Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System

scientific article published on 16 June 2011

Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/ECAM/NEP083
P932PMC publication ID3136435
P698PubMed publication ID19628662
P5875ResearchGate publication ID26691949

P2093author name stringNaoual Boujedaini
Ayikoe Guy Mensah-Nyagan
Christine Patte-Mensah
Christine Venard
P2860cites workCharacterization of brain neurons that express enzymes mediating neurosteroid biosynthesisQ24676534
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Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cordQ28569789
Neurogenic pain and steroid synthesis in the spinal cordQ28580830
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Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in ratsQ46939757
The induction of pain: an integrative reviewQ48284194
Mechanisms of modulation of pregnanolone on glycinergic response in cultured spinal dorsal horn neurons of rat.Q48685583
Allopregnanolone (THP) mediates anesthetic effects of progesterone in rat brainQ49092473
The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.Q51428663
Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA ReceptorsQ51610341
Nonneuronal localization for steroid converting enzyme: 3 alpha-hydroxysteroid oxidoreductase in olfactory tubercle of rat brain.Q51752812
HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae.Q64925653
Cytotoxic steroids of Gelsemium sempervirensQ69402140
14 beta-Hydroxygelsedine, a new oxindole alkaloid from Gelsemium sempervirensQ69806192
Morphine-6-glucuronide: potency and safety compared with morphineQ94704296
Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociceptionQ33216935
Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteinsQ33242184
Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.Q33537213
The glycinergic inhibitory synapse.Q34298993
Molecular structure and function of the glycine receptor chloride channelQ34350629
Stress and neuroactive steroidsQ34400471
The role of the amygdala in fear and anxietyQ34401070
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sitesQ34582058
Descending control of painQ34659433
Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in miceQ34713732
The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injuryQ34753261
In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetineQ34763151
Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine.Q34764683
Tolerability of modern antidepressantsQ34780181
Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significanceQ35254149
Regional dissociations within the hippocampus--memory and anxiety.Q35822452
Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant actionQ36297266
Glycinergic transmissionQ36522916
Neurosteroids, neuroactive steroids, and symptoms of affective disordersQ36589905
Tiagabine in anxiety disordersQ36613901
Peripheral neuropathy and neurosteroid formation in the central nervous systemQ36873009
Opioid complications and side effects.Q37149936
Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cellsQ40009529
Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress conditionQ40025705
Evidence that 3 alpha-hydroxy-5 alpha-pregnan-20-one is the metabolite responsible for anesthesia induced by 5 alpha-pregnanedione in the mouseQ41127021
Development and regeneration of the nervous system: a role for neurosteroidsQ41138559
HPLC quantification of uncarine D and the anti-plasmodial activity of alkaloids from leaves of Mitragyna inermis (Willd.) O. KuntzeQ41912751
Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord.Q42517942
Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductaseQ42622787
Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus.Q42631943
Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous ratsQ42674934
Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed miceQ43557187
Subunit-specific modulation of glycine receptors by neurosteroidsQ43719547
Evidence for strychnine-sensitive glycine receptors in human amygdala.Q44552458
New Oxindole Alkaloids and Iridoid from Carolina jasmine (Gelsemium sempervirens AIT. f.)Q44603071
Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizuresQ44860916
Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice.Q44861678
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanoloneQ44945736
Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks.Q45037289
Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in ratsQ45272355
The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brainQ46876129
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectstrychnineQ194406
Gelsemium sempervirensQ978130
P304page(s)407617
P577publication date2011-06-16
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleComparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System
P478volume2011

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cites work (P2860)
Q60731226Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms
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Q50082001Experimental neuropharmacology of Gelsemium sempervirens: Recent advances and debated issues
Q34410758Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens.
Q21090472Gelsemine and Gelsemium sempervirens L. Extracts in Animal Behavioral Test: Comments and Related Biases
Q38369284Gelsemium sempervirens and Animal Behavioral Models
Q35930094Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain
Q39010909Koumine exhibits anxiolytic properties without inducing adverse neurological effects on functional observation battery, open-field and Vogel conflict tests in rodents
Q34252638Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies
Q34305078The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics

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