The role of B cell antigen receptors in mantle cell lymphoma.

scientific article published on 17 October 2017

The role of B cell antigen receptors in mantle cell lymphoma. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1092249054
P356DOI10.1186/S13045-017-0533-9
P932PMC publication ID5646121
P698PubMed publication ID29041946

P50authorMichael FichtnerQ57421969
Martin TrepelQ88340222
P2093author name stringMartin Dreyling
Mascha Binder
P2860cites workHistopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL NetworkQ44135718
Cyclin D1-negative mantle cell lymphomaQ44179538
Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentityQ45141844
Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the EurQ45182734
Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: resQ45236772
Rituximab after Autologous Stem-Cell Transplantation in Mantle-Cell Lymphoma.Q47736956
Lymphoma-associated translocation t(14;18) in blood B cells of normal individualsQ48074034
Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ50205176
Molecular components of the B-cell antigen receptor complex of the IgM classQ50335807
Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence.Q51027142
Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.Q52013904
Somatic hypermutation and V(H) gene usage in mantle cell lymphoma.Q52940574
Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations.Q52947124
Bendamustine-rituximab in mantle cell lymphoma.Q52947485
Molecular evidence for antigen drive in the natural history of mantle cell lymphoma.Q52953600
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis.Q53029323
Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur.Q53129637
Cyclin D1-negative mantle cell lymphoma with cryptic t(12;14)(p13;q32) and cyclin D2 overexpressionQ57580345
Genomic and epigenomic co-evolution in follicular lymphomasQ60345277
Immunoglobulin genesQ70520549
BCL-2/JH rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseasesQ71121151
Detection of cyclin D1 (bcl-1, PRAD1) overexpression by a simple competitive reverse transcription-polymerase chain reaction assay in t(11;14)(q13;q32)-bearing B-cell malignancies and/or mantle cell lymphomaQ73062541
Immunoglobulin light chain kappa deletion rearrangement as a marker of clonality in mantle cell lymphomaQ73307419
Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signalingQ83587583
Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptorQ24597028
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemiaQ24599100
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphomaQ24613755
Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activityQ24656700
Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal ToxinQ24673297
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Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteinsQ27635202
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Innate immune recognitionQ27860721
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A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphomaQ28254924
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signallingQ28272891
Aggressive lymphomasQ28279743
Virus-encoded superantigensQ28776748
Somatic generation of antibody diversityQ29616439
Predominant autoantibody production by early human B cell precursorsQ29619656
Postibrutinib outcomes in patients with mantle cell lymphomaQ30277756
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphomaQ30371806
High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populationsQ30496575
Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cellsQ30994095
Untreated aggressive mantle cell lymphoma: results with intensive chemotherapy without stem cell transplant in elderly patientsQ33333989
The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cellsQ33585273
Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivityQ33771413
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Q33835200
Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of originQ33849548
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemiaQ33873337
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.Q33873343
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesQ33893704
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinaseQ34001339
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.Q34026194
Do mantle cell lymphomas have an 'Achilles heel'?Q34090009
Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigenQ34150551
Pathology of B-cell lymphomas: diagnosis and biomarker discoveryQ38345563
Phase II study of copanlisib, a PI3K inhibitor, in relapsed or refractory, indolent or aggressive lymphomaQ38373698
Mantle cell lymphoma: 2015 update on diagnosis, risk-stratification, and clinical managementQ38535489
B-cell receptor signaling in the pathogenesis of lymphoid malignanciesQ38557936
Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 studyQ38670952
Targeting of B-cell receptor signalling in B-cell malignancies.Q38744922
Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesisQ39028931
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphomaQ39040982
Bruton tyrosine kinase is commonly overexpressed in mantle cell lymphoma and its attenuation by Ibrutinib induces apoptosisQ39107651
A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodiesQ40020213
Acquired immune-related and inflammatory conditions and subsequent chronic lymphocytic leukaemiaQ40163057
Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.Q40314484
Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphomaQ40330626
Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell LympQ40696072
Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.Q40716705
Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma NetworkQ40880831
Structures of bacterial immunoglobulin-binding domains and their complexes with immunoglobulinsQ40927379
Clonal selection and learning in the antibody systemQ41002744
Complementarity determining region-independent recognition of a superantigen by B-cell antigen receptors of mantle cell lymphomaQ42384350
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profilingQ42503470
Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 casesQ42610807
Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphomaQ43948770
CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL.Q44099314
Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectinsQ34276522
Antigen receptors on B lymphocytesQ34420640
IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphomaQ34440364
The evolution of adaptive immune systemsQ34497263
Impact of Rituximab (Rituxan) on the Treatment of B-Cell Non-Hodgkin's LymphomaQ34619308
A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL).Q34663617
Respiratory tract infections and subsequent risk of chronic lymphocytic leukemiaQ35642807
Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphomaQ35786734
Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profilingQ35848185
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphomaQ35848973
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapiesQ36083000
Mechanisms of B-cell lymphoma pathogenesisQ36085626
Does DNA repair occur during somatic hypermutation?Q36173864
Molecular pathogenesis of mantle cell lymphomaQ36290246
Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cellsQ36369816
Confounding B-cell defences: lessons from a staphylococcal superantigenQ36488759
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic LeukemiaQ36490049
CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphomaQ36628297
Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signatureQ36629194
The SYK tyrosine kinase: a crucial player in diverse biological functionsQ36662082
Nonstereotyped lymphoma B cell receptors recognize vimentin as a shared autoantigenQ36788328
The cellular origin of mantle cell lymphoma.Q36851684
The 2016 revision of the World Health Organization classification of lymphoid neoplasmsQ36920426
Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidationQ36972595
Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphomaQ37076425
Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical featuresQ37149519
Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureusQ37322841
Common community acquired infections and subsequent risk of chronic lymphocytic leukaemiaQ37421797
Autologous and allogeneic stem cell transplantation: rising therapeutic promise for mantle cell lymphomaQ37534547
Structure and function of immunoglobulinsQ37696721
Pathogenesis of non-Hodgkin's lymphomaQ37863998
Targeting Bruton's tyrosine kinase in B cell malignanciesQ38198490
Staphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes.Q38303556
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.Q38306094
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectblood proteinsQ425056
cell surface receptorQ2476074
mantle cell lymphomaQ268713
globulinsQ321710
membrane proteinQ423042
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)164
P577publication date2017-10-17
P1433published inJournal of Hematology & OncologyQ15724593
P1476titleThe role of B cell antigen receptors in mantle cell lymphoma
P478volume10

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cites work (P2860)
Q58773255Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma
Q89998321Antibody-drug conjugates in clinical trials for lymphoid malignancies and multiple myeloma
Q61797408Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia
Q50350976Potential added value of a RT-qPCR method of SOX 11 expression, in the context of a multidisciplinary diagnostic assessment of B cell malignancies.

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