Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

scientific article published on 10 August 2010

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2009-08-239681
P932PMC publication ID3321747
P698PubMed publication ID20699438
P5875ResearchGate publication ID45603484

P50authorPaul BowmanQ7149470
Stephen P HungerQ64215088
Mary V RellingQ88331217
Edward J BedrickQ90478028
Huining KangQ90676267
Gregory ReamanQ99568579
Cheryl L. WillmanQ110811050
Michael J BorowitzQ117236346
Bruce M CamittaQ117251690
Carla S WilsonQ117271260
Walker WhartonQ117271261
Charles G. MullighanQ37839132
Deepa BhojwaniQ42324985
Jun J YangQ59146633
Richard C HarveyQ59219178
Malcolm A SmithQ62764622
P2093author name stringMaurice Murphy
Andrew J Carroll
Meenakshi Devidas
Susan R Atlas
Xuefei Wang
James R Downing
William L Carroll
I-Ming Chen
Kevin K Dobbin
Kerem Ar
George S Davidson
P2860cites workAugmented Post-Induction Therapy for Children with High-Risk Acute Lymphoblastic Leukemia and a Slow Response to Initial TherapyQ64225643
Minimal residual disease detection in childhood precursor-B-cell acute lymphoblastic leukemia: relation to other risk factors. A Children's Oncology Group studyQ73720147
Outlier sums for differential gene expression analysisQ83348051
Cluster analysis and display of genome-wide expression patternsQ24644463
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification studyQ24651897
Statistics review 12: survival analysisQ24800418
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Q27824849
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaQ29614324
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemiaQ33591867
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemiaQ33680280
The logrank testQ33685983
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemiaQ33985127
Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG).Q35616078
Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemiaQ35750961
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.Q36098242
Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology GroupQ36478435
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group studyQ36713493
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemiaQ37172988
JAK mutations in high-risk childhood acute lymphoblastic leukemiaQ37224111
Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected]Q37331114
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemiaQ37440638
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study GroupQ39766394
Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia.Q40556012
Racial and ethnic differences in survival of children with acute lymphoblastic leukemiaQ40637235
Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemiaQ40961746
Racial differences in the survival of childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group StudyQ46369449
COPA--cancer outlier profile analysisQ51935849
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemiaQ53307880
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemiasQ53570084
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profilingQ61910882
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
lymphoblastic leukemiaQ18553852
P304page(s)4874-4884
P577publication date2010-08-10
P1433published inBloodQ885070
P1476titleIdentification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
P478volume116

