Neurogenic pain and steroid synthesis in the spinal cord

scientific journal article

Neurogenic pain and steroid synthesis in the spinal cord is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1025441459
P356DOI10.1385/JMN:30:3:341
P698PubMed publication ID16632873

P2093author name stringLaurence Meyer
Simona Saredi
Aurélie Béglé
Cherkaouia Kibaly
Christine Patte-Mensah
Véronique Schaeffer
Ayikoe G. Mensah-Nyagan
Domitille Boudard
P2860cites workStructure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonadsQ24310592
Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditismQ24311401
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductasesQ24558620
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductaseQ24561410
Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placentaQ24628732
Characterization and measurement of dehydroepiandrosterone sulfate in rat brainQ24633919
Behavioral effects of 3 alpha-androstanediol. II: Hypothalamic and preoptic area actions via a GABAergic mechanismQ71710868
Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescenceQ71825169
Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brainQ71914483
Avian neurosteroids. II. Localization of a cytochrome P450scc-like substance in the quail brainQ71914488
Ontogeny of expression of the genes for steroidogenic enzymes P450 side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase, P450 17 alpha-hydroxylase/C17-20 lyase, and P450 aromatase in fetal mouse gonadsQ72019780
Immunocytochemical localization of 5 alpha-reductase in rat brainQ72406228
Immunocytochemical localization and biological activity of 3 beta-hydroxysteroid dehydrogenase in the central nervous system of the frogQ72896473
Progesterone is neuroprotective after acute experimental spinal cord trauma in ratsQ73135789
Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacologyQ77354244
Neurosteroids: recent findingsQ77354280
The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodentsQ77354305
Painful neuropathiesQ77663479
Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in ratQ77850688
The 3beta-hydroxysteroid dehydrogenase gene family of enzymesQ81067750
Activity and localization of 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase in the zebrafish central nervous systemQ43763283
Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolismQ43825681
Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesisQ43906806
Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats.Q43962635
3 Beta-hydroxysteroid dehydrogenase expression in rat spinal cordQ44105490
The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5alpha-reduced metabolitesQ44176727
Evaluation of the analgesic effect of neurosteroids and their possible mechanism of action.Q44261363
Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease.Q44315188
Antinociceptive properties of neurosteroids: a comparison of alphadolone and alphaxalone in potentiation of opioid antinociceptionQ44342636
Gestational and ovarian sex steroid antinociception: synergy between spinal kappa and delta opioid systemsQ44349079
Allopregnanolone serum levels and expression of 5α-reductase and 3α-hydroxysteroid dehydrogenase isoforms in hippocampal and temporal cortex of patients with epilepsyQ44438139
Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brainQ44532423
Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neuronesQ44537626
Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathwaysQ44545150
Effects of progesterone derivatives, dihydroprogesterone and tetrahydroprogesterone, on the subependymal layer of the adult rat.Q44773170
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamineQ24685198
Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skinQ28115488
Neuroactive steroidsQ28181775
Neurosteroids in learning and memory processesQ28198194
Molecular mechanisms of nociceptionQ28216291
Steroid 5 alpha-reductase 2 deficiencyQ28257380
Gene structure of human cytochrome P-450(SCC), cholesterol desmolaseQ28288649
Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humansQ28294603
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesQ28296995
Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450scc oligodeoxyribonucleotide probesQ28301384
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous systemQ28511320
Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cordQ28565627
Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functionsQ28566245
Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cordQ28567095
Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brainQ28569291
Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cordQ28569789
Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomeraseQ28570734
Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitroQ28571154
Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissuesQ28579259
Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellumQ28579731
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neuronsQ28580245
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brainQ28585564
Neuronal plasticity: increasing the gain in painQ29615421
Comparative anatomy of the aldo-keto reductase superfamilyQ30043211
Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injuryQ30453985
Cell death in the superficial dorsal horn in a model of neuropathic painQ33181857
Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociceptionQ33216935
Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenaseQ33327829
Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.Q33537213
Neuropathic pain: aetiology, symptoms, mechanisms, and managementQ33661273
Neurosteroids: biosynthesis and function of these novel neuromodulatorsQ33831306
Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?Q34182720
Neurosteroid modulation of GABAA receptorsQ34275980
Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination.Q34319823
Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks.Q45037289
3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation.Q45137581
Caspase signalling in neuropathic and inflammatory pain in the rat.Q45173036
Testosterone inhibits cAMP-induced de Novo synthesis of Leydig cell cytochrome P-450(17 alpha) by an androgen receptor-mediated mechanismQ45371091
5 alpha-reductase isozymes in the central nervous systemQ47997981
Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3beta-hydroxysteroid dehydrogenase in the rat brainQ48005090
Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancyQ48052268
Localization of 3 beta-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridizationQ48148767
Neurosteroids: cytochrome P-450scc in rat brainQ48208079
Expression and activity of 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4-isomerase in different regions of the avian brain.Q48259630
The induction of pain: an integrative reviewQ48284194
Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat.Q48304993
Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.Q48324130
Prenatal experience and postnatal stress modulate the adult neurosteroid and catecholaminergic stress responsesQ48368895
Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes p450scc, P450c17 and 3beta-HSD in the postnatal rat brainQ48399471
Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal lifeQ48495363
Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in ratsQ48569426
Steroidogenic enzyme gene expression in the human brainQ48612764
Involvement of spinal cord delta opiate receptors in the antinociception of gestation and its hormonal simulationQ48706141
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptorsQ48756725
A new nomenclature for the aldo-keto reductase superfamilyQ48772502
Pregnenolone and its sulfate ester in the rat brainQ48793674
The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamusQ48854070
A study of 5 alpha-reductase in human fetal brainQ48912312
Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitroQ49131090
[5-alpha-reductases: physiology and pathology].Q51012403
Antinociceptive properties of neurosteroids I. Spinally-mediated antinociceptive effects of water-soluble aminosteroids.Q51371644
Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression.Q51394480
Nonneuronal localization for steroid converting enzyme: 3 alpha-hydroxysteroid oxidoreductase in olfactory tubercle of rat brain.Q51752812
Generation and characterization of antipeptide antibodies to rat cytochrome P-450 side-chain cleavage enzymeQ52049481
Expression of cytochrome P450 side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase in the rat central nervous system: a study by polymerase chain reaction and in situ hybridization.Q52206923
P450(17 alpha) and P450SCC gene expression and regulation in the rat placentaQ52232484
Micromethod for the determination of 3-beta-HSD activity in cultured cells.Q55485046
Progesterone receptor expression in the brainstem of the female ratQ58314956
Neurosteroids: Expression of Functional 3β-Hydroxysteroid Dehydrogenase by Rat Sensory Neurons and Schwann CellsQ60683594
A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brainQ60683595
Progesterone synthesis and myelin formation by Schwann cellsQ60683596
Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids in amphibiansQ60731237
Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expressionQ67575189
Adrenal P-450scc modulates activity of P-45011 beta in liposomal and mitochondrial membranes. Implication of P-450scc in zone specificity of aldosterone biosynthesis in bovine adrenalQ67728317
Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. The catalytic site remains refractory in the course of intermediary hydroxyprogesterone processingQ67973855
Ontogenetic development of the 5 alpha-reductase in the rat brain: cerebral cortex, hypothalamus, purified myelin and isolated oligodendrocytesQ68029338
Testosterone 5 alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axonsQ68472642
Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cellsQ69749125
Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymesQ70469417
3 alpha-Hydroxysteroid oxidoreductase in rat brainQ70927270
Immunohistochemical localization and immunoblotting of androgen receptor in spinal neurons of male and female ratsQ71147103
In vivo and in vitro evidence for the biosynthesis of testosterone in the telencephalon of the female frogQ71152220
Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brainQ71377559
In vitro conversion of pregnenolone to progesterone by discrete brain areas of the male ratQ71486476
Molecular biology and genetics of the 3 beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene familyQ34409441
Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenaseQ34543736
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.Q34554719
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissuesQ34588430
Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.Q34798306
Neurosteroids in depression: a reviewQ34990942
Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assemblyQ35117179
Precursors of the neurosteroidsQ35162412
Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.Q35207754
Effects of neuroactive steroids on myelin of peripheral nervous systemQ35207768
Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significanceQ35254149
Actions of progesterone and its 5alpha-reduced metabolites on the major proteins of the myelin of the peripheral nervous system.Q35605020
The 5 alpha-reductase in the brain: molecular aspects and relation to brain functionQ35611588
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicityQ35893729
Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cellsQ35973864
Enzymes of Androgen Formation and Degradation in the Human ProstateQ36587799
Cell-type-specific expression of rat steroid 5 alpha-reductase isozymesQ36588621
Characterization, expression, and immunohistochemical localization of 5 alpha-reductase in human skinQ36742131
Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampusQ36833138
Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brainQ37517966
Localization of 17beta-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frogQ37716241
Microtubule-associated proteinsQ37811584
Intermediate filaments: a review of the basic biology.Q38186976
Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cellsQ38920754
Purification and immunochemical characterization of the two adrenal cortex mitochondrial cytochrome P-450-proteinsQ39626961
Neural cell markers and their applications to neurologyQ40105593
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in cultureQ40925821
The 5alpha-reductase in the central nervous system: expression and modes of controlQ41017464
Testosterone and progesterone metabolism in the central nervous system: cellular localization and mechanism of control of the enzymes involvedQ41119283
Metabolism of steroids in the brain: a new insight into the role of 5alpha-reductase and aromatase in brain differentiation and functionsQ41212680
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylaseQ41544955
Hormonally induced neuronal plasticity in the adult motoneuronsQ41643505
Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human fetal adrenal cellsQ42079001
Electrophoretic and immunochemical characterization of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenases of rat tissuesQ42084168
Synthesis of progesterone in Schwann cells: regulation by sensory neurons.Q43551331
Developmental changes in progesterone biosynthesis and metabolism in the quail brain.Q43568147
The aldo-keto reductase (AKR) superfamily: an updateQ43577660
Effects of progesterone synthesized de novo in the developing Purkinje cell on its dendritic growth and synaptogenesis.Q43697255
Regulation of neurosteroid biosynthesis in the frog diencephalon by GABA and endozepines.Q43727447
Immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the brain of the African lungfish Protopterus annectens.Q43728290
Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humansQ43748332
P433issue1
P921main subjectneuropathic painQ2798704
P304page(s)17–31
P577publication date2006-01-01
P1433published inJournal of Molecular NeuroscienceQ15708870
P1476titleNeurogenic pain and steroid synthesis in the spinal cord
P478volume28

Reverse relations

cites work (P2860)
Q38571198Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?
Q93050900Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage
Q60731228Allopregnanolone and Progesterone in Experimental Neuropathic Pain: Former and New Insights with a Translational Perspective
Q46946361Alteration of synaptic activity-regulating genes underlying functional improvement by long-term exposure to an enriched environment in the adult brain.
Q26865759Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship
Q42808484Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System
Q40791238Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice
Q41465921Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury
Q92187927Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain
Q35930094Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain
Q35049356Neurosteroid 3α-androstanediol efficiently counteracts paclitaxel-induced peripheral neuropathy and painful symptoms
Q58586871Neurosteroids in Pain Management: A New Perspective on an Old Player
Q34895372Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are critical
Q35786247Reward processing by the opioid system in the brain.
Q48234893Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats
Q36426980Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein
Q91687453Spinal Interleukin-1β Inhibits Astrocyte Cytochrome P450c17 Expression Which Controls the Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain
Q35818527Steroid Receptor Isoform Expression in Drosophila Nociceptor Neurons Is Required for Normal Dendritic Arbor and Sensitivity
Q37829636The DABBEC phenotyping system: towards a mechanistic understanding of CP/CPPS.

Search more.