| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.270.28.16854 |
| P698 | PubMed publication ID | 7622501 |
| P2093 | author name string | Jain AK | |
| Dunn KE | |||
| Gibbs CS | |||
| Leung LL | |||
| Tsiang M | |||
| Rojas ME | |||
| P2860 | cites work | Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation | Q24337851 |
| The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships | Q27642041 | ||
| The structure of a complex of recombinant hirudin and human alpha-thrombin | Q27684792 | ||
| Rapid and efficient site-specific mutagenesis without phenotypic selection | Q27860628 | ||
| The interpretation of protein structures: Estimation of static accessibility | Q27860750 | ||
| Cofactor proteins in the assembly and expression of blood clotting enzyme complexes | Q28289123 | ||
| Production of single-stranded plasmid DNA | Q29547328 | ||
| The interaction of thrombin with fibrinogen. A structural basis for its specificity | Q34416186 | ||
| Factor XI activation in a revised model of blood coagulation | Q34500136 | ||
| Selection of single-stranded DNA molecules that bind and inhibit human thrombin | Q34616171 | ||
| Molecular mapping of the heparin-binding exosite of thrombin | Q35478768 | ||
| Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin | Q36597580 | ||
| Incorporation of a charged amino acid into the membrane-spanning domain blocks cell surface transport but not membrane anchoring of a viral glycoprotein | Q36890683 | ||
| Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species | Q36921502 | ||
| Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin | Q37565691 | ||
| Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin | Q37582778 | ||
| Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues. | Q38338187 | ||
| Spatial structure of thrombin as a guide to its multiple sites of interaction. | Q40731374 | ||
| A model for the specificity of fibrinogen cleavage by thrombin. | Q40731385 | ||
| Deciphering the message in protein sequences: tolerance to amino acid substitutions | Q45038796 | ||
| The independent distribution of amino acid near neighbor pairs into polypeptides | Q52806859 | ||
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| P433 | issue | 28 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 16854-16863 | |
| P577 | publication date | 1995-07-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Functional mapping of the surface residues of human thrombin | |
| P478 | volume | 270 |
| Q45213010 | A critical role for Gly25 in the B chain of human thrombin. |
| Q35594671 | A guided mode resonance aptasensor for thrombin detection |
| Q24816305 | A novel method of screening thrombin-inhibiting DNA aptamers using an evolution-mimicking algorithm |
| Q43581648 | An extensive interaction interface between thrombin and factor V is required for factor V activation |
| Q28481282 | Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins |
| Q27660588 | Combinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin Fold |
| Q27660263 | Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1 |
| Q36851953 | Crystal structure of the complex between thrombin and the central "E" region of fibrin |
| Q27646532 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4 |
| Q36819410 | Design of Factor XIII V34X activation peptides to control ability to interact with thrombin mutants |
| Q36293491 | Determinants of specificity in coagulation proteases |
| Q43050009 | Directed mutagenesis identifies amino acid residues involved in elongation factor Tu binding to yeast Phe-tRNAPhe |
| Q44562077 | Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin |
| Q33911257 | Engineering thrombin for selective specificity toward protein C and PAR1. |
| Q36884329 | Exosites in the substrate specificity of blood coagulation reactions |
| Q24338455 | Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes |
| Q46409985 | Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin |
| Q38308474 | HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase |
| Q37389555 | Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality |
| Q34192168 | Identification and characterization of novel salivary thrombin inhibitors from the ixodidae tick, Haemaphysalis longicornis |
| Q37037369 | Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa |
| Q42314217 | Marine Diterpenes: Molecular Modeling of Thrombin Inhibitors with Potential Biotechnological Application as an Antithrombotic. |
| Q27646504 | Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A |
| Q27656902 | Molecular basis of thrombomodulin activation of slow thrombin |
| Q28275459 | Molecular mapping of the thrombin-heparin cofactor II complex |
| Q33221756 | Molecular recognition mechanisms of thrombin |
| Q59129687 | Nanogravimetric and Optical Characterizations of Thrombin Interaction with a Self-Assembled Thiolated Aptamer |
| Q40647381 | Proexosite-1 on Prothrombin Is a Factor Va-dependent Recognition Site for the Prothrombinase Complex |
| Q35804490 | Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. |
| Q36610450 | Role of Na+ and K+ in enzyme function |
| Q33177672 | Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator |
| Q53585324 | Role of surface residue 184 in the catalytic activity of NADH oxidase from Streptococcus pyogenes. |
| Q52860167 | Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate. |
| Q36690512 | Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Using in Vitro Genetics |
| Q38297955 | Stability and binding properties of a modified thrombin binding aptamer |
| Q40541604 | Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling |
| Q27667771 | Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction |
| Q37893582 | Structural basis of thrombin-protease-activated receptor interactions |
| Q27746396 | Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug |
| Q34750443 | Switching cation-binding loops paves the way for redesigning allosteric activation |
| Q42610978 | The Contribution of Amino Acid Region Asp695-Tyr698 of Factor V to Procofactor Activation and Factor Va Function |
| Q35674094 | The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin |
| Q92907664 | The protein C activator AB002 rapidly interrupts thrombus development in baboons |
| Q36538501 | The role of thrombin exosites I and II in the activation of human coagulation factor V. |
| Q53626760 | The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII. |
| Q40724533 | The thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I. |
| Q36800534 | Thrombin |
| Q38989460 | Thrombin a-chain: activation remnant or allosteric effector? |
| Q45063820 | Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively |
| Q33328373 | Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites |
| Q40932840 | Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains |
| Q33879440 | Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke |
| Q27670605 | Thrombin-aptamer recognition: a revealed ambiguity |
| Q36348107 | Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin |
| Q45176583 | Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. |
| Q38302468 | Towards maintenance-free biosensors for hundreds of bind/release cycles |
| Q39272683 | Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA. |
| Q27675420 | Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector |
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