Biology, risk stratification, and therapy of pediatric acute leukemias: an update

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Biology, risk stratification, and therapy of pediatric acute leukemias: an update is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1200/JCO.2010.30.7405
P932PMC publication ID3071256
P698PubMed publication ID21220611
P5875ResearchGate publication ID49742203

P50authorChing-Hon PuiQ66385450
P2093author name stringSoheil Meshinchi
Robert J Arceci
William L Carroll
P2860cites workPrevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology GroupQ24602856
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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factorQ27851558
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Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemiaQ28255265
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Germline genomic variants associated with childhood acute lymphoblastic leukemiaQ28924384
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemiaQ28943308
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaQ29614324
Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000).Q33645760
Treatment strategy and long-term results in pediatric patients treated in two consecutive AML-GATLA trialsQ43753558
Experience with gemtuzumab ozogamycin ("mylotarg") and all-trans retinoic acid in untreated acute promyelocytic leukemiaQ43993658
Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: the AML99 trial from the Japanese Childhood AML Cooperative Study GroupQ44158544
Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemiaQ44265478
Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st centuryQ44586145
Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimenQ44748439
Outcome of childhood acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy.Q44844886
Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22).Q46497558
Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology GroupQ46502896
Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: the Austrian and German acute lymphoblastic leukemiQ46530395
Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Español de Tratamiento en Hematología pediatric-based protocol ALL-96.Q46656690
Results of 58872 and 58921 trials in acute myeloblastic leukemia and relative value of chemotherapy vs allogeneic bone marrow transplantation in first complete remission: the EORTC Children Leukemia Group reportQ46681659
Treatment with all-trans retinoic acid and anthracycline monochemotherapy for children with acute promyelocytic leukemia: a multicenter study by the PETHEMA GroupQ46761558
Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trialsQ46817257
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samplesQ46932369
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidQ47596252
Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimenQ47812693
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic featuresQ47834838
Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.Q51975366
Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: long-term outcome of the children with AML treated on two consecutive trials of Tokyo Children's Cancer Study Group.Q52013638
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia.Q33645862
Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001Q33647139
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.Q33680292
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemiaQ33733461
Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.Q33754603
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B studyQ33897586
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.Q33931890
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemiaQ33985127
Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group ReportQ34003323
Chromosome translocations and covert leukemic clones are generated during normal fetal developmentQ34032151
Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.Q34052581
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.Q34080807
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.Q34156717
Leukaemogenesis: more than mutant genesQ34275371
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.Q34433577
Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B StudyQ34570206
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNetQ34597535
Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children's oncology groupQ34645985
Improved prognosis for older adolescents with acute lymphoblastic leukemia.Q34679298
Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology groupQ34992080
Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial.Q35209900
Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemiaQ35616085
Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cellsQ35847820
Clinical implications of FLT3 mutations in pediatric AML.Q35848876
Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group studyQ35848913
KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemiaQ35850044
GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemiaQ35897407
The incidence and clinical significance of nucleophosmin mutations in childhood AML.Q35901721
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemiaQ35925016
Acute myeloid leukemia and Down syndrome evolution of modern therapy--state of the art reviewQ35944180
The molecular basis of leukemiaQ35961770
Treatment and prevention of tumor lysis syndrome in children. Experience of Associazione Italiana Ematologia Oncologia PediatricaQ35986905
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Q36141686
Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia.Q52906615
Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000.Q52906689
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.Q52933515
A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.Q53232081
Acute Megakaryoblastic Leukaemia: A National Clinical and Biological Study of 53 Adult and Childhood Cases by the Groupe Français d'Hématologie Cellulaire (GFHC)Q53380738
Acute lymphoblastic leukaemiaQ56722375
Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating CellsQ57615422
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of IkarosQ57734316
Novel regions of acquired uniparental disomy discovered in acute myeloid leukemiaQ58054015
Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemiaQ58054017
Is Cytarabine Useful in the Treatment of Acute Promyelocytic Leukemia? Results of a Randomized Trial From the European Acute Promyelocytic Leukemia GroupQ58416054
Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trialsQ58481870
Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trialsQ73063060
Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study groupQ73359118
