Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair

scientific article

Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1043470291
P356DOI10.1038/BJC.2013.21
P3181OpenCitations bibliographic resource ID1103206
P932PMC publication ID3590661
P698PubMed publication ID23361058
P5875ResearchGate publication ID235382410

P50authorAnne E KiltieQ39896443
P2093author name stringF C Hamdy
M Kerr
N L Sharma
B Groselj
P2860cites workHDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombinationQ24670026
Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factorQ28474504
Epigenetics in cancerQ29617139
Modulation of radiation response by histone deacetylase inhibitionQ33214371
Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgeryQ82996604
Epigenetic therapy and cisplatin chemoradiation in FIGO stage IIIB cervical cancerQ33392099
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapyQ33778769
HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cellsQ34062580
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.Q34093052
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaksQ34432615
Targeting abnormal DNA double strand break repair in cancerQ34457557
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.Q34488424
Histone deacetylases 9 and 10 are required for homologous recombinationQ34624058
Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapyQ34915905
Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinicQ35038016
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapyQ35975127
Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivoQ37244481
Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?Q37252722
The role of histone deacetylases (HDACs) in human cancerQ37453782
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relaxQ37805244
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreographyQ38022419
The emerging role of histone deacetylase (HDAC) inhibitors in urological cancersQ38095611
Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia.Q38327984
Adamantanyl-histone deacetylase inhibitor H6CAHA exhibits favorable pharmacokinetics and augments prostate cancer radiation sensitivityQ39601063
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joiningQ39662092
Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibitionQ39677848
Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiationQ39767757
Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cellsQ39875544
Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines.Q39978688
Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancerQ40200801
Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX fociQ40240295
Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activityQ40401113
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 studyQ43105772
Influence of valproic acid on outcome of high-grade gliomas in children.Q46408823
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDNA repairQ210538
neoplasmQ1216998
radiosensitizerQ2126468
histone deacetylase inhibitorsQ3569101
DNA damageQ5205747
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)748-754
P577publication date2013-01-29
2013-03-05
P1433published inBritish Journal of CancerQ326309
P1476titleHistone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair
P478volume108

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cites work (P2860)
Q42702942A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma
Q91642406A three layered histone epigenetics in breast cancer metastasis
Q64099911Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70
Q98564346Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation
Q35108007Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy
Q53681442Bromodomain proteins: repairing DNA damage within chromatin.
Q38187679Cancer biomarker discovery: current status and future perspectives.
Q48596058Chemotherapy is getting 'smarter'.
Q41592921Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation
Q33907067Chromatin-regulating proteins as targets for cancer therapy
Q41872120Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage
Q52590685Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi.
Q31133958Combination therapy with the histone deacetylase inhibitor LBH589 and radiation is an effective regimen for prostate cancer cells.
Q55359395Combined alkylation and histone deacetylase inhibition with EDO-S101 has significant therapeutic activity against brain tumors in preclinical models.
Q91588484Comparison of Radiosensitization by HDAC Inhibitors CUDC-101 and SAHA in Pancreatic Cancer Cells
Q48308220Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors.
Q35176178DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study
Q36038071Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair
Q36553263Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer
Q42873813Effect of trichostatin a on SGC-7901 gastric cancer cells
Q37658507Effects of Valproic Acid on Radiation-Induced Chromosomal Aberrations in Human Lymphocytes
Q92405274Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells
Q38970754Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus
Q92259153Focus-ING on DNA Integrity: Implication of ING Proteins in Cell Cycle Regulation and DNA Repair Modulation
Q92626235Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy
Q50317222HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
Q37388728Histone deacetylase inhibitor, valproic acid, radiosensitizes the C6 glioma cell line in vitro
Q37223734Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin
Q34109472Histones: Controlling Tumor Signaling Circuitry
Q38817005How do tumor cells respond to HDAC inhibition?
Q36946725Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia
Q38748006Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Q60028152Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
Q99238268Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting
Q33584050Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy
Q64061318Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy
Q64065358Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [F]TFAHA
Q40084337Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways
Q34474232Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage
Q37676851Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
Q39035998Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines
Q38761174Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?
Q47908872Radiosensitisation in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity
Q39112866Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression.
Q35209439Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays
Q41874822Rapid and transient protein acetylation changes in response to DNA damage
Q38989816Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide
Q35018496Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.
Q46038047Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53.
Q34413200Systematic analysis of time-series gene expression data on tumor cell-selective apoptotic responses to HDAC inhibitors
Q27023204Targeting DNA damage response in cancer therapy
Q50649482Targeting HDAC3, a new partner protein of AKT in the reversal of chemoresistance in acute myeloid leukemia via DNA damage response.
Q35821728Targeting Histone Deacetylases in Diseases: Where Are We?
Q50926267Targeting histone deacetylase 4/ubiquitin-conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in mice.
Q33755207The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats
Q51746838The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.
Q47987478The influence of ketogenic therapy on the 5 R's of radiobiology.
Q38877902The molecular hallmarks of epigenetic control
Q39249171The rs7003908 (T>G) polymorphism in the XRCC7 gene and the risk of cancers
Q41347312Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat.
Q47429195Trek1 contributes to maintaining nasal epithelial barrier integrity
Q46265462Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation
Q64389971Valproic acid causes radiosensitivity of breast cancer cells disrupting the DNA repair pathway
Q36544286Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells
Q38826037Valproic acid modulates radiation-enhanced matrix metalloproteinase activity and invasion of breast cancer cells.

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