A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia

scientific article published on October 2007

A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF03006927
P8608Fatcat IDrelease_f5a53qdzobab5lu33tyvlkllh4
P698PubMed publication ID17988990

P2093author name stringMasami Bessho
Itsuro Jinnai
Fumiharu Yagasaki
Maho Ishikawa
Tomoya Maeda
Daisuke Okamura
Yuichi Sugahara
P2860cites workA physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathwayQ21735927
A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96Q22009078
Consensus-derived structural determinants of the ankyrin repeat motifQ24541480
Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexesQ24550796
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicityQ24554535
FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression patternQ24561476
The ankyrin repeat as molecular architecture for protein recognitionQ24646394
The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98Q27639518
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)Q28145231
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphomaQ28250347
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusionQ28273363
Molecular mechanisms of myelodysplastic syndromeQ34206550
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.Q34372334
NUP98 gene fusions in hematologic malignancies.Q34420221
Nucleolar adaptation in human cancerQ34452742
NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique.Q36391820
Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported iQ43819283
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) alleleQ43878478
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.Q52543603
A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assayQ56263809
Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemiaQ61852050
Deletion of chromosome arm 3p in hematologic malignanciesQ73605971
Detailed deletion mapping of chromosome arm 3p in breast cancers: a 2-cM region on 3p14.3-21.1 and a 5-cM region on 3p24.3-25.1 commonly deleted in tumorsQ73870264
Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemiaQ78294890
Cryptic insertion producing two NUP98/NSD1 chimeric transcripts in adult refractory anemia with an excess of blastsQ80594737
P433issue3
P921main subjectleukemiaQ29496
P304page(s)238-245
P577publication date2007-10-01
P1433published inInternational Journal of HematologyQ6051416
P1476titleA novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia
P478volume86

Reverse relations

cites work (P2860)
Q34538733A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature
Q35604234Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability
Q43410945Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia.
Q40962969Epstein-Barr virus-positive diffuse large B-cell lymphoma following acute myeloid leukemia: a common clonal origin indicated by chromosomal translocation t(3;4)(p25;q21).
Q84562440Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
Q35608150NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
Q37252910Nuclear pore proteins and cancer
Q30157247Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction
Q34632599Role of the nuclear envelope in genome organization and gene expression