Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles

scientific article published on March 1995

Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ3060359
P932PMC publication ID1136529
P698PubMed publication ID7887889
P5875ResearchGate publication ID15311118

P2093author name stringMurphy MP
Ramsay RR
Sablin SO
Krueger MJ
Singer TP
P2860cites workStructural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondriaQ34322151
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicityQ37683630
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compoundsQ40848755
Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenoneQ41231883
Potentiation by the tetraphenylboron anion of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its pyridinium metabolite.Q41741720
Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrodeQ42101200
Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidasesQ42853435
4'-alkylated analogs of 1-methyl-4-phenylpyridinium ion are potent inhibitors of mitochondrial respirationQ43696049
Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.Q46015264
Enhancement by tetraphenylboron of the interaction of the 1-methyl-4-phenylpyridinium ion (MPP+) with mitochondriaQ46051390
Reactivation of NADH dehydrogenase (complex I) inhibited by 1-methyl-4-(4'-alkylphenyl)pyridinium analogues: a clue to the nature of the inhibition siteQ46120445
Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondriaQ48333081
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineQ48477579
Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTPQ48590320
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidaseQ48681443
Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. XV. Interactions of piericidin with the mitochondrial respiratory chain.Q52472816
Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparations.Q52542985
Use of an electrode selective for 1-methyl-4-phenylpyridinium (MPP+) to measure its uptake and accumulation by mitochondria.Q64968534
Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvementQ67724128
Enhancement of the uptake of 1-methyl-4-phenylpyridinium ion (MPP+) in mitochondria by tetraphenylboronQ68068846
Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTPQ68834136
Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+Q69876986
Studies on the characterization of the inhibitory mechanism of 4'-alkylated 1-methyl-4-phenylpyridinium and phenylpyridine analogues in mitochondria and electron transport particlesQ72069869
Studies on the electron transfer system. IV. The electron transfer particleQ74320697
STUDIES ON THE RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE. VI. FURTHER PURIFICATION AND PROPERTIES OF THE ENZYME FROM BEEF HEARTQ76959975
P407language of work or nameEnglishQ1860
P921main subjecthydrophobicityQ41854968
P304page(s)359-365
P577publication date1995-03-01
P1433published inBiochemical JournalQ864221
P1476titleInhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles
P478volume306 ( Pt 2)

Reverse relations

cites work (P2860)
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Q34412601Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death
Q46075747MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood.
Q39400621Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.
Q30653117Numerical methods for handling uncertainty in microarray data: an example analyzing perturbed mitochondrial function in yeast
Q73066768Origin of selective inhibition of mitochondrial complex I by pyridinium-type inhibitor MP-24
Q34429389Probing the ubiquinone reduction site in bovine mitochondrial complex I using a series of synthetic ubiquinones and inhibitors
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Q35119950The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons
Q44807878Vasorelaxation and hyperpolarisation of rat small mesenteric artery by the quaternary anion tetraphenylboron

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