MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function

scientific article published on 10 August 2001

MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M101647200
P698PubMed publication ID11500488

P2093author name stringE B Voura
R Khokha
K L Watson
P D Soloway
A T Ho
P2860cites workConstitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaQ24336272
Growth control in mammalian cells by cell-cell contactsQ24669963
Cell adhesion: the molecular basis of tissue architecture and morphogenesisQ28276573
Contact inhibition of growth of human diploid fibroblasts by immobilized plasma membrane glycoproteinsQ28303806
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysinQ28589898
A causal role for E-cadherin in the transition from adenoma to carcinomaQ29616122
Matrix metalloproteinases: a reviewQ29620220
Proteolysis and cell migration: creating a path?Q33744936
Cadherins and their connections: adhesion junctions have broader functions.Q33744981
Matrix metalloproteinases in tumour invasion and metastasisQ33765792
The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesisQ33783677
Focal adhesions - the cytoskeletal connectionQ33840319
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.Q34442292
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.Q34733220
Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasionQ35186457
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expressionQ36233928
Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cellsQ36255048
In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancyQ36255141
The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrinsQ36328276
Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocanQ36328286
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulationQ36618743
Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinasesQ36882797
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinaseQ38330900
Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesisQ40017401
Analysis of FAK-associated signaling pathways in the regulation of cell cycle progressionQ40836995
Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrestQ40933661
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumorsQ40949632
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interactionQ40957062
Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphologyQ40974936
Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell lineQ41035774
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive propertiesQ41126999
Changing views of the role of matrix metalloproteinases in metastasisQ41592276
Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cellsQ41617910
ECM and cell surface proteolysis: regulating cellular ecologyQ41656253
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor roleQ41674960
Tumor Cell Invasion Inhibited by TIMP-2Q41679983
beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancerQ42794991
Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cellsQ42799828
Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm? [corrected].Q42829537
Collagen synthesis as a marker for cell type in mouse 3T3 linesQ42831489
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cellsQ43107815
Cell-adhesion-dependent influences on genomic instability and carcinogenesis.Q46038956
Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4.Q48048643
P433issue43
P407language of work or nameEnglishQ1860
P304page(s)40215-40224
P577publication date2001-08-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleMMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function
P478volume276

Reverse relations

cites work (P2860)
Q41810809A Nonantibiotic Chemically Modified Tetracycline (CMT-3) Inhibits Intimal Thickening
Q40267315A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration
Q38336975A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of beta-catenin
Q41107179ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
Q37378757Activation of the integrins alpha 5beta 1 and alpha v beta 3 and focal adhesion kinase (FAK) during arteriogenesis
Q36462433Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway
Q38888512C-reactive protein inhibits expression of N-cadherin and ZEB-1 in murine colon adenocarcinoma
Q36324407Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact
Q38623234Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices
Q43004342Effect of doxycycline on proliferation, MMP production, and adhesion in LAM-related cells
Q40646262Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation
Q24604279Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
Q35016861Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation
Q24298311Induction of cell–cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family
Q35914351Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases
Q34602271Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo
Q35791414Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium
Q36974860Matrix Metalloproteinases as Mediators of Primary and Secondary Cataracts
Q40195910Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3.
Q33231118Matrix metalloproteinase inhibitors suppress transforming growth factor-beta-induced subcapsular cataract formation
Q74534874Matrix metalloproteinase-2 is involved in A549 cell migration on laminin-10/11
Q35581768Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development
Q58211740Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration
Q34510788Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium
Q38807097N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1.
Q36846663Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta-induced epithelial to mesenchymal transition of lens epithelial cells
Q35170428Role of tissue stroma in cancer cell invasion
Q28258973Structural basis of interaction between protein tyrosine phosphatase PCP-2 and beta-catenin
Q47597474Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha
Q44120004Synthetic matrix metalloproteinase inhibitor decreases early cardiac neural crest migration in chicken embryos
Q53363489TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms.
Q38785433TIMPs: versatile extracellular regulators in cancer
Q42575229Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice
Q36609712Transcriptional control of cardiac fibroblast plasticity

Search more.