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal regionQ74267648
Improved outcome after relapse in children with acute myeloid leukaemiaQ79719909
Role of allogeneic stem cell transplantation in FLT3/ITD-positive AMLQ79766644
Acute lymphoblastic leukemiaQ79891876
Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the NetherlandsQ80860639
Acute myelogenous leukemia in Chile PINDA protocols 87 and 92 resultsQ81521487
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study groupQ81585511
Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98Q82269132
Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech RepublicQ82269138
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AMLQ82668142
Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemiaQ83244976
Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocolQ84027433
Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000.Q36246359
Treatment of acute lymphoblastic leukemiaQ36366185
Outcomes in CCG-2961, a children's oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children's oncology groupQ36407162
Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup trial INT0129Q36430103
Treatment of acute promyelocytic leukemia with gemtuzumab ozogamicin.Q36430455
The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute myeloid leukemia in children: an evidence-based reviewQ36707825
New therapeutic strategies for the treatment of acute lymphoblastic leukaemiaQ36724661
What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studiesQ36843677
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemiaQ36969782
A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospectsQ37041909
Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: a report from the Children's Oncology Group Study POG 9421.Q37059586
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemiaQ37172988
JAK mutations in high-risk childhood acute lymphoblastic leukemiaQ37224111
Therapeutic targeting of MLL.Q37234595
The expanding role of arsenic in acute promyelocytic leukemiaQ37257316
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemiaQ37268926
Acquired copy number alterations in adult acute myeloid leukemia genomesQ37276767
Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemiaQ37276772
The leukemic stem cell niche: current concepts and therapeutic opportunitiesQ37295129
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.Q37351577
New genetic abnormalities and treatment response in acute lymphoblastic leukemiaQ37355964
Treatment of childhood acute lymphoblastic leukemiaQ37355973
Clinical implications of molecular genetic aberrations in acute myeloid leukemiaQ37363129
Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group studyQ37412290
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemiaQ37440638
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effectsQ37474395
Enhancing survival outcomes in the management of patients with higher-risk myelodysplastic syndromesQ37654657
Backtracking of leukemic clones to birthQ38422434
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study GroupQ39766394
Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic optionsQ39783711
Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97.Q39918490
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.Q39928804
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocationQ39990704
The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factorsQ40231262
Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent mannerQ40270156
KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survivalQ40357255
Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trialsQ40370520
Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891.Q40392434
Treatment of childhood acute myeloblastic leukemia: dose intensification improves outcome and maintenance therapy is of no benefit--multicenter studies of the French LAME (Leucémie Aiguë Myéloblastique Enfant) Cooperative GroupQ40394531
ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidenceQ41922803
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.Q43185220
Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trialQ43206160
Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999.Q43208675
Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemiaQ43217991
Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004.Q43217994
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemiaQ43221788
Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004).Q43277746
Autologous and allogeneic stem-cell transplantation as salvage treatment of acute promyelocytic leukemia initially treated with all-trans-retinoic acid: a retrospective analysis of the European acute promyelocytic leukemia groupQ43701098
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)551-565
P577publication date2011-01-10
P1433published inJournal of Clinical OncologyQ400292
P1476titleBiology, risk stratification, and therapy of pediatric acute leukemias: an update
P478volume29

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Q33586588Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia
Q34500075Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study
Q91249010Global efforts toward the cure of childhood acute lymphoblastic leukaemia
Q49324130HPRT1 activity loss is associated with resistance to thiopurine in ALL.
Q34866042Health status utilities in pediatrics: a systematic review of acute lymphoblastic leukemia
Q36714994Health-related quality of life and utility scores in short-term survivors of pediatric acute lymphoblastic leukemia
Q48314617Hematopoietic stem cell transplantation in pediatric patients with acute myeloid leukemia without favorable cytogenetics.
Q41036515High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial
Q38301831High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML.
Q33667247High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcome
Q34645259High-risk pediatric acute lymphoblastic leukemia: to transplant or not to transplant?
Q36178314High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.
Q44035793Hmga1 is differentially expressed and mediates silencing of the CD4/CD8 loci in T cell lineages and leukemic cells.
Q64117729Homozygous mutation in NUDT15 in childhood acute lymphoblastic leukemia with increased susceptibility to mercaptopurine toxicity: A case report
Q37650740Host genetic variants of ABCB1 and IL15 influence treatment outcome in paediatric acute lymphoblastic leukaemia
Q26992280How I treat pediatric acute myeloid leukemia
Q45594506How disease advocacy organizations participate in clinical research: a survey of genetic organizations
Q24568045How do we prepare ourselves for a new paradigm of medicine to advance the treatment of pediatric acute lymphoblastic leukemia?
