Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes

scientific article published on 19 August 2006

Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00424-006-0118-X
P698PubMed publication ID16924534

P50authorMònica BullóQ47392947
P2093author name stringBohan Wang
Henning Sievert
Paul Trayhurn
Muhammad R Peeraully
P2860cites workNovel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectinQ22010955
Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissuesQ40667304
15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processesQ40757735
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytesQ42805075
PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectinQ42813848
Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2.Q42818031
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytesQ42819615
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinQ42826174
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone.Q42834547
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db miceQ43718034
Comparison of PGE2, prostacyclin and leptin release by human adipocytes versus explants of adipose tissue in primary cultureQ44240175
Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte culturesQ44814173
Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibitionQ44934471
Human alveolar macrophage arachidonic acid metabolismQ46104862
Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazoneQ46620643
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.Q52895402
Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha.Q54663382
Chemokines control fat accumulation and leptin secretion by cultured human adipocytesQ57076426
Molecular mechanisms of insulin resistance and the role of the adipocyteQ73318407
Tumour necrosis factor-alpha exerts dual effects on human adipose leptin synthesis and releaseQ73476926
Significance of chemokines and activated platelets in patients with diabetesQ74261220
Adipose tissue, insulin action and vascular disease: inflammatory signalsQ75220940
Inflammatory pathways and insulin actionQ75220950
Differential expression of prostaglandin receptor mRNAs during adipose cell differentiationQ78238287
Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alphaQ81053425
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathwayQ24290228
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiationQ24553023
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceQ28131660
Expression and Molecular Pharmacology of the Mouse CRTH2 ReceptorQ28195805
Enhanced release of prostaglandin D2 during re-incubation of RAW 264.7 macrophage-like cells after treatment of both lipopolysaccharide and non-steroidal anti-inflammatory drugsQ28208763
Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonistQ28379508
The adipocyte-secreted protein Acrp30 enhances hepatic insulin actionQ28505765
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Arachidonic acid metabolites of the lipoxygenase as well as the cyclooxygenase pathway may be involved in regulating preadipocyte differentiationQ28566813
NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokinesQ28594619
Cyclopentenone prostaglandins: new insights on biological activities and cellular targetsQ28619819
Regulation of leptin release and lipolysis by PGE2 in rat adipose tissueQ31522617
Leptin--much more than a satiety signalQ34001417
Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balanceQ34039596
Regulation of leptin production: sympathetic nervous system interactions.Q34235173
Transient increase in obese gene expression after food intake or insulin administrationQ34296141
Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulationQ34348569
Adipokines: inflammation and the pleiotropic role of white adipose tissueQ34356530
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ.Q34420472
Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectinQ34493770
Monocyte chemoattractant protein 1 in obesity and insulin resistanceQ35163496
Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosisQ35204725
Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgammaQ35919761
Signalling role of adipose tissue: adipokines and inflammation in obesityQ36295332
Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexiaQ36376685
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamstersQ37354703
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytesQ37555511
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gammaQ38354039
Expression of ob gene in adipose cells. Regulation by insulinQ38361910
Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages.Q40459181
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
P304page(s)177-187
P577publication date2006-08-19
P1433published inPfluegers ArchivQ1091689
P1476titleProstaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes
P478volume453

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cites work (P2860)
Q28750061Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice
Q37072789Down-regulation of nerve growth factor expression in the bladder by antisense oligonucleotides as new treatment for overactive bladder
Q57300145Leptin Elicits LTC Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD Receptors
Q42776506Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway
Q99578963Ramatroban as a Novel Immunotherapy for COVID-19
Q42819259Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes.
Q24315816Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue
Q36979196Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations.
Q36174974The inflammation highway: metabolism accelerates inflammatory traffic in obesity

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