The K1K2 region of Lys-gingipain of Porphyromonas gingivalis blocks induction of HLA expression by gamma interferon

scientific article published on 16 July 2012

The K1K2 region of Lys-gingipain of Porphyromonas gingivalis blocks induction of HLA expression by gamma interferon is …
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scholarly articleQ13442814

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P356DOI10.1128/IAI.00528-12
P932PMC publication ID3457573
P698PubMed publication ID22802347

P2093author name stringNan Li
Charles A Collyer
Neil Hunter
Peter L Yun
P2860cites workGenetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagAQ77863752
Recognition of the helical cytokine foldQ81300947
Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitisQ94847663
Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalisQ27660251
The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalisQ27671445
Interferon-γ: an overview of signals, mechanisms and functionsQ28207081
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosomeQ28287810
The glycosylation heterogeneity of recombinant human IFN-gammaQ32061575
Use of synthetic peptides to identify an N-terminal epitope on mouse gamma interferon that may be involved in functionQ33554393
Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalisQ33716115
Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatmentQ33752036
Porphyrin-mediated binding to hemoglobin by the HA2 domain of cysteine proteinases (gingipains) and hemagglutinins from the periodontal pathogen Porphyromonas gingivalisQ33992343
Modulation of major histocompatibility complex protein expression by human gamma interferon mediated by cysteine proteinase-adhesin polyproteins of Porphyromonas gingivalisQ34001160
Hydrolysis of interleukin-12 by Porphyromonas gingivalis major cysteine proteinases may affect local gamma interferon accumulation and the Th1 or Th2 T-cell phenotype in periodontitisQ34009005
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalisQ34010067
Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorptionQ34246960
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyproteinQ34317271
Destructive periodontitis lesions are determined by the nature of the lymphocytic response.Q34720552
The role of gingipains in the pathogenesis of periodontal diseaseQ35068830
The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein propertiesQ35292620
Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexesQ35610528
Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal diseaseQ35755276
Gingipains from Porphyromonas gingivalis - Complex domain structures confer diverse functionsQ38182102
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One interferon gamma receptor binds one interferon gamma dimerQ41714787
The gingival tissues: the architecture of periodontal protectionQ41754677
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria?Q42957420
Amino terminus is essential to the structural integrity of recombinant human interferon-gammaQ43859976
Enhancement of Th2 pathways and direct activation of B cells by the gingipains of Porphyromonas gingivalisQ44655260
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinasesQ46086294
Periodontal disease at the biofilm-gingival interfaceQ46864214
Structure of an epitope in an immunodominant region of the interferon-gamma molecule that is involved in receptor interaction.Q52480195
Failure of macrophage activation in destructive periodontal disease.Q54098910
Trypanosoma cruzi-induced decrease in the level of interferon-gamma receptor expression by resting and activated human blood lymphocytesQ58843704
Immune response in mice that lack the interferon-gamma receptorQ62022366
The release of interleukin-1 beta, tumor necrosis factor-alpha and interferon-gamma by cultured peripheral blood mononuclear cells from patients with periodontitisQ68423129
Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient miceQ72158253
Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketingQ73052175
Inhibition of interferon-gamma signaling by Leishmania donovaniQ73556621
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectPorphyromonas gingivalisQ3214147
P304page(s)3733-3741
P577publication date2012-07-16
P1433published inInfection and ImmunityQ6029193
P1476titleThe K1K2 region of Lys-gingipain of Porphyromonas gingivalis blocks induction of HLA expression by gamma interferon
P478volume80

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