Q35180032Human leukocyte antigen-DRB1 polymorphism in childhood acute lymphoblastic leukemia
Q33729914Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1.
Q39070526Hypoxia-related gene expression profile in childhood acute lymphoblastic leukemia: prognostic implications
Q96616528Ibrutinib is not an effective drug in primografts of TCF3-PBX1
Q38963879Identification of mutant alleles of JAK3 in pediatric patients with acute lymphoblastic leukemia
Q41903687Identifying new targets in leukemogenesis using computational approaches
Q58861726Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols
Q36442504Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial
Q38622686Improved outcome of childhood acute myeloid leukemia in an Eastern European country: Lithuanian experience
Q34679298Improved prognosis for older adolescents with acute lymphoblastic leukemia.
Q36134458Improvement of the Outcome of Relapsed or Refractory Acute Lymphoblastic Leukemia in Children Using a Risk-Based Treatment Strategy.
Q39166310Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.
Q91749435Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil
Q37226741Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
Q36811650Infections during induction therapy of protocol CCLG-2008 in childhood acute lymphoblastic leukemia: a single-center experience with 256 cases in China
Q38720972Inferring a role for methylation of intergenic DNA in the regulation of genes aberrantly expressed in precursor B-cell acute lymphoblastic leukemia
Q34459885Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia
Q35784497Inherited genetic variation in childhood acute lymphoblastic leukemia
Q39141522Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells
Q49787961Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia
Q45351191Initial frequency of CD34+/CD38 - cells is not correlated with minimal residual disease level in 73 Chinese children with B-cell precursor acute lymphoblastic leukemia
Q38984055Inotuzumab ozogamicin in relapsed B-cell acute lymphoblastic leukemia.
Q40295439Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study
Q92417685Insights into the prenatal origin of childhood acute lymphoblastic leukemia
Q41473465Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia
Q42149280Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia.
Q36592140Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth
Q41872478Interference with pre-B-cell receptor signaling offers a therapeutic option for TCF3-rearranged childhood acute lymphoblastic leukemia
Q53085076Interrupted development of dentition in children receiving bone marrow transplantation for acute lymphocytic Leukemia: a case series.
Q36679531Intracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular Targets
Q36751715Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.
Q92903106Is Acute Myeloblastic Leukemia in Children Under 2 Years of Age a Specific Entity? A Report from the FRENCH ELAM02 Study Group
Q37379199L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo.
Q42369939Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia
Q50978065Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia.
Q64120379Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia
Q34221792Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome
Q47144324Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia
Q55664929Low spontaneous apoptosis index at diagnosis predicts a high-risk phenotype in paediatric acute lymphoblastic leukaemia.
Q57815598Low-dose hypomethylating agent decitabine in combination with aclacinomycin and cytarabine achieves a better outcome than standard FLAG chemotherapy in refractory/relapsed acute myeloid leukemia patients with poor-risk cytogenetics and mutations
Q41978213MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Q37676956MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation
Q28658170MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism
Q33762835Management of adult and paediatric acute lymphoblastic leukaemia in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013.
Q38041467Management of small HER2 overexpressing tumours
Q38079075Managing hypersensitivity to asparaginase in pediatrics, adolescents, and young adults
Q36425440Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
Q89865097Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
Q55033075Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.
Q46802244MicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia
Q36413478MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model.
Q50959012Minimal residual disease of leukemia and the quality of cryopreserved human ovarian tissue in vitro.
Q38161393Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
Q51711055Molecular characterization of KMT2A fusion partner genes in 13 cases of pediatric leukemia with complex or cryptic karyotypes.
Q37643136Molecular therapeutic approaches for pediatric acute myeloid leukemia
Q36339717Monoclonal antibody-based therapies: a new dawn in the treatment of acute lymphoblastic leukemia
Q39127003Mouse models of MLL leukemia: recapitulating the human disease
Q48178689Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia
Q50614792Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.
Q37592751NF-kappa B mediated up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia
Q36892602NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia
Q50115786NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.
Q52906780NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.
Q28115755NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
Q44123939NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia
Q56960711NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: a report from the AIEOP-AML group
Q55057111NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.
Q36873283Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia
Q36347988Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.
