Cryptic insertion producing two NUP98/NSD1 chimeric transcripts in adult refractory anemia with an excess of blasts (scientific article published on 01 December 2004)

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

Q24322575

NSD1 mutations are the major cause of Sotos syndrome and occur in some cases of Weaver syndrome but are rare in other overgrowth phenotypes

Q24615626

Haploinsufficiency of NSD1 causes Sotos syndrome

Q34118696

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).

Q34126338

NUP98 gene fusions in hematologic malignancies.

Q34420221

Molecular characterization of NSD1, a human homologue of the mouse Nsd1 gene

Q34519760

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

Q52543603

A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay

Q56263809

Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia

Q61852050

Successful use of the same slide for consecutive fluorescence in situ hybridization experiments

Q71694548

Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemia

Q78294890

P433

issue

P921

main subject

refractory anemia

Q54971935

P304

page(s)

395-399

P577

publication date

2004-12-01

P1433

published in

Genes, Chromosomes and Cancer

Q5532697

P1476

title

Cryptic insertion producing two NUP98/NSD1 chimeric transcripts in adult refractory anemia with an excess of blasts

P478

volume

Reverse relations

cites work (P2860)

Q42820817	A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia
Q54653249	Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia.
Q35975179	Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype
Q36421138	Histone demethylases and cancer
Q37961859	Histone methylation in myelodysplastic syndromes
Q36391820	NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique.
Q44123939	NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia
Q46277256	NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
Q39134084	The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer
Q37672319	Understanding the language of Lys36 methylation at histone H3.
Q39268171	Writing, erasing and reading histone lysine methylations.