Reverse relations

cites work (P2860)
Q38726016A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration
Q58690864Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia
Q28306608Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target
Q37517874Absence of Genomic Ikaros/IKZF1 Deletions in Pediatric B-Precursor Acute Lymphoblastic Leukemia
Q42226188Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant.
Q58481753Acute lymphoblastic leukaemia
Q91565663Acute lymphoblastic leukaemia
Q58481759Acute lymphoblastic leukemia
Q38502885Adolescent and young adult patients with cancer: a milieu of unique features
Q61449792Advances in biology of acute lymphoblastic leukemia (ALL) and therapeutic implications
Q36752634Advances in the Biology of Acute Lymphoblastic Leukemia—From Genomics to the Clinic
Q38009099Advances in the molecular pathobiology of B-lymphoblastic leukemia
Q35869978An advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia
Q43922213An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.
Q88091540An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression
Q37146303Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL
Q35835290Apoptosis pathway signature for prediction of treatment response and clinical outcome in childhood high risk B-Precursor acute lymphoblastic leukemia
Q38944847Arf proteins in cancer cell migration.
Q83860818Attacking Remaining Challenges in Childhood Leukemia
Q36070046Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development
Q42371687B lymphoblastic leukemia/lymphoma: new insights into genetics, molecular aberrations, subclassification and targeted therapy
Q26798093B-acute lymphoblastic leukemia/lymphoblastic lymphoma
Q38050656B-lineage transcription factors and cooperating gene lesions required for leukemia development
Q90611076BCR/ABL1-like acute lymphoblastic leukemia: How to diagnose and treat?
Q34033206BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
Q34755687Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia
Q36717196Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma
Q34207183Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review
Q38063923Cancer in Australian Aboriginal children: Room for improvement
Q37331221Characterization of leukemias with ETV6-ABL1 fusion
Q33777616Childhood B-acute lymphoblastic leukemia: a genetic update
Q28080463Childhood acute lymphoblastic leukemia: Integrating genomics into therapy
Q33711119Children's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia
Q84948480Clinical and Laboratory Biology of Childhood Acute Lymphoblastic Leukemia
Q92627035Clinical diagnostics and treatment strategies for Philadelphia chromosome-like acute lymphoblastic leukemia
Q36561755Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia
Q36366616Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification
Q47164848Co-occurrence of CRLF2-rearranged and Ph+ acute lymphoblastic leukemia: a report of four patients
Q36106034Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia
Q27853385Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia
Q89777602Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice
Q35053686Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients
Q59529214Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations ofIKZF1
Q64090852Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia
Q48323019Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms
Q39094566DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia.
Q42068556Deciphering "B-others": Novel fusion genes driving B-cell acute lymphoblastic leukemia
Q38757530Defective quorum sensing of acute lymphoblastic leukemic cells: evidence of collective behavior of leukemic populations as semi-autonomous aberrant ecosystems
Q50860875Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011.
Q34273750Depletion of Cytotoxic T-Cells Does Not Protect NUP98-HOXD13 Mice from Myelodysplastic Syndrome but Reveals a Modest Tumor Immunosurveillance Effect
Q37483972Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
Q47109080Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis
Q52686108Detection of recurrent and of novel fusion transcripts in myeloid malignancies by targeted RNA sequencing
Q26824387Diagnosis and subclassification of acute lymphoblastic leukemia
Q39186808Disruption of E627 and R683 interaction is responsible for B-cell acute lymphoblastic leukemia caused by JAK2 R683G(S) mutations
Q33998291Dose intensification of methotrexate and cytarabine during intensified continuation chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: POG 9406: a report from the Children's Oncology Group
Q52882383ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia
Q37594153ETS-related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia
Q38844207ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
Q26770327Emerging technologies in paediatric leukaemia
Q34790870Evaluation of a side population of canine lymphoma cells using Hoechst 33342 dye
Q35079398Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia
Q88104986Expression of Coagulation Factor XIII Subunit A Correlates with Outcome in Childhood Acute Lymphoblastic Leukemia
Q64111281Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation
Q37500159Fine-tuning patient-derived xenograft models for precision medicine approaches in leukemia
Q88160433GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer
Q35802220Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study
Q39180500Genetic Basis of Acute Lymphoblastic Leukemia
Q36174146Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
Q38716760Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.
Q36778481Genetic risk prediction for normal-karyotype acute myeloid leukemia using whole-exome sequencing
Q57175475Genetics and epigenetics of pediatric leukemia in the era of precision medicine
Q37408629Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Q41000106Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia
Q38223490Genomic characterization of acute leukemias
Q37359118Genomic characterization of childhood acute lymphoblastic leukemia
Q91249010Global efforts toward the cure of childhood acute lymphoblastic leukaemia
Q91522449H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells
Q37580303High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement
Q49692632High PDGFRA expression does not serve as an effective therapeutic target in ERG-deleted B-cell precursor acute lymphoblastic leukemia
Q50043074High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia
Q36765731High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia
Q41823245High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia.
Q34645259High-risk pediatric acute lymphoblastic leukemia: to transplant or not to transplant?
Q90466697How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia
Q101226735IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells
Q36862420IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Q41688725IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951.
Q36977450IKZF1 deletion is associated with a poor outcome in pediatric B‐cell precursor acute lymphoblastic leukemia in Japan
Q39730823IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan
Q36980511Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
Q40791978Identification of a novel susceptibility locus at 16q23.1 associated with childhood acute lymphoblastic leukemia in Han Chinese
Q34957024Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.
Q42831329Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philade
Q36058255Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group
Q35688742Improving access to novel agents for childhood leukemia
Q35971733In Search of Targeted Therapies for Childhood Cancer
Q92377690Inclusion of special populations in clinical research: important considerations and guidelines
Q37226741Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
Q39369458Inferior outcomes for black children with high risk acute lymphoblastic leukemia and the impact of socioeconomic variables
