Runx2 Deletion in Smooth muscle Cells Inhibits Vascular Osteochondrogenesis and Calcification but not Atherosclerotic Lesion Formation.

scientific article published on 26 September 2016

Runx2 Deletion in Smooth muscle Cells Inhibits Vascular Osteochondrogenesis and Calcification but not Atherosclerotic Lesion Formation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/CVR/CVW205
P932PMC publication ID5079276
P698PubMed publication ID27671804

P50authorChenphop SawangmakeQ85236563
P2093author name stringCecilia M Giachelli
Shunsuke Yamada
Mei Y Speer
Ngoc B Nguyen
Mu-En Lin
Mary C Wallingford
Theodore M Chen
Jaimei Zhang
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Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesisQ33952717
RUNX3 regulates intercellular adhesion molecule 3 (ICAM-3) expression during macrophage differentiation and monocyte extravasationQ34221376
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Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis.Q34790965
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumQ35106164
Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotypeQ35130704
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesisQ35146679
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Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in MiceQ35792795
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Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiationQ35949809
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.Q36678487
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Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.Q36917940
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Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytesQ37228025
Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteriesQ37276028
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
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BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell linesQ38305733
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.Q40251686
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signalingQ40540364
The receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) is a new chemotactic factor for human monocytesQ40637314
Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping studyQ42172818
Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant miceQ42405231
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Cartilaginous metaplasia in calcified diabetic peripheral vascular disease: Morphologic evidence of enchondral ossificationQ44431335
Runx2 deficiency in chondrocytes causes adipogenic changes in vitroQ44711017
Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis.Q50479986
A comparison of the Framingham risk index, coronary artery calcification, and culprit plaque morphology in sudden cardiac death.Q52080807
Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification.Q52173037
Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels.Q54784940
Arterial Calcification and Not Lumen Stenosis Is Highly Correlated With Atherosclerotic Plaque Burden in Humans: A Histologic Study of 723 Coronary Artery Segments Using Nondecalcifying MethodologyQ58492269
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Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative studyQ71730400
Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcificationQ73075489
P433issue2
P921main subjectatherosclerosisQ12252367
P304page(s)606-616
P577publication date2016-11-01
P1433published inCardiovascular ResearchQ4642329
P1476titleRunx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation
P478volume112

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