An improved rapid mixing device for time-resolved electrospray mass spectrometry measurements

scientific article published on 16 June 2014

An improved rapid mixing device for time-resolved electrospray mass spectrometry measurements is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/OPEN.201402002
P932PMC publication ID4101726
P698PubMed publication ID25050229
P5875ResearchGate publication ID264641800

P50authorAnn-Kathrin StarkQ125348845
Michal SharonQ21264412
P2093author name stringDerek J Wilson
Nicholas Zinck
P2860cites workCo-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometryQ44853349
Kinetic unfolding mechanism of the inducible nitric oxide synthase oxygenase domain determined by time-resolved electrospray mass spectrometry.Q45264091
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Conserved folding pathways of alpha-lactalbumin and lysozyme revealed by kinetic CD, fluorescence, NMR, and interrupted refolding experiments.Q45910520
A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometryQ47304818
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Analysis of disordered proteins using a simple apparatus for millisecond quench-flow H/D exchange.Q51068309
A capillary mixer with adjustable reaction chamber volume for millisecond time-resolved studies by electrospray mass spectrometry.Q51274842
Protein-protein binding affinities in solution determined by electrospray mass spectrometry.Q51581306
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Acid-induced unfolding of cytochrome c at different methanol concentrations: electrospray ionization mass spectrometry specifically monitors changes in the tertiary structureQ73745091
From small-molecule reactions to protein folding: studying biochemical kinetics by stopped-flow electrospray mass spectrometryQ73800244
Stopped-flow electrospray ionization mass spectrometry: a new method for studying chemical reaction kinetics in solutionQ73821516
Detection and identification of transient enzyme intermediates using rapid mixing, pulsed-flow electrospray mass spectrometryQ73940430
Hydroquinone as a buffer additive for suppression of bubbles formed by electrochemical oxidation of the CE buffer at the outlet electrode in capillary electrophoresis/electrospray ionization-mass spectrometryQ77376904
Unfolding of proteins monitored by electrospray ionization mass spectrometry: a comparison of positive and negative ion modesQ77623054
Studying chaperone-proteases using a real-time approach based on FRETQ84206442
Quantifying protein-ligand binding constants using electrospray ionization mass spectrometry: a systematic binding affinity study of a series of hydrophobically modified trypsin inhibitorsQ84743382
Conformer selection and intensified dynamics during catalytic turnover in chymotrypsinQ84906286
Assembly of hemoglobin from denatured monomeric subunits: heme ligation effects and off-pathway intermediates studied by electrospray mass spectrometryQ86151634
Measuring kinetic isotope effects in enzyme reactions using time-resolved electrospray mass spectrometryQ86276563
Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry.Q24810397
Hydrogen exchange mass spectrometry for studying protein structure and dynamicsQ28301471
Folding kinetics of the S100A11 protein dimer studied by time-resolved electrospray mass spectrometry and pulsed hydrogen-deuterium exchange.Q30353148
Temporal development of protein structure during S100A11 folding and dimerization probed by oxidative labeling and mass spectrometry.Q30402108
Integrating mass spectrometry of intact protein complexes into structural proteomicsQ30417001
Monitoring enzyme catalysis with mass spectrometry.Q30864676
Combining ultrarapid mixing with photochemical oxidation to probe protein foldingQ31115411
Control of electrochemical reactions at the capillary electrophoresis outlet/electrospray emitter electrode under CE/ESI-MS through the application of redox buffersQ31995905
Electrospray ionization mass spectrometry as a method for studying the high-pressure denaturation of proteinsQ33442202
Electrochemical aspects of electrospray and laser desorption/ionization for mass spectrometryQ33634340
Kinetic folding mechanism of an integral membrane protein examined by pulsed oxidative labeling and mass spectrometryQ33899639
Time-resolved mass spectrometry for monitoring millisecond time-scale solution-phase processesQ34277795
Submillisecond protein folding events monitored by rapid mixing and mass spectrometry-based oxidative labeling.Q34809660
Studies of biomolecular conformations and conformational dynamics by mass spectrometryQ34811742
Mass spectrometric approaches using electrospray ionization charge states and hydrogen-deuterium exchange for determining protein structures and their conformational changesQ35587004
Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic coreQ35691003
Circular dichroism analysis for protein-protein interactionsQ35738236
Mass spectrometric approaches for the investigation of dynamic processes in condensed phaseQ35897309
Time-resolved fluorescence microscopyQ35992536
Cytochrome c folds through a smooth funnelQ36281933
Probing early events in ferrous cytochrome c folding with time-resolved natural and magnetic circular dichroism spectroscopiesQ37439424
Capturing protein structural kinetics by mass spectrometryQ37872627
Native ion mobility-mass spectrometry and related methods in structural biologyQ38068027
Conformational changes in chemically modified Escherichia coli thioredoxin monitored by H/D exchange and electrospray ionization mass spectrometry.Q38269927
Influence of solution and gas phase processes on protein-carbohydrate binding affinities determined by nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometryQ38346221
Real-time monitoring of protein complexes reveals their quaternary organization and dynamics.Q38457384
Characterizing short-lived protein folding intermediates by top-down hydrogen exchange mass spectrometryQ39836702
Do ionic charges in ESI MS provide useful information on macromolecular structure?Q40074233
Mechanistic studies on enzymatic reactions by electrospray ionization MS using a capillary mixer with adjustable reaction chamber volume for time-resolved measurements.Q40513804
T-wave ion mobility-mass spectrometry: basic experimental procedures for protein complex analysisQ42854844
Interrupted hydrogen/deuterium exchange reveals the stable core of the remarkably helical molten globule of alpha-beta parallel protein flavodoxinQ42912766
Electrochemically induced pH changes resulting in protein unfolding in the ion source of an electrospray mass spectrometerQ43780171
P433issue3
P304page(s)109-114
P577publication date2014-06-16
P1433published inChemistryOpenQ19277289
P1476titleAn improved rapid mixing device for time-resolved electrospray mass spectrometry measurements
P478volume3

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cites work (P2860)
Q49946759In-Source Reduction of Disulfide-Bonded Peptides Monitored by Ion Mobility Mass Spectrometry.
Q35001286Investigating protein folding and unfolding in electrospray nanodrops upon rapid mixing using theta-glass emitters
Q36840082Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform
Q39106450Rapid capillary mixing experiments for the analysis of hydrophobic membrane complexes directly from aqueous lipid bilayer solutions.

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