Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation

scientific article published on 22 September 2016

Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.116.308344
P932PMC publication ID5102271
P698PubMed publication ID27659097

P2093author name stringBysani Chandrasekar
Jianbo Wu
Mao Luo
Yan Ji
Neha Goyal
William P Fay
Tammy L Strawn
Zhen Weng
Philip Fish
Samantha P Myears
P2860cites workInhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in miceQ24310475
The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectinQ24310652
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migrationQ24546040
TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesionsQ28201964
Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1Q28345650
Colocalization of thrombin, PAI-1, and vitronectin in the atherosclerotic vessel wall: A potential regulatory mechanism of thrombin activity by PAI-1/vitronectin complexesQ28376780
Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosisQ28383719
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PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.Q33627219
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Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterizationQ33979344
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Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpinQ34333539
Localization of vitronectin in the normal and atherosclerotic human vessel wallQ34740237
A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavageQ35181410
Mouse model of venous bypass graft arteriosclerosisQ35753478
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?Q36237406
Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteriesQ37131350
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studiesQ37216064
Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescenceQ37600695
Vascular smooth muscle cell proliferation in restenosisQ37843083
Plasminogen activator inhibitor-1 inhibitors: a patent review (2006-present).Q38092174
Impaired arterial neointima formation in mice with disruption of the plasminogen geneQ39776706
The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.Q40582221
Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteriesQ40724602
Multifaceted role of plasminogen activator inhibitor-1 in regulating early remodeling of vein bypass graftsQ42128982
Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matricesQ42425209
Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone miceQ43653265
Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.Q43909364
Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formationQ43939747
Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathwaysQ44728938
Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1.Q44850328
Plasminogen activator inhibitor type 1 increases neointima formation in balloon-injured rat carotid arteriesQ45880462
Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis.Q46420379
Photochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimal thickening.Q50523399
Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3.Q51519556
A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.Q53117289
Vitronectin inhibits plasminogen activator inhibitor-1-induced signalling and chemotaxis by blocking plasminogen activator inhibitor-1 binding to the low-density lipoprotein receptor-related protein.Q53460186
The effect of plasminogen activator inhibitor type 1 on apoptosis.Q53519372
Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1.Q53622123
Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutationQ55670530
The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic SyndromeQ57423553
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarctionQ69973450
Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosisQ70343112
Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosisQ71675475
PAI-1, obesity, insulin resistance and risk of cardiovascular eventsQ73447611
Plasminogen activator inhibitor-1 in neointima of vein grafts: its role in reduced fibrinolytic potential and graft failureQ73762705
Remodeling with neointima formation in the mouse carotid artery after cessation of blood flowQ73832982
Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injuryQ73964036
Plasminogen activator inhibitor 1 and vitronectin protect against stenosis in a murine carotid artery ligation modelQ78664253
Enhanced thrombosis in atherosclerosis-prone mice is associated with increased arterial expression of plasminogen activator inhibitor-1Q79086796
Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesisQ79160721
Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitorQ79717738
The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injuryQ81711993
Inhibition of PAI-1 Via PAI-039 Improves Dermal Wound Closure in DiabetesQ86895066
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2167-2175
P577publication date2016-09-22
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titlePharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation
P478volume36

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cites work (P2860)
Q47245967Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
Q92056401Effects of 17β-Estradiol on the Plasminogen Activator System in Vascular Smooth Muscle Cells Treated with Lysophophatidylcholine
Q88938326Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation
Q47657969Plasminogen activator inhibitor-1 regulates the vascular expression of vitronectin
Q90279580Protease Activity in Vascular Disease
Q57818443Reporting Sex and Sex Differences in Preclinical Studies
Q88792493Thrombotic Regulation From the Endothelial Cell Perspectives

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