Neurosteroids in Pain Management: A New Perspective on an Old Player

scholarly article by Sonja L Joksimovic et al published 2018 in Frontiers in Pharmacology

Neurosteroids in Pain Management: A New Perspective on an Old Player is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2018.01127
P932PMC publication ID6176051
P698PubMed publication ID30333753

P50authorDouglas F CoveyQ87654929
Vesna Jevtovic-TodorovicQ60642341
P2093author name stringSlobodan M Todorovic
Sonja L Joksimovic
P2860cites workHormonal milieu affects tailflick latency in female rats and may be attenuated by access to sucroseQ67505029
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Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's diseaseQ27334826
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The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbensQ28216689
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Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritisQ28581075
Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's diseaseQ28740634
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Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injuryQ30279033
Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.Q30371210
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5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivoQ30434076
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5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic painQ30437972
Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.Q31076606
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Cellular and functional evidence for a protective action of neurosteroids against vincristine chemotherapy-induced painful neuropathy.Q39709025
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Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.Q40949695
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Membrane progesterone receptors localization in the mouse spinal cord.Q43212806
Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroidsQ43270099
Gestational and ovarian sex steroid antinociception: synergy between spinal kappa and delta opioid systemsQ44349079
Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathwaysQ44545150
Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currentsQ44758240
Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cordQ44791905
Testosterone affects formalin-induced responses differently in male and female ratsQ44890699
Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain.Q45070761
Progesterone reduces the expression of spinal cyclooxygenase-2 and inducible nitric oxide synthase and prevents allodynia in a rat model of central neuropathic pain.Q47821856
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.Q48147623
Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence.Q48172129
The induction of pain: an integrative reviewQ48284194
Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activityQ48357310
Involvement of spinal cord delta opiate receptors in the antinociception of gestation and its hormonal simulationQ48706141
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptorsQ48756725
Diet and estrous cycle influence pain sensitivity in ratsQ50126336
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptorsQ33717685
Neurosteroids: biosynthesis and function of these novel neuromodulatorsQ33831306
Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disordersQ33972726
T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal grayQ34092998
Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiationQ34540101
Descending control of painQ34659433
Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are criticalQ34895372
Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.Q34996330
Gonadal hormones and sex differences in pain reactivityQ35147778
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Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve rootQ35860900
Visceral pain: gender differences in response to experimental and clinical painQ35868765
The role of female gonadal hormones in behavioral sex differences in persistent and chronic pain: clinical versus preclinical studiesQ36197444
Sex hormones, central nervous system and painQ36372686
The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspectsQ36394892
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.Q36562979
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Fast synaptic inhibition in spinal sensory processing and pain controlQ36661675
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in miceQ36768687
Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis.Q36871346
The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries.Q36873573
Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transportersQ36995022
Neuroactive steroids: state of the art and new perspectives.Q37014232
Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation.Q37146861
Neuropathic pain: a maladaptive response of the nervous system to damageQ37401775
Evidence for a key role of steroids in the modulation of pain.Q37541440
Neurosteroids: a new brain function?Q38008829
Neurosteroids as regenerative agents in the brain: therapeutic implicationsQ38084436
Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions.Q38130020
Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors.Q38156547
Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotectionQ38246676
Neuroactive steroids and the peripheral nervous system: An update.Q38396464
An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptorQ38483796
NGF/TrkA Signaling as a Therapeutic Target for PainQ38603107
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectpain managementQ621261
pharmacologyQ128406
P304page(s)1127
P577publication date2018-01-01
P1433published inFrontiers in PharmacologyQ2681208
P1476titleNeurosteroids in Pain Management: A New Perspective on an Old Player
P478volume9

Reverse relations

cites work (P2860)
Q92187927Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain
Q64255589Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision
Q90483148L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors
Q90342576Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives