NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia

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NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GCC.22064
P698PubMed publication ID23630019

P2093author name stringAkira Shimada
Hitoshi Ichikawa
Keizo Horibe
Tohru Kobayashi
Masahiro Tsuchida
Hirokazu Arakawa
Yasuhide Hayashi
Ryoji Hanada
Souichi Adachi
Akio Tawa
Manabu Sotomatsu
Myoung-Ja Park
Norio Shiba
Tomohiko Taki
Ichiro Tsukimoto
Aoi Jo
Sachiyo Mitani
P2860cites workCluster analysis and display of genome-wide expression patternsQ24644463
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification studyQ24651897
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutationsQ27824843
The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9Q28214336
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemiaQ28273406
Biology, risk stratification, and therapy of pediatric acute leukemias: an updateQ34764504
Prdm16 is a physiologic regulator of hematopoietic stem cells.Q35029415
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsQ35608150
The pathophysiology of HOX genes and their role in cancer.Q36005947
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemiaQ36174146
NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteinsQ36232552
Genetics of myeloid malignancies: pathogenetic and clinical implicationsQ36254578
NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique.Q36391820
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemiaQ37172988
Acquired copy number alterations in adult acute myeloid leukemia genomesQ37276767
Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implicationsQ37827283
Prospective study of a pirarubicin, intermediate-dose cytarabine, and etoposide regimen in children with Down syndrome and acute myeloid leukemia: the Japanese Childhood AML Cooperative Study GroupQ40148405
Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: the AML99 trial from the Japanese Childhood AML Cooperative Study GroupQ44158544
KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study GroupQ46807536
Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients.Q51655820
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.Q52543603
RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group.Q53384430
DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia.Q53403193
Age-associated difference in gene expression of paediatric acute myelomonocytic lineage leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosis.Q54500618
A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assayQ56263809
Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemiaQ61852050
Cryptic t(5;11)(q35;p15.5) in adult de novo acute myelocytic leukemia with normal karyotypeQ73847829
Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemiaQ78294890
Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemiaQ80310198
Cryptic insertion producing two NUP98/NSD1 chimeric transcripts in adult refractory anemia with an excess of blastsQ80594737
Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: a study of the Japanese childhood AML Cooperative Study GroupQ80974291
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression patternQ84668776
Prospective study of a therapeutic regimen with all‐trans retinoic acid and anthracyclines in combination of cytarabine in children with acute promyelocytic leukaemia: the Japanese childhood acute myeloid leukaemia cooperative studyQ84797439
High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genesQ85068917
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)683-693
P577publication date2013-04-30
P1433published inGenes, Chromosomes and CancerQ5532697
P1476titleNUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia
P478volume52

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cites work (P2860)
Q52641184Acute myeloid leukemia with translocation (1;21).
Q64067556Analysis of genes encoding epigenetic regulators in myeloproliferative neoplasms: Coexistence of a novel mutation in a patient with a p.V617F positive myelofibrosis
Q90010398Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing
Q99637246Covalent inhibition of NSD1 histone methyltransferase
Q90647565Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia
Q26769943Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy
Q38299701EVI1 promotes tumor growth via transcriptional repression of MS4A3.
Q38975075Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair
Q38301831High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML.
Q26775027Histone methyltransferases: novel targets for tumor and developmental defects
Q52885541Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations.
Q92652729Moving Myeloid Leukemia Drug Discovery Into the Third Dimension
Q48164997NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma
Q34318490NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report
Q48250287Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study.
Q39134084The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer