| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/(SICI)1097-0231(19991215)13:23<2305::AID-RCM790>3.0.CO;2-G |
| P698 | PubMed publication ID | 10567928 |
| P2093 | author name string | Palmer J | |
| Scott RJ | |||
| Lewis IA | |||
| Pleasance S | |||
| P2860 | cites work | The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure | Q33486574 |
| A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system | Q33487011 | ||
| In vivo pharmacokinetic screening in cassette dosing experiments; the use of on-line Pprospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery | Q33487840 | ||
| A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans | Q37946157 | ||
| N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity | Q42000770 | ||
| The contribution of N-hydroxylation and acetylation to dapsone pharmacokinetics in normal subjects | Q44986835 | ||
| Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism | Q70670623 | ||
| Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection | Q71791319 | ||
| Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo* | Q71809403 | ||
| Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography | Q71910987 | ||
| Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450 | Q73402015 | ||
| Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes | Q73846452 | ||
| Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates | Q74370415 | ||
| Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential | Q74608267 | ||
| Determination of the glucocorticoid fluticasone propionate in plasma by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry | Q77638945 | ||
| P433 | issue | 23 | |
| P921 | main subject | automation | Q184199 |
| liquid chromatography-tandem mass spectrometry | Q117788892 | ||
| P304 | page(s) | 2305-2319 | |
| P577 | publication date | 1999-01-01 | |
| P1433 | published in | Rapid Communications in Mass Spectrometry | Q3419582 |
| P1476 | title | Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry. | |
| P478 | volume | 13 |
| Q35640730 | "Cocktail" approaches and strategies in drug development: valuable tool or flawed science? |
| Q42758567 | A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution |
| Q42284131 | A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study |
| Q44963267 | Alosetron repeat dose pharmacokinetics, effects on enzyme activities, and influence of demographic factors |
| Q30662377 | An intelligent data acquisition system for simultaneous screening of microsomal stability and metabolite profiling by liquid chromatography/mass spectrometry |
| Q28365904 | An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A) |
| Q31038437 | Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries |
| Q36720920 | Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach |
| Q36855961 | Bioanalysis in drug discovery and development |
| Q42063808 | Buspirone, fexofenadine, and omeprazole: quantification of probe drugs and their metabolites in human plasma |
| Q35579550 | Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism. |
| Q48234146 | Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping |
| Q33466235 | Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening |
| Q58267878 | Determination of Chlorzoxazone in Rat Plasma by LC-ESI-MS/MS and Its Application to a Pharmacokinetic Study |
| Q46538644 | Determination of caffeine and its metabolites in urine by capillary electrophoresis-mass spectrometry |
| Q50069978 | Disposition of bromodichloromethane in humans following oral and dermal exposure |
| Q43109156 | Drug-induced liver injury: is it somehow foreseeable? |
| Q52860025 | Effect of Omeprazole and Dextromethorphan on the Urinary Metabolic Ratio of Flurbiprofen. |
| Q57131458 | Enantioselectivity of debrisoquine 4-hydroxylation in Brazilian Caucasian hypertensive patients phenotyped as extensive metabolizers |
| Q36381336 | Exogenous and endogenous determinants of blood trihalomethane levels after showering |
| Q44437668 | Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry |
| Q33422532 | High-throughput analysis of everolimus (RAD001) and cyclosporin A (CsA) in whole blood by liquid chromatography/mass spectrometry using a semi-automated 96-well solid-phase extraction system |
| Q32079778 | High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment |
| Q43602056 | High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. |
| Q74229453 | High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and |
| Q43620137 | High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy: III. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2C19 inhibition evaluation |
| Q73025601 | High-throughput cytochrome P450 inhibition screening via cassette probe-dosing strategy. IV. Validation of a direct injection on-line guard cartridge extraction/tandem mass spectrometry method for simultaneous CYP3A4, 2D6 and 2E1 inhibition assessme |
| Q44356453 | In vitro ADME profiling using high-throughput rapidfire mass spectrometry: cytochrome p450 inhibition and metabolic stability assays |
| Q46981888 | Investigation of sarizotan's impact on the pharmacokinetics of probe drugs for major cytochrome P450 isoenzymes: a combined cocktail trial |
| Q46922851 | Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin |
| Q39508644 | Quantifying four-probe metabolites in a single UPLC-MS/MS run to explore the effects of cooked rhubarb on cytochrome P450 isozymes |
| Q34378944 | Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review |
| Q44194942 | Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry |
| Q35541824 | Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats. |
| Q34147287 | Solid-phase trapping of solutes for further chromatographic or electrophoretic analysis |
| Q35049310 | Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies. |
| Q86705072 | The basel cocktail for simultaneous phenotyping of human cytochrome P450 isoforms in plasma, saliva and dried blood spots |
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