Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations ofIKZF1

scientific article published on 26 February 2015

Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations ofIKZF1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GCC.22245
P698PubMed publication ID25727050

P50authorKajsa PaulssonQ43156682
P2093author name stringBertil Johansson
Mikael Behrendtz
Anders Castor
Linda Olsson
Andrea Biloglav
Ferras Albitar
P2860cites workLong-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemiaQ43221788
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.Q43922213
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factorQ44519043
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.Q45326639
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndromeQ46355702
A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia.Q46677100
Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations.Q46933149
FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patternsQ46944335
Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011.Q50860875
ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia.Q52882383
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.Q53307880
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of IkarosQ57734316
Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocolsQ58861726
A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphomaQ71806450
Location and function of linker histonesQ77659483
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification studyQ24651897
Fast and accurate short read alignment with Burrows-Wheeler transformQ24653853
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP reportQ27851487
IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.Q27851563
Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia.Q27852421
Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitmentQ28202932
The Ikaros gene is required for the development of all lymphoid lineagesQ28594316
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaQ29614324
Control of lymphocyte development by the Ikaros gene familyQ33632444
Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profilesQ33938184
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemiaQ34314927
Biology, risk stratification, and therapy of pediatric acute leukemias: an updateQ34764504
Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.Q35741581
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcomeQ35876592
Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group studyQ35885293
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemiaQ36174146
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET ProjectQ36542815
IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocolQ36862420
Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia.Q36862511
What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?Q37060647
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemiaQ37172988
Genetic loss of SH2B3 in acute lymphoblastic leukemiaQ37215146
JAK mutations in high-risk childhood acute lymphoblastic leukemiaQ37224111
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.Q37226741
IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in TaiwanQ39730823
Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemiaQ39814053
Ikaros isoform x is selectively expressed in myeloid differentiation.Q40665471
Infrequent occurrence of mutations in the PH domain of LNK in patients with JAK2 mutation-negative 'idiopathic' erythrocytosisQ42583762
P433issue5
P921main subjectmutationQ42918
lymphoblastic leukemiaQ18553852
P304page(s)315-325
P577publication date2015-02-26
P1433published inGenes, Chromosomes and CancerQ5532697
P1476titleCooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1
P478volume54

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cites work (P2860)
Q91910029An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia
Q38974705Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
Q35679720Expression of Ik6 and Ik8 Isoforms and Their Association with Relapse and Death in Mexican Children with Acute Lymphoblastic Leukemia
Q41000106Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia
Q91843913IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker?
Q36980511Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
Q41556401Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study.
Q91997647SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain
Q41617996Selected miRNA levels are associated with IKZF1 microdeletions in pediatric acute lymphoblastic leukemia.
Q64965821Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.