Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.

scientific article

Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M802325200
P698PubMed publication ID18667433

P2093author name stringMichiru Nishita
Yasuhiro Minami
Masahiro Enomoto
Mayumi Hamasaki
Akira Nomachi
Daisuke Inaba
P2860cites workWnt5a signaling directly affects cell motility and invasion of metastatic melanomaQ24300474
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2Q24306687
Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.Q24539100
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate developmentQ28145765
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathwayQ28184356
Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylationQ28268464
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cellsQ28302003
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor contextQ28510950
JNK phosphorylates paxillin and regulates cell migrationQ28575982
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzetaQ28583531
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complexQ28590249
Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migrationQ30480545
Stress-activated protein kinases are negatively regulated by cell density.Q33889582
Evolutionary conservation of microtubule-capture mechanismsQ34627249
Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humansQ35101560
Coordinating cytoskeletal tracks to polarize cellular movementsQ35927687
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarityQ36119733
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid raftsQ40182543
p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascadesQ40660690
Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2.Q40908999
Actin-binding protein requirement for cortical stability and efficient locomotionQ41643536
A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell divisionQ41688982
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebratesQ42113998
Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing.Q42440701
Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilizationQ42824851
The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase IepsilonQ42825361
Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathwayQ42828494
JNK signaling pathway is required for efficient wound healing in DrosophilaQ43169362
Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.Q43655583
JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discsQ47071204
ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.Q47765558
Cell migration in development and disease.Q52959188
P433issue41
P407language of work or nameEnglishQ1860
P304page(s)27973-27981
P577publication date2008-07-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleReceptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.
P478volume283

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cites work (P2860)
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