A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution

scientific article published on 25 November 2010

A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C0AN00643B
P932PMC publication ID3115584
P698PubMed publication ID21107456
P5875ResearchGate publication ID49635610

P50authorNicolas A StewartQ42758600
P2093author name stringThomas P Conrads
Robert A Branch
Shama C Buch
P2860cites workCombined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".Q44637323
Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approachQ45278849
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".Q51373538
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.Q51432740
Metabolism of drugs and carcinogens by human liver enzymesQ68717160
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study designQ69615072
High-performance liquid chromatographic determination of urinary 4'-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humansQ71722771
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymesQ73846452
Liver disease selectively modulates cytochrome P450--mediated metabolismQ80212249
Validation of incorporating flurbiprofen into the Pittsburgh cocktailQ80212255
In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten modelQ31520211
Summary of information on human CYP enzymes: human P450 metabolism dataQ32103802
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approachQ34418061
Cytochromes P450 in the bioactivation of chemicalsQ35972701
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approachQ36720920
Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1(-/-) miceQ36990035
Cytochrome P450-activated prodrugs: targeted drug delivery.Q37294258
Molecular modeling of cytochrome P450 and drug metabolismQ37743544
A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humansQ37946157
P450 genes: structure, evolution, and regulationQ39664988
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclatureQ40484461
The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.Q44481060
P4510describes a project that usesstable isotopeQ878130
P433issue3
P921main subjectstable isotopeQ878130
P304page(s)605-612
P577publication date2010-11-25
P1433published inAnalystQ969812
P1476titleA UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution
P478volume136

Reverse relations

cites work (P2860)
Q92193026Analytical Methods for Mass Spectrometry-Based Metabolomics Studies
Q37034724Effect of Repeated Wuniu Early Tea Administration on the CYP450 Activity Using a Cocktail Method
Q57157647Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis
Q47782012Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats
Q38769103Emerging applications of metabolomics in drug discovery and precision medicine
Q39508644Quantifying four-probe metabolites in a single UPLC-MS/MS run to explore the effects of cooked rhubarb on cytochrome P450 isozymes
Q40643491Rapid and accurate liquid chromatography and tandem mass spectrometry method for the simultaneous quantification of ten metabolic reactions catalyzed by hepatic cytochrome P450 enzymes
Q51431632Rapid and on-site analysis of illegal drugs on the nano-microscale using a deep ultraviolet-visible reflected optical fiber sensor.
Q41737190Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers.

Search more.