Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes.

scientific article published on 4 November 2010

Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00125-010-1956-9
P932PMC publication ID3795617
P698PubMed publication ID21052977
P5875ResearchGate publication ID47680511

P50authorAdrian AnghelQ80010846
P2093author name stringY Wang
Y Liu
L Liu
W Wang
Y Nakagawa
T C Friedman
X Ren
K Lutfy
P2860cites workTargeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esteraseQ22009536
The glucose-6-phosphatase systemQ24533844
Obesity and insulin resistanceQ24607078
Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expressionQ28116645
The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membraneQ28144963
Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid actionQ28204909
Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complexQ28214516
Does central obesity reflect "Cushing's disease of the omentum"?Q28236784
Increased 11beta-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in uteroQ28578232
Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomesQ28582249
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis FunctionQ28592552
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic miceQ33782682
Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b.Q33852573
Obesity and cortisolQ34071860
A transgenic model of visceral obesity and the metabolic syndromeQ34104691
Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in miceQ34197575
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiencyQ34213892
Minireview: hexose-6-phosphate dehydrogenase and redox control of 11{beta}-hydroxysteroid dehydrogenase type 1 activityQ34404014
Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenaseQ36348410
Insulin and dexamethasone dynamically regulate adipocyte 11beta-hydroxysteroid dehydrogenase type 1.Q36796725
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stressQ36833926
Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob miceQ38354307
Successful treatment of Cushing's syndrome with the glucocorticoid antagonist RU 486.Q38536054
Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductaseQ40530959
11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulatedQ41036334
Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoidsQ41083075
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progressionQ41986400
Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) miceQ42022174
Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitusQ42458833
Glucocorticoids activate transcription of the gene for the glucose-6-phosphate transporter, deficient in glycogen storage disease type 1b.Q42510236
Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activityQ42800815
Metyrapone prevents cortisone-induced preadipocyte differentiation by depleting luminal NADPH of the endoplasmic reticulumQ42811022
Bezafibrate regulates the expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytesQ42832571
Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetesQ43294319
Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic miceQ44219623
Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.Q44273298
11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesityQ44273319
Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.Q44794232
Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulumQ44848212
Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db miceQ45199118
Adipose tissue 11-beta-Hydroxysteroid Dehydrogenase Type 1 and Hexose-6-Phosphate Dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitusQ46285569
Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker ratsQ46442907
Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generationQ46852972
Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environmentQ46864538
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese miceQ47341892
Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice.Q51571825
Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action.Q54524505
11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulationsQ61865428
11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicityQ71038967
Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposityQ74619299
The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissueQ79782412
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)440-450
P577publication date2010-11-04
P1433published inDiabetologiaQ5270140
P1476titleTissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes
P478volume54

Reverse relations

cites work (P2860)
Q3480097611β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue
Q36179979A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding
Q42540788Amphetamine withdrawal differentially affects hippocampal and peripheral corticosterone levels in response to stress
Q89455940Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes
Q35106896Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models
Q51188763Effect of Mifepristone on Corticosteroid Production in Vitro by Adrenal Glands of Rats with Streptozotocin Diabetes.
Q28541028Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats
Q52641727Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity.
Q37146798Increased glycogen synthase kinase-3β and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposity
Q48019755Interplay between H6PDH and 11β-HSD1 implicated in the pathogenesis of type 2 diabetes mellitus
Q36439638Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.
Q42602503Liver glucose-6-phosphatase proteins in suckling and weaned grey seal pups: structural similarities to other mammals and relationship to nutrition, insulin signalling and metabolite levels
Q54345628Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients.
Q27302419Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity
Q39220866Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice
Q37629023Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice

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