WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages

scientific article published on 30 January 2018

WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1100694519
P356DOI10.1038/BJC.2017.451
P932PMC publication ID5846063
P698PubMed publication ID29381686

P2093author name stringWun-Jae Kim
Jeong Hee Hong
Christina Jamieson
Geun Taek Lee
Isaac Yi Kim
Young Suk Kwon
Nara Lee
Seok Joo Kwon
Jongmyung Kim
P2860cites workWnt5a signaling directly affects cell motility and invasion of metastatic melanomaQ24300474
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanomaQ24648937
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signalingQ28250146
WNT signaling in bone homeostasis and disease: from human mutations to treatmentsQ28285090
Low expression of Wnt-5a gene is associated with high-risk neuroblastomaQ28297914
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activitiesQ33589161
Wnt5a suppresses osteoblastic differentiation of human periodontal ligament stem cell-like cells via Ror2/JNK signalingQ48168075
Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survivalQ74153839
The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activityQ77678719
Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasionQ79322850
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissueQ79358419
IL-1β mediates MCP-1 induction by Wnt5a in gastric cancer cellsQ33861443
Wnt5a promotes inflammatory responses via nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cellsQ33947233
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathwayQ34493228
RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.Q34494714
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell linesQ34600262
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2Q34706774
Inhibition of angiopoietin-2 in LuCaP 23.1 prostate cancer tumors decreases tumor growth and viabilityQ35014686
Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokinesQ35764436
CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltrationQ35925135
Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiationQ36945973
Wnt5a stimulates chemotactic migration and chemokine production in human neutrophilsQ36982055
A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason ScoreQ37213040
Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseasesQ37520844
Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters.Q37618229
Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 inductionQ37650625
CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasisQ37652169
A novel non-canonical Wnt signature for prostate cancer aggressivenessQ37706021
The dynamic roles of TGF-β in cancerQ37801347
Castration-resistant prostate cancer: adaptive responses in the androgen axisQ38153927
WNT5A has anti-prostate cancer effects in vitro and reduces tumor growth in the skeleton in vivoQ38956252
Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway.Q38981044
GEC-derived SFRP5 inhibits Wnt5a-induced macrophage chemotaxis and activationQ39035083
Cancer Statistics, 2017.Q39038674
Bone morphogenetic protein-6 induces castration resistance in prostate cancer cells through tumor infiltrating macrophagesQ39147073
ROR-Family Receptor Tyrosine KinasesQ39150536
BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophagesQ39157997
Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinaseQ39747925
Interleukin-6 regulates androgen synthesis in prostate cancer cellsQ39819739
WNT5A expression increases during melanoma progression and correlates with outcomeQ39939612
Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosisQ40361017
WNT5A expression in human breast cancer.Q40427508
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.Q41484013
Depletion and reconstitution of macrophages in miceQ42412616
WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine productionQ42498835
Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.Q42810068
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude miceQ42819394
Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathwayQ42828494
PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-nicheQ42938836
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P577publication date2018-01-30
P1433published inBritish Journal of CancerQ326309
P1476titleWNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages

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cites work (P2860)
Q90062344An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma
Q92603261Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis
Q100428112Blood-based gene expression signature associated with metastatic castrate-resistant prostate cancer patient response to abiraterone plus prednisone or enzalutamide
Q91898018Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration
Q91705838Key Genes And Pathways Controlled By E2F1 In Human Castration-Resistant Prostate Cancer Cells
Q64103418M2 macrophages confer resistance to 5-fluorouracil in colorectal cancer through the activation of CCL22/PI3K/AKT signaling
Q92761050Phospholipase C (PLC)ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line
Q99709001SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer
Q91949847The pathological role of Wnt5a in psoriasis and psoriatic arthritis
Q90092788Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression

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