K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

scientific article published on December 2000

K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID11118062

P50authorLourdes FarréQ55271311
Ramón ManguesQ55603191
Isolda CasanovaQ73299593
P2093author name stringMazo A
Guerrero S
Capellà G
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
overexpressionQ61643320
P304page(s)6750-6756
P577publication date2000-12-01
P1433published inCancer ResearchQ326097
P1476titleK-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression
P478volume60

Reverse relations

cites work (P2860)
Q92286756A Review on Dietary Intervention in Obesity Associated Colon Cancer
Q35402251A specific KRAS codon 13 mutation is an independent predictor for colorectal cancer metachronous distant metastases
Q33811768Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency
Q64238513An occult urothelial carcinoma with wide multiorgan metastases and its genetic alteration profiling: Case report and literature review
Q41525845Analysis of K-Ras Interactions by Biotin Ligase Tagging.
Q34259118Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species
Q26828992Are KRAS/BRAF Mutations Potent Prognostic and/or Predictive Biomarkers in Colorectal Cancers?
Q36416491Association Between Specific Mutations in KRAS Codon 12 and Colorectal Liver Metastasis.
Q34607305Association between specific KRAS mutations and the clinicopathological characteristics of colorectal tumors
Q34517338BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients
Q34394189CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis
Q40313679Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor
Q41044367Clinical parameters to guide decision-making in elderly metastatic colorectal CANCER patients treated with intensive cytotoxic and anti-angiogenic therapy.
Q35579056Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages
Q35109213Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines
Q92709364Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
Q34598203Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations
Q26740067Current targeted therapies in the treatment of advanced colorectal cancer: a review
Q38238599Decoding RAS isoform and codon-specific signalling.
Q46148260Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility
Q40346822Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey.
Q37401956Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype
Q35166709Differential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations
Q33635144Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm
Q34149887EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells
Q92089031Emergence of KRAS p.G13D mutation and acquired resistance to cetuximab in colorectal cancer with vulvar metastasis: A case report
Q36557197Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients.
Q34478077Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer
Q64982130Genetic characterisation of molecular targets in carcinoma of unknown primary.
Q90647892Impact of RAS mutation subtype on clinical outcome-a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer
Q43811983Impact of second-line and later cetuximab-containing therapy and KRAS genotypes in patients with metastatic colorectal cancer: a multicenter study in Japan
Q36648105Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
Q54301071Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Q36797103Involvement of KRAS G12A mutation in the IL-2-independent growth of a human T-LGL leukemia cell line, PLT-2
Q92477586Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D
Q49668169KRAS Alleles: The Devil Is in the Detail
Q48097655KRAS Exon 2 Mutations as Prognostic Indicators in Advanced Colorectal Cancer in Clinical Practice: A Mono-Institutional Study
Q34039936KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model
Q92734257KRAS and BRAF Mutations as Prognostic and Predictive Biomarkers for Standard Chemotherapy Response in Metastatic Colorectal Cancer: A Single Institutional Study
Q35045790KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients
Q53304753KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy
Q90216637KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells
Q34157801KRAS and DAXX/ATRX gene mutations are correlated with the clinicopathological features, advanced diseases, and poor prognosis in Chinese patients with pancreatic neuroendocrine tumors
Q33693309KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 alliance).
Q37709323KRAS exon 2 codon 13 mutation is associated with a better prognosis than codon 12 mutation following lung metastasectomy in colorectal cancer
Q36100844KRAS mutant colorectal tumors: past and present
Q39270840KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines
Q24598640Markers of resistance to anti-EGFR therapy in colorectal cancer
Q43182172Meta-analysis of the mutational status of circulation tumor cells and paired primary tumor tissues from colorectal cancer patients
Q42354892MicroRNAs: a new tool in the complex biology of KRAS mutated non-small cell lung cancer?
Q37139174Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention
Q49679318Mutations in KRAS codon 12 predict poor survival in Chinese patients with metastatic colorectal cancer
Q41614877Mutations in Specific Codons of the KRAS Oncogene are Associated with Variable Resistance to Neoadjuvant Chemoradiation Therapy in Patients with Rectal Adenocarcinoma
Q36712670NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Q38114835New targets in non-small cell lung cancer
Q92617679Not all mutations of KRAS predict poor prognosis in patients with colorectal cancer
Q35882193Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression
Q37123400Overexpressed vs mutated Kras in murine fibroblasts: a molecular phenotyping study.
Q26822817Personalized treatment for advanced colorectal cancer: KRAS and beyond
Q91756078Phenotypic characterization of the novel, non-hotspot oncogenic KRAS mutants E31D and E63K
Q39716970Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells.
Q37697540Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer.
Q38582586Prognostic and Predictive Value of RAS Gene Mutations in Colorectal Cancer: Moving Beyond KRAS Exon 2.
Q35775729Prognostic impact of KRAS mutation subtypes in 677 patients with metastatic lung adenocarcinomas
Q33778129Prognostic relevance of KRAS genotype in metastatic colorectal cancer patients unfit for FIr-B/FOx intensive regimen
Q38600228Prognostic value of KRAS codon 13 gene mutation for overall survival in colorectal cancer: Direct and indirect comparison meta-analysis.
Q34470974Prognostic value of KRAS genotype in metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) according to extension of metastatic disease
Q35125613Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours
Q35683647RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally
Q57033842RAS variant signalling
Q40961495Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray.
Q42160986Role of KRAS mutation as predictor of pathologic response after neoadjuvant chemoradiation therapy for rectal cancer
Q37243407Site-dependent differences in clinical, pathohistological, and molecular parameters in metastatic colon cancer
Q39139086Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer
Q36761405Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers
Q37339461Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer
Q34626362The impact of KRAS mutations on VEGF-A production and tumour vascular network
Q35859128The molecular basis of chemoradiosensitivity in rectal cancer:implications for personalized therapies
Q36906563The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma
Q34365654The structural basis for cancer treatment decisions
Q92265928Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD
Q42820759Treating KRAS-mutant NSCLC: latest evidence and clinical consequences
Q37031288Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
Q34622865Worse prognosis of KRAS c.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx)
Q28583902p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells

Search more.