Q31167575Network Biomarkers Constructed from Gene Expression and Protein-Protein Interaction Data for Accurate Prediction of Leukemia
Q35192790Novel agents for the treatment of childhood acute leukemia
Q38500371Novel approaches to pediatric leukemia treatment
Q38094099Novel therapeutic strategies in adult acute lymphoblastic leukemia--a focus on emerging monoclonal antibodies
Q38096798Novel therapies for children with acute myeloid leukaemia.
Q90355689Omics-based insights into therapy failure of pediatric B-lineage acute lymphoblastic leukemia
Q55064299Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
Q40314122Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
Q47779465Osteonecrosis of the Shoulders in Pediatric Patients Treated for Leukemia or Lymphoma: Single-Institutional Experience
Q45236803Outcome of children treated for relapsed acute lymphoblastic leukemia in Central America.
Q40681571Outcome of children with acute myeloid leukaemia (AML) experiencing primary induction failure in the AIEOP AML 2002/01 clinical trial
Q54310310Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the aieop AML-2002/01 study.
Q41021920Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia
Q38196743Overview of therapy and strategies for optimizing outcomes in de novo pediatric acute myeloid leukemia
Q36317718PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity
Q37121686PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy
Q57292246PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice
Q33798890Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse
Q36163029Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
Q35074246Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor
Q39425967Pediatric haematopoiesis and related malignancies
Q28391712Perspectives on the causes of childhood leukemia
Q36600202Pharmacokinetic Properties of Anticancer Agents for the Treatment of Central Nervous System Tumors: Update of the Literature
Q38186752Pharmacokinetic evaluation of vincristine for the treatment of lymphoid malignancies
Q34221738Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.
Q36161733Phase I/II trial of clofarabine and cytarabine in children with relapsed/refractory acute lymphoblastic leukemia (AAML0523): a report from the Children's Oncology Group
Q49261196Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance
Q41178645Polymorphic variants of GSTM1, GSTT1, and GSTP1 genes in childhood acute leukemias: A preliminary study in Argentina
Q33914131Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia
Q28245060Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia
Q60170367Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia
Q56890609Preliminary investigation on the abnormal mechanism of CD4FOXP3CD25 regulatory T cells in pediatric B-cell acute lymphoblastic leukemia
Q48154097Prevalence and risk factors of cataract after chemotherapy with or without central nervous system irradiation for childhood acute lymphoblastic leukaemia: an LEA study
Q41869513Prevalence of gene rearrangements in Mexican children with acute lymphoblastic leukemia: a population study-report from the Mexican Interinstitutional Group for the identification of the causes of childhood leukemia
Q92481927Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia
Q48231999Prognostic factors in canine acute leukaemias: a retrospective study.
Q35596960Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia
Q27851831Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia
Q34580110Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition
Q37815272Recent research advances in childhood acute lymphoblastic leukemia
Q39822035Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study
Q36709009Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia
Q40273592Recurrent translocation t(10;17)(p15;q21) in minimally differentiated acute myeloid leukemia results in ZMYND11/MBTD1 fusion
Q26864460Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
Q38818016Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.
Q38377577Relapsed acute lymphoblastic leukemia with unusual multiple bone invasions: A case report
Q41560893Relationships of Human Leukocyte Antigen-A, -B, -DRB1 Alleles, and Haplotypes in 129 Ethnic Turkish Patients With Acute Myeloblastic Leukemia
Q52888397Residual disease detected by multidimensional flow cytometry shows prognostic significance in childhood acute myeloid leukemia with intermediate cytogenetics and negative FLT3-ITD: a report from the Tokyo Children's Cancer Study Group.
Q36194222Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group.
Q38264774Risk factors for relapse in childhood acute lymphoblastic leukemia: prediction and prevention
Q98779175Role of microRNA dysregulation in childhood acute leukemias: Diagnostics, monitoring and therapeutics: A comprehensive review
Q38644266Safety and efficacy of nelarabine in children and young adults with relapsed or refractory T-lineage acute lymphoblastic leukaemia or T-lineage lymphoblastic lymphoma: results of a phase 4 study
Q36580010Scaling up cancer care for children without medical insurance in developing countries: The case of Mexico.
Q26864522Second malignant neoplasms and cardiovascular disease following radiotherapy
Q36155399Self-Contained Statistical Analysis of Gene Sets
Q37131922Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group
Q48228311Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia
Q36924713Socioeconomic variation in survival from childhood leukaemia in northern England, 1968-2010.
