Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

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Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase is …
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scholarly articleQ13442814

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P356DOI10.1002/CMDC.200600221
P8608Fatcat IDrelease_34jbtmchlnelzoamvjvyeatn5m
P698PubMed publication ID17154430
P5875ResearchGate publication ID6645799

P2093author name stringPeter R Young
Jill M Spoerke
Zhengying Pan
Paul A Sprengeler
Heleen Scheerens
James T Palmer
Brian E Schultz
Douglas A Jeffery
Lee A Honigberg
Rohan V Mendonca
Keana C K Scott
Stacie A Dalrymple
L Chuck Burrill
Michael D Sweeney
Paul G Grothaus
Shyr-Jiann Li
P2860cites workStructural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitorsQ27619043
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemiaQ27634627
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitorQ28368986
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]Q28372191
Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)Q28569704
A small molecule-kinase interaction map for clinical kinase inhibitorsQ29617451
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activityQ30658242
Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genesQ31017238
Tec kinases: modulators of lymphocyte signaling and developmentQ34282327
Irreversible inhibitors of the erbB family of protein tyrosine kinasesQ34792935
Therapeutic strategies for rheumatoid arthritisQ35140855
Features of selective kinase inhibitorsQ36173396
Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagementQ36368492
Structural bioinformatics-based design of selective, irreversible kinase inhibitorsQ40307105
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.Q40457478
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptorQ40951781
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck IQ73022511
Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic eraQ77796116
Structural basis for selective inhibition of Src family kinases by PP1Q78192599
P433issue1
P304page(s)58-61
P577publication date2007-01-01
P1433published inChemMedChemQ2962252
P1476titleDiscovery of selective irreversible inhibitors for Bruton's tyrosine kinase
P478volume2

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cites work (P2860)
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