Co-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis

scientific article published on April 2006

Co-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V12.I13.1985
P932PMC publication ID4087673
P698PubMed publication ID16610045
P5875ResearchGate publication ID298738154

P2093author name stringGeorge Perides
Gijs J D van Acker
Michael L Steer
P2860cites workPhosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitisQ28363504
Intracellular Aspects of the Process of Protein SynthesisQ29615237
Regulated secretion of conventional lysosomesQ33960468
Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitisQ34578778
Processing and activation of lysosomal proteinasesQ35055169
Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalizationQ35816048
Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstructionQ35819400
Trafficking of lysosomal enzymes in normal and disease statesQ38351553
Pancreatitis. The role of lysosomesQ40187253
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
Lysosomal enzymes in pure pancreatic juice from normal healthy volunteers and chronic alcoholicsQ41678950
The effect of chloroquine administration on two experimental models of acute pancreatitis.Q41937542
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severityQ44104053
Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitisQ44929893
Protection against acute pancreatitis by activation of protease-activated receptor-2.Q45086307
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Frank Brooks memorial Lecture: The early intraacinar cell events which occur during acute pancreatitisQ48585468
Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells.Q52479559
Regulated secretion of mature cathepsin B from rat exocrine pancreatic cellsQ67875610
Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1Q67988505
Localization of lysosomal and digestive enzymes in cytoplasmic vacuoles in caerulein-pancreatitisQ68826236
In vivo rat pancreatic acinar cell function during supramaximal stimulation with caeruleinQ68951595
Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulationQ69414353
Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitisQ69808490
Protective effect of a cephalosporin, Shiomarin, plus a new potent protease inhibitor, E3123, on rat taurocholate-induced pancreatitisQ70576364
Assay of trypsinogen activation in the cat experimental model of acute pancreatitisQ70628189
Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitisQ71345530
Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitisQ71404575
Influence of ductal pressure and infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreasQ71890565
Lysosomal enzymes and pancreatitisQ71890589
Pancreatic duct obstruction triggers acute necrotizing pancreatitis in the opossumQ72071414
Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in ratsQ74831729
Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitisQ77551309
Cytokine suppressive agent improves survival rate in rats with acute pancreatitis of closed duodenal loopQ77933342
The activation of trypsinogen by cathepsin BQ79317421
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)1985-1990
P577publication date2006-04-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleCo-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis
P478volume12

Reverse relations

cites work (P2860)
Q30479173Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells
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Q41230243Cathepsin B: Basis Sequence: Mouse
Q46439176Clinical efficacy of gabexate mesilate for acute pancreatitis in children
Q37638308Effects of diazoxide in experimental acute necrotizing pancreatitis.
Q93000610Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B
Q35619181Heat shock proteins and autophagy in rats with cerulein-induced acute pancreatitis
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Q37203732Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells
Q27004531Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities
Q54961165Molecular architecture of mouse and human pancreatic zymogen granules: protein components and their copy numbers.
Q54518014P-selectin mediates neutrophil rolling and recruitment in acute pancreatitis.
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Q36892524Proteoglycanomics: tools to unravel the biological function of glycosaminoglycans.
Q37797839Specialized roles for cysteine cathepsins in health and disease.
Q42952122Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini
Q46986154The apoptosis of peripheral blood lymphocytes promoted by hyperbaric oxygen treatment contributes to attenuate the severity of early stage acute pancreatitis in rats
Q35001139The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells
Q37445949Therapeutically targeting protein-glycan interactions
Q38246368Trypsin isozymes in the lobster Panulirus argus (Latreille, 1804): from molecules to physiology

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