Q36262391Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion
Q92525673Study protocol for a phase II, multicentre, prospective, non-randomised clinical trial to assess the safety and efficacy of infusing allogeneic activated and expanded natural killer cells as consolidation therapy for paediatric acute myeloblastic le
Q40874665Survival From Childhood Hematological Malignancies in Denmark: Is Survival Related to Family Characteristics?
Q92438795Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant
Q48123405Survivors of childhood and adolescent cancer: life-long risks and responsibilities
Q36967138Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood
Q40485655T-cell acute lymphoblastic leukemia in infants has distinct genetic and epigenetic features compared to childhood cases
Q47564553TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children
Q38371672Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial.
Q91711797Targeted Therapies for Pediatric AML: Gaps and Perspective
Q36989223Targeted drug discovery for pediatric leukemia
Q38214772Targeted nanoparticles for pediatric leukemia therapy
Q52375473Targeting Leukemia Stem Cells in the Bone Marrow Niche.
Q47580446Targeting acute myeloid leukemia by drug-induced c-MYB degradation
Q104073619Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia
Q35334436Targeting cell cycle regulators in hematologic malignancies.
Q35176311Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model
Q35182716Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia
Q38017727Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies
Q92356480The AAA+ATPase RUVBL2 is essential for the oncogenic function of c-MYB in acute myeloid leukemia
Q53116139The Childhood Leukemia International Consortium.
Q90704717The Top 100 Highly Cited Original Articles on Immunotherapy for Childhood Leukemia
Q36745332The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse postinduction therapy in preclinical models of pediatric acute lymphoblastic leukemia.
Q64964729The case of undiagnosed immunodeficiency in child from mother with leukemia anamnesis.
Q95656564The impact of childhood cancer on parental separation, divorce, and family planning in Denmark
Q61445248The journey to CAR T cell therapy: the pediatric and young adult experience with relapsed or refractory B-ALL
Q89960668The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias
Q34516051The molecular mechanics of mixed lineage leukemia
Q35023231The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing
Q41099096The outcomes and treatment burden of childhood acute myeloid leukaemia in Australia, 1997-2008: A report from the Australian Paediatric Cancer Registry.
Q34380874The preparation of HL-60 cells vaccine expressing BCG heat shock protein 70 and detection of its immunogenicity in vitro
Q38833230The role of bortezomib in the treatment of acute lymphoblastic leukemia
Q38083796The role of chromatin remodeling in medulloblastoma.
Q41090525Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia
Q58492911Translokationen des MLL-Gens
Q37233236Transplant-related mortality following allogeneic hematopoeitic stem cell transplantation for pediatric acute lymphoblastic leukemia: 25-year retrospective review
Q48039932Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL-2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation
Q52626221Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group (TCCSG) Study L04-16.
Q42090608Upregulation of miR-142-3p Improves Drug Sensitivity of Acute Myelogenous Leukemia through Reducing P-Glycoprotein and Repressing Autophagy by Targeting HMGB1
Q28390558Use of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemia
Q30979834Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data.
Q37060647What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?
Q92354263Whole transcriptome sequencing reveals a KMT2A-USP2 fusion in infant acute myeloid leukemia
Q52814633Wogonoside exerts growth-suppressive effects against T acute lymphoblastic leukemia through the STAT3 pathway.
Q91861733[Bortezomib and obatoclax for dual blockade of protein degradation pathways show synergistic anti-tumor effect in human acute T lymphoblastic leukemia cells]
Q53742253[Genetic basis of leukemia: Serious consequences of chromosomal translocations].
Q86478970[NT5C2 expression in children with acute leukemia and its clinical significance]
Q94589377[Prognostic significance and risk factors of minimal residual disease ≥1% on 19th day of induction chemotherapy in children with acute lymphoblastic leukemia]
Q53064467[The prognostic significance of proportion of blasts in bone marrow on day 14 during induction chemotherapy in patients with adult Ph-negative acute lymphoblastic leukemia].
Q90245131[Value of S100A8 in evaluating the prognosis of children with acute lymphoblastic leukemia]
Q33872395miR-155 expression and correlation with clinical outcome in pediatric AML: A report from Children's Oncology Group
Q36546505t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature

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