A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma

scientific article published on 8 January 2015

A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-14-2820
P932PMC publication ID6607903
P698PubMed publication ID25573383

P50authorBarbara BurtnessQ89693033
P2093author name stringJing Wang
Jill Gilbert
Julie E Bauman
Lori J Wirth
Antonio Jimeno
David Raben
Nabil F Saba
Ranee Mehra
Thomas J Galloway
Alexander D Colevas
Anna W Ma
Ruzanna Atoyan
P2860cites workHuman Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United StatesQ22306233
Improving the efficacy of chemoradiation with targeted agentsQ26850193
Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repairQ26863429
HER2 as a therapeutic target in head and neck squamous cell carcinomaQ27026178
Human papillomavirus and survival of patients with oropharyngeal cancer.Q27851567
Cancer statistics, 2014Q27861018
The mutational landscape of head and neck squamous cell carcinomaQ29614654
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neckQ29619277
Novel insight into mutational landscape of head and neck squamous cell carcinomaQ30441193
Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522.Q34171999
Targeting HER2 in other tumor typesQ34346131
Histone-deacetylase inhibitors: novel drugs for the treatment of cancerQ34743301
Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial.Q35152720
Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neckQ35287729
A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck.Q35743883
Modulation of cellular radiation responses by histone deacetylase inhibitorsQ36389311
Epidermal growth factor receptor biology in head and neck cancerQ36500973
Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinomaQ36617162
Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancerQ37337056
Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease.Q38069662
Novel targets in HPV-negative head and neck cancer: overcoming resistance to EGFR inhibitionQ38118439
Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas.Q38433814
Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin accessQ39518179
CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activityQ39715181
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family membersQ40009294
Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX fociQ40240295
Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumorsQ42704536
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 studyQ43105772
Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.Q44260431
Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition.Q53657859
Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survivalQ83764762
Vorinostat as a radiosensitizer for brain metastasis: a phase I clinical trialQ87674625
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectchemoradiotherapyQ5090613
P304page(s)1566-1573
P577publication date2015-01-08
P1433published inClinical Cancer ResearchQ332253
P1476titleA Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma
P478volume21

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cites work (P2860)
Q36978557CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy
Q38637354Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers
Q28067666Epigenetic polypharmacology: from combination therapy to multitargeted drugs
Q64119667GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer
Q38947405HDACs and HDAC Inhibitors in Cancer Development and Therapy
Q93080888Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors
Q102211000Moving targets in drug discovery
Q38739347Multitarget Drugs: an Epigenetic Epiphany.
Q47243959SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis
Q38253835Small molecule tyrosine kinase inhibitors of ErbB2/HER2/Neu in the treatment of aggressive breast cancer.
Q96341682Strategies for testing intervention matching schemes in cancer
Q89169966Targeting Epigenetics in Cancer

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