Q33688248Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
Q92441849Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome
Q28602517Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors
Q37533656Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Q30842603Integration of cytogenomic data for furthering the characterization of pediatric B-cell acute lymphoblastic leukemia: a multi-institution, multi-platform microarray study
Q33580638Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia
Q26991810Janus kinase deregulation in leukemia and lymphoma
Q58125084Keeping PACE with Ph Positive to Ph-Like Detection in B-Lineage Acute Lymphoblastic Leukemia: A Practical and Cost Effective (PACE) Approach in a Resource Constrained Setting
Q35220417Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
Q28274115LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors
Q36014047Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia
Q35838562Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development
Q43248878LncRNAs downregulated in childhood acute lymphoblastic leukemia modulate apoptosis, cell migration, and DNA damage response
Q36246434Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer
Q35827910Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia
Q41978213MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Q41667201Metabolic gatekeeper function of B-lymphoid transcription factors
Q36688035Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia.
Q47370037Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.
Q36351111NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
Q26749177New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia
Q38724079Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future
Q33551348Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.
Q90458184Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL
Q37883008Optimal therapy for acute lymphoblastic leukemia in adolescents and young adults
Q35885293Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study
Q34172033Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease
Q42376333Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia
Q37917735Pathobiology of acute lymphoblastic leukemia
Q36163029Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
Q39027852Ph-like acute lymphoblastic leukemia
Q39128765Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults
Q54989161Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.
Q43431904Philadelphia chromosome-like acute lymphoblastic leukemia
Q45970621Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.
Q37166872Plasma methotrexate, red blood cell methotrexate, and red blood cell folate values and outcome in children with precursor B-acute lymphoblastic leukemia: a report from the Children's Oncology Group
Q38117685Predicting relapse risk in childhood acute lymphoblastic leukaemia
Q89777332Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways
Q39992854Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes
Q54120651Prognostic significance of copy number alterations detected by multi-link probe amplification of multiple genes in adult acute lymphoblastic leukemia
Q53831155Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols.
Q92382762Prognostic significance of the tumor suppressor protein p53 gene in childhood acute lymphoblastic leukemia
Q37673367Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL.
Q28087446Prognostification of ALL by Cytogenetics
Q34381851Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia
Q36265485RCSD1-ABL1 Translocation Associated with IKZF1 Gene Deletion in B-Cell Acute Lymphoblastic Leukemia
Q36713389RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction
Q91287120Randomized assessment of delayed intensification and two methods for parenteral methotrexate delivery in childhood B-ALL: Children's Oncology Group Studies P9904 and P9905
Q52575378Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications.
Q92508206Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
Q35723998Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia
Q64979087Recurrent Patterns of Protein Expression Signatures in Pediatric Acute Lymphoblastic Leukemia: Recognition and Therapeutic Guidance.
Q26864460Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
Q90074518Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia
Q90638583Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols
Q35106844Remaining challenges in childhood cancer and newer targeted therapeutics
Q38264774Risk factors for relapse in childhood acute lymphoblastic leukemia: prediction and prevention
Q55057300Routine application of a novel MLPA-based first-line screening test uncovers clinically relevant copy number aberrations in haematological malignancies undetectable by conventional cytogenetics.
Q36201677Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia
Q91632856Sequential Infusion of Anti-CD22 and Anti-CD19 Chimeric Antigen Receptor T Cells for a Pediatric Ph-Like B-ALL Patient That Relapsed After CART-Cell and Haplo-HSCT Therapy: A Case Report and Review of Literature
Q38804856Signaling proteins and transcription factors in normal and malignant early B cell development.
Q48681218Simultaneous use of multiplex ligation-dependent probe amplification assay and flow cytometric DNA ploidy analysis in patients with acute leukemia
Q34325528Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL.
Q36323903Specific expression of novel long non-coding RNAs in high-hyperdiploid childhood acute lymphoblastic leukemia
Q41228748Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/-Bcl-xLTg mice
Q54966011Structural basis of DUX4/IGH-driven transactivation.
Q82714412Taking childhood leukemia personally
Q46711660Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group
Q37438996Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia
Q36352535Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
Q89723083Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients
Q36128393The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia
Q34235906The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia
Q34167952The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution
Q95277349The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective
Q37995811The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia
Q57158107The genetic basis and cell of origin of mixed phenotype acute leukaemia
Q48090552The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.
Q41331438The non-coding RNA landscape of human hematopoiesis and leukemia.
Q38508845The role of CCN family genes in haematological malignancies.
Q36475964The role of phenotype in gene discovery in the whole genome sequencing era
Q33700016The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression
Q59810097Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia
Q41090525Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia
Q34182738Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase
Q36571783Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia
Q37967302Tyrosine Kinase Inhibitor Use in Pediatric Philadelphia Chromosome–Positive Acute Lymphoblastic Anemia
Q36542815Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project
Q34820332Unique Characteristics of Adolescent and Young Adult Acute Lymphoblastic Leukemia, Breast Cancer, and Colon Cancer
Q32182056Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J.
Q28390558Use of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemia
Q90029220Using genomics to define pediatric blood cancers and inform practice
Q33705933VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
Q90989897Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting
Q26770729ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies
Q58122394[The expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia and its prognostic significance]
Q35009302miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.

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