Concerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair

scientific article published on 4 July 2014

Concerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2014.06.013
P932PMC publication ID4134327
P698PubMed publication ID25001286
P5875ResearchGate publication ID263739340

P50authorGunnar SchottaQ42770525
Creighton TuzonQ77298514
P2093author name stringJudd C Rice
Kyoko Yokomori
Shumin Wu
Lauren M Congdon
Xiaodong Kong
Tanya Spektor
P2860cites workThe N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptorQ39791268
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progressionQ42376622
I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaksQ47564796
PR-Set7 establishes a repressive trans-tail histone code that regulates differentiationQ24312030
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatinQ24561636
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repairQ24669691
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaksQ27337186
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombinationQ27676128
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferasesQ27679986
Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2Q27688088
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouseQ28289637
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiationQ28302907
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sitesQ28304648
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatinQ28647369
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaksQ29465538
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin markQ29465773
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damageQ29614528
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationQ30430339
Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cellsQ30487741
Limiting the persistence of a chromosome break diminishes its mutagenic potentialQ33510904
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damageQ33733896
Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cellsQ33774945
CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S PhaseQ34215301
Double-strand break repair: 53BP1 comes into focusQ34391068
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.Q35125130
Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damageQ35164644
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programmingQ35569571
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycleQ36421082
Preferential dimethylation of histone H4 lysine 20 by Suv4-20Q36585568
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse developmentQ37145387
Identification and characterization of posttranslational modification-specific binding proteins in vivo by mammalian tethered catalysisQ37329561
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repairQ39208600
Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stabilityQ39680313
PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repressionQ39698399
P433issue2
P304page(s)430-438
P577publication date2014-07-04
P1433published inCell ReportsQ5058165
P1476titleConcerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair
P478volume8

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