261644
Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassificationQ34713819
Effect of N-bromoacetamide on single sodium channel currents in excised membrane patchesQ36409207
Kinetic properties of single sodium channels in rat heart and rat brainQ36410110
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxinQ40300883
Inactivation of sodium channels: second order kinetics in myelinated nerveQ40668698
External site for local anesthetic block of cardiac Na+ channels*1Q41129342
Molecular determinants of state-dependent block of Na+ channels by local anestheticsQ42284240
Use-dependent block of Na+ currents by mexiletine at the single channel level in guinea-pig ventricular myocytesQ42759890
Block of single cardiac Na+ channels by antiarrhythmic drugs: the effect of amiodarone, propafenone and diprafenoneQ43683887
Barium-induced automatic activity in isolated ventricular myocytes from guinea-pig heartsQ46299128
External pH modifies sodium channel block by mexiletine in guinea pig ventricular myocytesQ46565095
Negative shift of cardiac Na+ channel kinetics in cell-attached patch recordingsQ46608761
Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state?Q51652331
Dual effect of the local anaesthetic penticainide on the Na+ current of guinea-pig ventricular myocytes.Q51714660
Two components of use-dependent block of Na+ current by disopyramide and lidocaine in guinea pig ventricular myocytesQ51716345
Blockade of cardiac sodium channels by lidocaine. Single-channel analysis.Q51747237
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)101-109
P577publication date1995-11-01
P1433published inPfluegers ArchivQ1091689
P1476titleInteraction between external Na+ and mexiletine on Na+ channel in guinea-pig ventricular myocytes
P478volume431

Reverse relations

cites work (P2860)
Q53943964Antiarrhythmic drugs and cardiac ion channels: mechanisms of action.
Q37365724Pharmacological targeting of long QT mutant sodium channels
Q36782181Probing kinetic drug binding mechanism in voltage-gated sodium ion channel: open state versus inactive state blockers

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